Polycystic Ovary Syndrome (PCOS) and Endometriosis are gynecological diseases that affect millions of women of reproductive age, compromising their quality of life due to symptoms such as metabolic alterations, chronic pain and infertility. This study aims to evaluate the efficacy and safety of different pharmacological approaches in the management of Polycystic Ovary Syndrome (PCOS) and Endometriosis. This study is an integrative review based on articles from the last 10 years, collected in the PubMed, Scielo and Google Scholar databases. The search resulted in 68 articles, of which 12 were selected for PCOS, 12 for endometriosis and 2 for surgical intervention. The results, detailed in Tables 1, 2 and 3, highlight the title, authors, objectives and conclusions, focusing on the efficacy, safety and adverse effects of pharmacological approaches, including hormonal treatments and more recent therapies. For PCOS, the main pharmacological approaches are COCs to regulate menstruation and treat hyperandrogenism, combined with insulin sensitizers. For endometriosis, COCs and progestogens are recommended for symptomatic relief, and laparoscopy, in addition to being diagnostic, can treat lesions and prevent recurrences when combined with drugs. The studies analyzed highlight the importance of individualized pharmacological approaches in the management of PCOS and Endometriosis, aiming to alleviate symptoms, improve quality of life and minimize risks, considering the particularities of each patient. Despite the advances, future research is essential to develop more effective therapies and better understand the physical and emotional impacts, promoting holistic and patientcentered pharmacological care.
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