id oai:repositorio:1-14691
recordtype dspace
spelling oai:repositorio:1-14691 Alleles of HLA-DRB1∗04 associated with pulmonary tuberculosis in Amazon Brazilian population Lima, Dhêmerson Souza de Ogusku, Maurício Morishi Santos, Maria Cristina dos Silva, Cláudia Maria de Melo Almeida, Vanessa Alves de Antunes, Irineide Assumpção Boechat, Antonio Luiz Ramasawmy, Rajendranath Sadahiro, Aya Early Secretory Antigenic Target 6 Hla Drb1 Antigen Hla Drb1 Antigen Hla-drb1*04 Antigen Adult Alcohol Consumption Allele Brasil Brazilian Controlled Study Correlation Analysis Disease Transmission Female Gender Gene Frequency Genetic Association Genetic Susceptibility Hla Drb1 Gene Human Lung Tuberculosis Major Clinical Study Male Nucleotide Sequence Polymerase Chain Reaction Prevalence Smoking Allele Polymorphism, Genetic Genetic Predisposition Genetics Lung Tuberculosis Middle Aged Young Adult Adult Alleles Brasil Female Genetic Predisposition To Disease Hla-drb1 Chains Humans Male Middle Aged Polymorphism, Genetic Tuberculosis, Pulmonary Young Adult Immunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB1∗04 alleles to identify subtypes associated with pulmonary TB and their interaction with risk factors such as alcohol, smoking, and gender in 316 pulmonary TB patients and 306 healthy individuals from the Brazilian Amazon. The HLA-DRB1∗04 was prevalent in patients with pulmonary TB (p<0.0001; OR = 2.94; 95% CI = 2.12 to 4.08). Direct nucleotide sequencing of DRB1 exon 2 identified nine subtypes of HLA-DRB1∗04. The subtype HLA-DRB1∗04:11:01 (p = 0.0019; OR = 2.23; 95% CI = 1.34 to 3.70) was associated with susceptibility to pulmonary TB while DRB1∗04:07:01 (p<0.0001; OR = 0.02; 95% CI = 0.001 to 0.33) to protection. Notably, the interaction between alcohol and HLA-DRB1∗04:11:01 increased the risk for developing pulmonary TB (p = 0.0001; OR = 51.3; 95% CI = 6.81 to 386). Multibacillary pulmonary TB, the clinical presentation of disease transmission, was strongly associated with interaction to alcohol (p = 0.0026; OR = 11.1; 95% CI = 3.99 to 30.9), HLA-DRB1∗04:11:01 (p = 0.0442; OR =2.01; 95% CI = 1.03 to 3.93) and DRB1∗04:92 (p = 0.0112; OR = 8.62; 95% CI = 1.63 to 45.5). These results show that HLA-DRB1∗04 are associated with pulmonary TB. Interestingly, three subtypes, DRB1∗04:07:01, DRB1∗04:11:01 and DRB1∗04:92 of the HLA-DRB1∗04 could be potential immunogenetic markers that may help to explain mechanisms involved in disease development. © 2016 Souza de Lima et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2020-04-24T17:00:24Z 2020-04-24T17:00:24Z 2016 Artigo https://repositorio.inpa.gov.br/handle/1/14691 10.1371/journal.pone.0147543 en Volume 11, Número 2 Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf PLoS ONE
institution Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional
collection INPA-RI
language English
topic Early Secretory Antigenic Target 6
Hla Drb1 Antigen
Hla Drb1 Antigen
Hla-drb1*04 Antigen
Adult
Alcohol Consumption
Allele
Brasil
Brazilian
Controlled Study
Correlation Analysis
Disease Transmission
Female
Gender
Gene Frequency
Genetic Association
Genetic Susceptibility
Hla Drb1 Gene
Human
Lung Tuberculosis
Major Clinical Study
Male
Nucleotide Sequence
Polymerase Chain Reaction
Prevalence
Smoking
Allele
Polymorphism, Genetic
Genetic Predisposition
Genetics
Lung Tuberculosis
Middle Aged
Young Adult
Adult
Alleles
Brasil
Female
Genetic Predisposition To Disease
Hla-drb1 Chains
Humans
Male
Middle Aged
Polymorphism, Genetic
Tuberculosis, Pulmonary
Young Adult
spellingShingle Early Secretory Antigenic Target 6
Hla Drb1 Antigen
Hla Drb1 Antigen
Hla-drb1*04 Antigen
Adult
Alcohol Consumption
Allele
Brasil
Brazilian
Controlled Study
Correlation Analysis
Disease Transmission
Female
Gender
Gene Frequency
Genetic Association
Genetic Susceptibility
Hla Drb1 Gene
Human
Lung Tuberculosis
Major Clinical Study
