Micronutrient deficiencies and plasmodium vivax malaria among children in the Brazilian Amazon
Background: There is a growing body of evidence linking micronutrient deficiencies and malaria incidence arising mostly from P. falciparum endemic areas. We assessed the impact of micronutrient deficiencies on malaria incidence and vice versa in the Brazilian state of Amazonas. Methodology/Principal...
| Autor principal: | Benzecry, Silvana Gomes |
|---|---|
| Outros Autores: | Alexandre, Márcia Almeida A.Araújo, Vítor-Silva, Sheila, Salinas, Jorge L., Melo, Gisely Cardoso de, Marinho, Helyde Albuquerque, Paes, Angela Tavares, Siqueira, Andre M., Monteiro, Wuelton Marcelo, Lacerda, Marcus V. G., Leite, Heitor Pons |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
PLoS ONE
2020
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| Assuntos: | |
| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/14688 |
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oai:repositorio:1-14688 |
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oai:repositorio:1-14688 Micronutrient deficiencies and plasmodium vivax malaria among children in the Brazilian Amazon Benzecry, Silvana Gomes Alexandre, Márcia Almeida A.Araújo Vítor-Silva, Sheila Salinas, Jorge L. Melo, Gisely Cardoso de Marinho, Helyde Albuquerque Paes, Angela Tavares Siqueira, Andre M. Monteiro, Wuelton Marcelo Lacerda, Marcus V. G. Leite, Heitor Pons Beta Carotene Iron Retinol Trace Element Zinc Beta Carotene Iron Trace Element Zinc Beta Carotene Deficiency Brasil Child Controlled Study Disease Surveillance Female Follow Up Human Infection Risk Intestine Parasite Iron Deficiency Major Clinical Study Male Nutritional Assessment Nutritional Deficiency Nutritional Requirement Parasite Identification Parasite Incidence Plasmodium Vivax Malaria Retinol Deficiency Rural Area Zinc Deficiency Blood Complication Deficiency Isolation And Purification Malaria, Vivax Plasmodium Vivax Child, Preschool Proportional Hazards Model Rural Population Beta Carotene Brasil Child Child, Preschool Female Follow-up Studies Humans Iron Malaria, Vivax Male Micronutrients Nutrition Assessment Plasmodium Vivax Proportional Hazards Models Rural Population Vitamin A Deficiency Zinc Background: There is a growing body of evidence linking micronutrient deficiencies and malaria incidence arising mostly from P. falciparum endemic areas. We assessed the impact of micronutrient deficiencies on malaria incidence and vice versa in the Brazilian state of Amazonas. Methodology/Principal Findings: We evaluated children <10 years old living in rural communities in the state of Amazonas, Brazil, from May 2010 to May 2011. All children were assessed for sociodemographic, anthropometric and laboratory parameters, including vitamin A, beta-carotene, zinc and iron serum levels at the beginning of the study (May 2010) and one year later (May 2011). Children were followed in between using passive surveillance for detection of symptomatic malaria. Those living in the study area at the completion of the observation period were reassessed for micronutrient levels. Univariate Cox-proportional Hazards models were used to assess whether micronutrient deficiencies had an impact on time to first P. vivax malaria episode. We included 95 children median age 4.8 years (interquartile range [IQR]: 2.3-6.6), mostly males (60.0%) and with high maternal illiteracy (72.6%). Vitamin A deficiencies were found in 36% of children, beta-carotene deficiency in 63%, zinc deficiency in 61% and iron deficiency in 51%. Most children (80%) had at least one intestinal parasite. During follow-up, 16 cases of vivax malaria were diagnosed amongst 13 individuals. Micronutrient deficiencies were not associated with increased malaria incidence: vitamin A deficiency [Hazard ratio (HR): 1.51; P-value: 0.45]; beta-carotene [HR: 0.47; P-value: 0.19]; zinc [HR: 1.41; P-value: 0.57] and iron [HR: 2.31; P-value: 0.16]). Upon reevaluation, children with al least one episode of malaria did not present significant changes in micronutrient levels. Conclusion: Micronutrient serum levels were not associated with a higher malaria incidence nor the malaria episode influenced micronutrient levels. Future studies targeting larger populations to assess micronutrients levels in P. vivax endemic areas are warranted in order to validate these results. © 2016 Benzecry et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2020-04-24T17:00:21Z 2020-04-24T17:00:21Z 2016 Artigo https://repositorio.inpa.gov.br/handle/1/14688 10.1371/journal.pone.0151019 en Volume 11, Número 3 Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf PLoS ONE |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Beta Carotene Iron Retinol Trace Element Zinc Beta Carotene Iron Trace Element Zinc Beta Carotene Deficiency Brasil Child Controlled Study Disease Surveillance Female Follow Up Human Infection Risk Intestine Parasite Iron Deficiency Major Clinical Study Male Nutritional Assessment Nutritional Deficiency Nutritional Requirement Parasite Identification Parasite Incidence Plasmodium Vivax Malaria Retinol Deficiency Rural Area Zinc Deficiency Blood Complication Deficiency Isolation And Purification Malaria, Vivax Plasmodium Vivax Child, Preschool Proportional Hazards Model Rural Population Beta Carotene Brasil Child Child, Preschool Female Follow-up Studies Humans Iron Malaria, Vivax Male Micronutrients Nutrition Assessment Plasmodium Vivax Proportional Hazards Models Rural Population Vitamin A Deficiency Zinc |
