Introduction: the novel coronavirus (SARS-CoV-2), causative agent of COVID-19,
was acknowledged by the World Health Organization as the cause of the pandemic
that started at the beginning of 2020. This infection presents itself in different ways,
varying between asymptomatic and serious, fatal natures, with systemic,
inflammatory and thrombotic occurrences. Researches show that the analysis of
laboratory parameters allows to establish a prognosis, therefore the most appropriate
management of this new human infection. Goals: to describe admitted patients
epidemiological profile and correlate the hepatic biochemical alterations with their
respective clinical developments. Material and methods: A cross-sectional,
descriptive and observational study, performed in a benchmark hospital at the north
of Brazil with mild and serious cases of COVID-19, diagnosed with nasal swab’s RT PCR. The data was obtained by analyzing medical records, selecting patients of both
sexes, over 18 years of age, and whose records allowed the standard protocol to be
completely filled out. This research obtained the consent of the local Human
Research Ethics Committee. Results: In the period under study, from 176
hospitalizations, 96 medical records were selected, being 51 (53%) admitted to the
Intensive Care Unit and 45 (47%) admitted to ward beds. There was a predominance
of the male gender and mean age (58.5 years) in both groups, with greater
precedence being Belém and the metropolitan region (54% against 46%). Regarding
laboratory data, higher levels of AST, ALT, CRP, urea and creatinine were found in
ICU patients, with mechanical ventilation and death rates of 62.4% and 58%,
respectively. Conclusion: the results of this study show that among the hepatic
biochemical tests, there was a correlation of the higher levels of transaminases with
greater severity of the disease and with a more reserved prognosis, being necessary
to expand the casuistic for more definitive conclusions.
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