Male
Nucleotide Sequence
Polymerase Chain Reaction
Prevalence
Smoking
Allele
Polymorphism, Genetic
Genetic Predisposition
Genetics
Lung Tuberculosis
Middle Aged
Young Adult
Adult
Alleles
Brasil
Female
Genetic Predisposition To Disease
Hla-drb1 Chains
Humans
Male
Middle Aged
Polymorphism, Genetic
Tuberculosis, Pulmonary
Young Adult
Lima, Dhêmerson Souza de
Alleles of HLA-DRB1∗04 associated with pulmonary tuberculosis in Amazon Brazilian population
topic_facet Early Secretory Antigenic Target 6
Hla Drb1 Antigen
Hla Drb1 Antigen
Hla-drb1*04 Antigen
Adult
Alcohol Consumption
Allele
Brasil
Brazilian
Controlled Study
Correlation Analysis
Disease Transmission
Female
Gender
Gene Frequency
Genetic Association
Genetic Susceptibility
Hla Drb1 Gene
Human
Lung Tuberculosis
Major Clinical Study
Male
Nucleotide Sequence
Polymerase Chain Reaction
Prevalence
Smoking
Allele
Polymorphism, Genetic
Genetic Predisposition
Genetics
Lung Tuberculosis
Middle Aged
Young Adult
Adult
Alleles
Brasil
Female
Genetic Predisposition To Disease
Hla-drb1 Chains
Humans
Male
Middle Aged
Polymorphism, Genetic
Tuberculosis, Pulmonary
Young Adult
description Immunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB1∗04 alleles to identify subtypes associated with pulmonary TB and their interaction with risk factors such as alcohol, smoking, and gender in 316 pulmonary TB patients and 306 healthy individuals from the Brazilian Amazon. The HLA-DRB1∗04 was prevalent in patients with pulmonary TB (p<0.0001; OR = 2.94; 95% CI = 2.12 to 4.08). Direct nucleotide sequencing of DRB1 exon 2 identified nine subtypes of HLA-DRB1∗04. The subtype HLA-DRB1∗04:11:01 (p = 0.0019; OR = 2.23; 95% CI = 1.34 to 3.70) was associated with susceptibility to pulmonary TB while DRB1∗04:07:01 (p<0.0001; OR = 0.02; 95% CI = 0.001 to 0.33) to protection. Notably, the interaction between alcohol and HLA-DRB1∗04:11:01 increased the risk for developing pulmonary TB (p = 0.0001; OR = 51.3; 95% CI = 6.81 to 386). Multibacillary pulmonary TB, the clinical presentation of disease transmission, was strongly associated with interaction to alcohol (p = 0.0026; OR = 11.1; 95% CI = 3.99 to 30.9), HLA-DRB1∗04:11:01 (p = 0.0442; OR =2.01; 95% CI = 1.03 to 3.93) and DRB1∗04:92 (p = 0.0112; OR = 8.62; 95% CI = 1.63 to 45.5). These results show that HLA-DRB1∗04 are associated with pulmonary TB. Interestingly, three subtypes, DRB1∗04:07:01, DRB1∗04:11:01 and DRB1∗04:92 of the HLA-DRB1∗04 could be potential immunogenetic markers that may help to explain mechanisms involved in disease development. © 2016 Souza de Lima et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
format Artigo
author Lima, Dhêmerson Souza de
author2 Ogusku, Maurício Morishi
Santos, Maria Cristina dos
Silva, Cláudia Maria de Melo
Almeida, Vanessa Alves de
Antunes, Irineide Assumpção
Boechat, Antonio Luiz
Ramasawmy, Rajendranath
Sadahiro, Aya
author2Str Ogusku, Maurício Morishi
Santos, Maria Cristina dos
Silva, Cláudia Maria de Melo
Almeida, Vanessa Alves de
Antunes, Irineide Assumpção
Boechat, Antonio Luiz
Ramasawmy, Rajendranath
Sadahiro, Aya
title Alleles of HLA-DRB1∗04 associated with pulmonary tuberculosis in Amazon Brazilian population
title_short Alleles of HLA-DRB1∗04 associated with pulmonary tuberculosis in Amazon Brazilian population
title_full Alleles of HLA-DRB1∗04 associated with pulmonary tuberculosis in Amazon Brazilian population
title_fullStr Alleles of HLA-DRB1∗04 associated with pulmonary tuberculosis in Amazon Brazilian population
title_full_unstemmed Alleles of HLA-DRB1∗04 associated with pulmonary tuberculosis in Amazon Brazilian population
title_sort alleles of hla-drb1∗04 associated with pulmonary tuberculosis in amazon brazilian population
publisher PLoS ONE
publishDate 2020
url https://repositorio.inpa.gov.br/handle/1/14691
_version_ 1787142745734774784
score 11.653393

Registros relacionados