| spellingShingle |
Beta Carotene Iron Retinol Trace Element Zinc Beta Carotene Iron Trace Element Zinc Beta Carotene Deficiency Brasil Child Controlled Study Disease Surveillance Female Follow Up Human Infection Risk Intestine Parasite Iron Deficiency Major Clinical Study Male Nutritional Assessment Nutritional Deficiency Nutritional Requirement Parasite Identification Parasite Incidence Plasmodium Vivax Malaria Retinol Deficiency Rural Area Zinc Deficiency Blood Complication Deficiency Isolation And Purification Malaria, Vivax Plasmodium Vivax Child, Preschool Proportional Hazards Model Rural Population Beta Carotene Brasil Child Child, Preschool Female Follow-up Studies Humans Iron Malaria, Vivax Male Micronutrients Nutrition Assessment Plasmodium Vivax Proportional Hazards Models Rural Population Vitamin A Deficiency Zinc Benzecry, Silvana Gomes Micronutrient deficiencies and plasmodium vivax malaria among children in the Brazilian Amazon |
| topic_facet |
Beta Carotene Iron Retinol Trace Element Zinc Beta Carotene Iron Trace Element Zinc Beta Carotene Deficiency Brasil Child Controlled Study Disease Surveillance Female Follow Up Human Infection Risk Intestine Parasite Iron Deficiency Major Clinical Study Male Nutritional Assessment Nutritional Deficiency Nutritional Requirement Parasite Identification Parasite Incidence Plasmodium Vivax Malaria Retinol Deficiency Rural Area Zinc Deficiency Blood Complication Deficiency Isolation And Purification Malaria, Vivax Plasmodium Vivax Child, Preschool Proportional Hazards Model Rural Population Beta Carotene Brasil Child Child, Preschool Female Follow-up Studies Humans Iron Malaria, Vivax Male Micronutrients Nutrition Assessment Plasmodium Vivax Proportional Hazards Models Rural Population Vitamin A Deficiency Zinc |
| description |
Background: There is a growing body of evidence linking micronutrient deficiencies and malaria incidence arising mostly from P. falciparum endemic areas. We assessed the impact of micronutrient deficiencies on malaria incidence and vice versa in the Brazilian state of Amazonas. Methodology/Principal Findings: We evaluated children <10 years old living in rural communities in the state of Amazonas, Brazil, from May 2010 to May 2011. All children were assessed for sociodemographic, anthropometric and laboratory parameters, including vitamin A, beta-carotene, zinc and iron serum levels at the beginning of the study (May 2010) and one year later (May 2011). Children were followed in between using passive surveillance for detection of symptomatic malaria. Those living in the study area at the completion of the observation period were reassessed for micronutrient levels. Univariate Cox-proportional Hazards models were used to assess whether micronutrient deficiencies had an impact on time to first P. vivax malaria episode. We included 95 children median age 4.8 years (interquartile range [IQR]: 2.3-6.6), mostly males (60.0%) and with high maternal illiteracy (72.6%). Vitamin A deficiencies were found in 36% of children, beta-carotene deficiency in 63%, zinc deficiency in 61% and iron deficiency in 51%. Most children (80%) had at least one intestinal parasite. During follow-up, 16 cases of vivax malaria were diagnosed amongst 13 individuals. Micronutrient deficiencies were not associated with increased malaria incidence: vitamin A deficiency [Hazard ratio (HR): 1.51; P-value: 0.45]; beta-carotene [HR: 0.47; P-value: 0.19]; zinc [HR: 1.41; P-value: 0.57] and iron [HR: 2.31; P-value: 0.16]). Upon reevaluation, children with al least one episode of malaria did not present significant changes in micronutrient levels. Conclusion: Micronutrient serum levels were not associated with a higher malaria incidence nor the malaria episode influenced micronutrient levels. Future studies targeting larger populations to assess micronutrients levels in P. vivax endemic areas are warranted in order to validate these results. © 2016 Benzecry et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| format |
Artigo |
| author |
Benzecry, Silvana Gomes |
| author2 |
Alexandre, Márcia Almeida A.Araújo Vítor-Silva, Sheila Salinas, Jorge L. Melo, Gisely Cardoso de Marinho, Helyde Albuquerque Paes, Angela Tavares Siqueira, Andre M. Monteiro, Wuelton Marcelo Lacerda, Marcus V. G. Leite, Heitor Pons |
| author2Str |
Alexandre, Márcia Almeida A.Araújo Vítor-Silva, Sheila Salinas, Jorge L. Melo, Gisely Cardoso de Marinho, Helyde Albuquerque Paes, Angela Tavares Siqueira, Andre M. Monteiro, Wuelton Marcelo Lacerda, Marcus V. G. Leite, Heitor Pons |
| title |
Micronutrient deficiencies and plasmodium vivax malaria among children in the Brazilian Amazon |
| title_short |
Micronutrient deficiencies and plasmodium vivax malaria among children in the Brazilian Amazon |
| title_full |
Micronutrient deficiencies and plasmodium vivax malaria among children in the Brazilian Amazon |
| title_fullStr |
Micronutrient deficiencies and plasmodium vivax malaria among children in the Brazilian Amazon |
| title_full_unstemmed |
Micronutrient deficiencies and plasmodium vivax malaria among children in the Brazilian Amazon |
| title_sort |
micronutrient deficiencies and plasmodium vivax malaria among children in the brazilian amazon |
| publisher |
PLoS ONE |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/14688 |
| _version_ |
1787141301589770240 |
| score |
11.755432 |