In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants
In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isol...
| Autor principal: | Andrade Neto, Valter Ferreira de |
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| Outros Autores: | Pohlit, Adrian Martin, Pinto, Ana Cristina da Silva, Silva, Ellen Cristina Costa, Nogueira, Karla Lagos, Melo, Márcia R.S., Henrique, Marycleuma Campos, Amorim, Rodrigo C.N., Silva, Luis Francisco Rocha, Costa, Mônica Regina Farias, Nunomura, Rita de Cássia Saraiva, Nunomura, Sergio Massayoshi, Alecrim, Wilson Duarte, Alecrim, Maria das Graças Costa, Chaves, Francisco Célio Maia, Vieira, Pedro Paulo Ribeiro |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Memórias do Instituto Oswaldo Cruz
2020
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https://repositorio.inpa.gov.br/handle/1/14525 |
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oai:repositorio:1-14525 In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants Andrade Neto, Valter Ferreira de Pohlit, Adrian Martin Pinto, Ana Cristina da Silva Silva, Ellen Cristina Costa Nogueira, Karla Lagos Melo, Márcia R.S. Henrique, Marycleuma Campos Amorim, Rodrigo C.N. Silva, Luis Francisco Rocha Costa, Mônica Regina Farias Nunomura, Rita de Cássia Saraiva Nunomura, Sergio Massayoshi Alecrim, Wilson Duarte Alecrim, Maria das Graças Costa Chaves, Francisco Célio Maia Vieira, Pedro Paulo Ribeiro Antimalarial Agent Plant Extract Animals Apocynaceae Brasil Chemistry Drug Effect Drug Sensitivity Isolation And Purification Plasmodium Falciparum Simaroubaceae Animal Antimalarials Apocynaceae Brasil Parasitic Sensitivity Tests Plant Extracts Plasmodium Falciparum Simaroubaceae Apocynaceae Aspidosperma Aspidosperma Desmanthum Lepianthes Peltata Picrolemma Piperaceae Plasmodium Falciparum Simaroubaceae In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived. 2020-04-24T16:49:27Z 2020-04-24T16:49:27Z 2007 Artigo https://repositorio.inpa.gov.br/handle/1/14525 10.1590/S0074-02762007000300016 en Volume 102, Número 3, Pags. 359-365 Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Memórias do Instituto Oswaldo Cruz |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Antimalarial Agent Plant Extract Animals Apocynaceae Brasil Chemistry Drug Effect Drug Sensitivity Isolation And Purification Plasmodium Falciparum Simaroubaceae Animal Antimalarials Apocynaceae Brasil Parasitic Sensitivity Tests Plant Extracts Plasmodium Falciparum Simaroubaceae Apocynaceae Aspidosperma Aspidosperma Desmanthum Lepianthes Peltata Picrolemma Piperaceae Plasmodium Falciparum Simaroubaceae |
| spellingShingle |
Antimalarial Agent Plant Extract Animals Apocynaceae Brasil Chemistry Drug Effect Drug Sensitivity Isolation And Purification Plasmodium Falciparum Simaroubaceae Animal Antimalarials Apocynaceae Brasil Parasitic Sensitivity Tests Plant Extracts Plasmodium Falciparum Simaroubaceae Apocynaceae Aspidosperma Aspidosperma Desmanthum Lepianthes Peltata Picrolemma Piperaceae Plasmodium Falciparum Simaroubaceae Andrade Neto, Valter Ferreira de In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants |
| topic_facet |
Antimalarial Agent Plant Extract Animals Apocynaceae Brasil Chemistry Drug Effect Drug Sensitivity Isolation And Purification Plasmodium Falciparum Simaroubaceae Animal Antimalarials Apocynaceae Brasil Parasitic Sensitivity Tests Plant Extracts Plasmodium Falciparum Simaroubaceae Apocynaceae Aspidosperma Aspidosperma Desmanthum Lepianthes Peltata Picrolemma Piperaceae Plasmodium Falciparum Simaroubaceae |
| description |
In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived. |
| format |
Artigo |
| author |
Andrade Neto, Valter Ferreira de |
| author2 |
Pohlit, Adrian Martin Pinto, Ana Cristina da Silva Silva, Ellen Cristina Costa Nogueira, Karla Lagos Melo, Márcia R.S. Henrique, Marycleuma Campos Amorim, Rodrigo C.N. Silva, Luis Francisco Rocha Costa, Mônica Regina Farias Nunomura, Rita de Cássia Saraiva Nunomura, Sergio Massayoshi Alecrim, Wilson Duarte Alecrim, Maria das Graças Costa Chaves, Francisco Célio Maia Vieira, Pedro Paulo Ribeiro |
| author2Str |
Pohlit, Adrian Martin Pinto, Ana Cristina da Silva Silva, Ellen Cristina Costa Nogueira, Karla Lagos Melo, Márcia R.S. Henrique, Marycleuma Campos Amorim, Rodrigo C.N. Silva, Luis Francisco Rocha Costa, Mônica Regina Farias Nunomura, Rita de Cássia Saraiva Nunomura, Sergio Massayoshi Alecrim, Wilson Duarte Alecrim, Maria das Graças Costa Chaves, Francisco Célio Maia Vieira, Pedro Paulo Ribeiro |
| title |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants |
| title_short |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants |
| title_full |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants |
| title_fullStr |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants |
| title_full_unstemmed |
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants |
| title_sort |
in vitro inhibition of plasmodium falciparum by substances isolated from amazonian antimalarial plants |
| publisher |
Memórias do Instituto Oswaldo Cruz |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/14525 |
| _version_ |
1787142408233811968 |
| score |
11.755432 |