Introduction: The association of reduced mineral density (BMD) and cardiovascular age
(CVD) have been described as a disease, regardless of genetics, and the epidemiological
similarities between arterial wall calcification and osteopathy. Objective: To evaluate the
association between the reduction of BMD and CVR in people living with HIV/AIDS
(PLHIV) associated with the use of Antiretroviral Therapy (ART). Method: This is a cross sectionalanalytical study, with 82 PLHIV individuals, of both sexes, who underwent BMD
using dualenergy Xray absorptiometry imaging of the lumbar spine (LC) and femoral neck
(FC) and counting of CD4+ T cells. The RCV was estimated by the PLHIVspecific reduced
datacollection on adverse effects of antiHIV drugs (D:A:D) algorithm. Data analysis was
performed using EpiInfo (version 7.2.4), Bioestat 5.3 and JAMOVI 1.6.23 software. Results:
A high prevalence of reduced BMD (62.2%), CVR severity (high risk: 26.83%; very high risk
42.68%) and a high prevalence of associated risk factors (age, lipodystrophic syndrome) were
found. , dyslipidemia and diabetes). An association was found between the reduction in BMD
and CVR in both sexes (p=0.0207), pointing out that PLHIV in this study with bone mass loss
were 3.90 times more likely to develop adverse cardiovascular events than those who does not
have normal BMD. A significant negative correlation was also found between the reduction
of the FC Tscore (p=0.0212) and CL (p=0.0159) with the increase in the CVR. Univariate
ordinal logistic regression showed an independent association between osteoporosis and CVR
(p=0.042; OR: 1.30; 95% CI: 1.19–1.44). In the multivariate analysis, only age, sex and
diabetes associated with increased CVR persisted. Conclusions: There is a high prevalence of
reduced BMD, high CVR and common risk factors among them in PLHIV. Lower levels of
BMD are associated with higher CVR in men and women PLHIV and may predict a higher
risk of morbidity in this population.
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