Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil
Introduction: Human T-lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in Brazil, but few studies have investigated the seroprevalence of HTLV and its subtypes among blood donors in the capital city Manaus, Amazonas State, Brazil. Aim: To estimate the seroprevalence of HTLV-1/2 and to identify...
| Autor principal: | Morais, Márcia Poinho Encarnação de |
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| Outros Autores: | Gato, Cynara Melo, Maciel, Lucinei Alves, Lalwani, Pritesh, Costa, Cristóvão Alves, Lalwani, Jaila Dias Borges |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Revista do Instituto de Medicina Tropical de Sao Paulo
2020
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https://repositorio.inpa.gov.br/handle/1/15774 |
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oai:repositorio:1-15774 Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil Morais, Márcia Poinho Encarnação de Gato, Cynara Melo Maciel, Lucinei Alves Lalwani, Pritesh Costa, Cristóvão Alves Lalwani, Jaila Dias Borges Adult Blood Donor Brasil Cross-sectional Study Enzyme-linked Immunosorbent Assay Female Htlv-1 Infection Htlv-2 Infection Human Human T-lymphotropic Virus 1 Major Clinical Study Male Primate T-lymphotropic Virus 2 Seroprevalence Social Status Structured Questionnaire Western Blotting Adolescent Blood Donor Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Isolation And Purification Middle Aged Prevalence Seroepidemiology Statistics And Numerical Data Virology Young Adult Adolescent Adult Blood Donors Western Blotting Brasil Cross-sectional Studies Enzyme-linked Immunosorbent Assay Female Htlv-ii Infections Htlv-ii Infections Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Humans Male Middle Aged Prevalence Seroepidemiologic Studies Young Adult Introduction: Human T-lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in Brazil, but few studies have investigated the seroprevalence of HTLV and its subtypes among blood donors in the capital city Manaus, Amazonas State, Brazil. Aim: To estimate the seroprevalence of HTLV-1/2 and to identify circulating subtypes among blood donors in Manaus. Materials and Methods: Blood donors (2001-2003) were screened for HTLV-1/2 antibodies by ELISA. Positive results were confirmed and subtyped by Western blot assays. Prevalence rates were calculated and compared with demographic data. Results: Among the 87,402 individuals screened, 116 (0.13%) were seropositive for HTLV-1/2. A second sample (76/116) was collected and retested by HTLV-1/2 ELISA, of which only 41/76 were positive. Western blot confirmed HTLV infection in 24/41 retested blood donors [HTLV-1 (n=16), HTLV-2 (n=5) and HTLV-untypable (n=3)]. Discussion: HTLV-1 and HTLV-2 are prevalent among blood donors in Manaus. However, additional studies are needed to comprehend the epidemiology of HTLV-1/2 in Amazonas not only to understand the pathophysiology of the disease providing adequate medical assistance, but also to reduce or block virus transmission. © 2017, Instituto de Medicina Tropical de Sao Paulo. All rights reserved. 2020-05-18T20:46:09Z 2020-05-18T20:46:09Z 2017 Artigo https://repositorio.inpa.gov.br/handle/1/15774 10.1590/S1678-9946201759080 en Volume 59 Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Revista do Instituto de Medicina Tropical de Sao Paulo |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Adult Blood Donor Brasil Cross-sectional Study Enzyme-linked Immunosorbent Assay Female Htlv-1 Infection Htlv-2 Infection Human Human T-lymphotropic Virus 1 Major Clinical Study Male Primate T-lymphotropic Virus 2 Seroprevalence Social Status Structured Questionnaire Western Blotting Adolescent Blood Donor Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Isolation And Purification Middle Aged Prevalence Seroepidemiology Statistics And Numerical Data Virology Young Adult Adolescent Adult Blood Donors Western Blotting Brasil Cross-sectional Studies Enzyme-linked Immunosorbent Assay Female Htlv-ii Infections Htlv-ii Infections Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Humans Male Middle Aged Prevalence Seroepidemiologic Studies Young Adult |
