Creatine is a natural substance found in our body, mainly in the muscles. Its discovery dates
back to the 19th century when the French chemist Michel Eugène Chevreul isolated this
substance from muscle tissue. Once produced, creatine is released into the bloodstream and
transported to tissues throughout the body, including the brain. In the brain, creatine plays an
important role in energy supply. In this regard, the aim of this work is to analyze existing
studies on the effect of creatine supplementation on brain function, seeking to better
understand the potential benefits of this supplementation for the brain. This is a systematic
literature review where a detailed and thorough search was conducted in electronic databases
such as Science Direct, Medical Literature Analysis and Retrieval System Online
(MEDLINE), and the National Library of Medicine (PubMed). Creatine supplementation has
been shown to improve cognitive function in healthy older individuals, with possible
neuroprotective effects in neurological conditions such as Parkinson's disease and autism
spectrum disorder (ASD). Furthermore, creatine supplementation has also shown a positive
impact on mental health, including disorders such as depression. Based on the analysis of
existing studies on the effect of creatine supplementation on brain function, it is concluded
that there is evidence of potential benefits of this supplementation for the brain.
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