| spellingShingle |
Adult Blood Donor Brasil Cross-sectional Study Enzyme-linked Immunosorbent Assay Female Htlv-1 Infection Htlv-2 Infection Human Human T-lymphotropic Virus 1 Major Clinical Study Male Primate T-lymphotropic Virus 2 Seroprevalence Social Status Structured Questionnaire Western Blotting Adolescent Blood Donor Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Isolation And Purification Middle Aged Prevalence Seroepidemiology Statistics And Numerical Data Virology Young Adult Adolescent Adult Blood Donors Western Blotting Brasil Cross-sectional Studies Enzyme-linked Immunosorbent Assay Female Htlv-ii Infections Htlv-ii Infections Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Humans Male Middle Aged Prevalence Seroepidemiologic Studies Young Adult Morais, Márcia Poinho Encarnação de Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil |
| topic_facet |
Adult Blood Donor Brasil Cross-sectional Study Enzyme-linked Immunosorbent Assay Female Htlv-1 Infection Htlv-2 Infection Human Human T-lymphotropic Virus 1 Major Clinical Study Male Primate T-lymphotropic Virus 2 Seroprevalence Social Status Structured Questionnaire Western Blotting Adolescent Blood Donor Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Isolation And Purification Middle Aged Prevalence Seroepidemiology Statistics And Numerical Data Virology Young Adult Adolescent Adult Blood Donors Western Blotting Brasil Cross-sectional Studies Enzyme-linked Immunosorbent Assay Female Htlv-ii Infections Htlv-ii Infections Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Humans Male Middle Aged Prevalence Seroepidemiologic Studies Young Adult |
| description |
Introduction: Human T-lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in Brazil, but few studies have investigated the seroprevalence of HTLV and its subtypes among blood donors in the capital city Manaus, Amazonas State, Brazil. Aim: To estimate the seroprevalence of HTLV-1/2 and to identify circulating subtypes among blood donors in Manaus. Materials and Methods: Blood donors (2001-2003) were screened for HTLV-1/2 antibodies by ELISA. Positive results were confirmed and subtyped by Western blot assays. Prevalence rates were calculated and compared with demographic data. Results: Among the 87,402 individuals screened, 116 (0.13%) were seropositive for HTLV-1/2. A second sample (76/116) was collected and retested by HTLV-1/2 ELISA, of which only 41/76 were positive. Western blot confirmed HTLV infection in 24/41 retested blood donors [HTLV-1 (n=16), HTLV-2 (n=5) and HTLV-untypable (n=3)]. Discussion: HTLV-1 and HTLV-2 are prevalent among blood donors in Manaus. However, additional studies are needed to comprehend the epidemiology of HTLV-1/2 in Amazonas not only to understand the pathophysiology of the disease providing adequate medical assistance, but also to reduce or block virus transmission. © 2017, Instituto de Medicina Tropical de Sao Paulo. All rights reserved. |
| format |
Artigo |
| author |
Morais, Márcia Poinho Encarnação de |
| author2 |
Gato, Cynara Melo Maciel, Lucinei Alves Lalwani, Pritesh Costa, Cristóvão Alves Lalwani, Jaila Dias Borges |
| author2Str |
Gato, Cynara Melo Maciel, Lucinei Alves Lalwani, Pritesh Costa, Cristóvão Alves Lalwani, Jaila Dias Borges |
| title |
Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil |
| title_short |
Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil |
| title_full |
Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil |
| title_fullStr |
Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil |
| title_full_unstemmed |
Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil |
| title_sort |
prevalence of human t-lymphotropic virus type 1 and 2 among blood donors in manaus, amazonas state, brazil |
| publisher |
Revista do Instituto de Medicina Tropical de Sao Paulo |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/15774 |
| _version_ |
1787141309483450368 |
| score |
11.755432 |