The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil
The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patien...
| Autor principal: | Espir, Thaís Tibery |
|---|---|
| Outros Autores: | Figueira, Luanda de Paula, Naiff, Maricleide de Farias, Costa, Allyson Guimarães da, Ramalho-Ortigão, Marcelo, Malheiro, Adriana, Franco, A. M. |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Journal of Immunology Research
2020
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| Assuntos: | |
| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/15978 |
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oai:repositorio:1-15978 |
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oai:repositorio:1-15978 The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil Espir, Thaís Tibery Figueira, Luanda de Paula Naiff, Maricleide de Farias Costa, Allyson Guimarães da Ramalho-Ortigão, Marcelo Malheiro, Adriana Franco, A. M. Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Autacoid Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Adult Antiinflammatory Activity Brasil Clinical Comparative Study Controlled Study Female Human Leishmania Leishmania Naiffi Male Nonhuman Protein Blood Level Protein Expression Skin Leishmaniasis Adolescent Blood Classification Flow Cytometry Host Parasite Interaction Immunology Middle Aged Parasitology Physiology Skin Leishmaniasis Species Difference Young Adult Adolescent Adult Brasil Cytokines Female Flow Cytometry Host-parasite Interactions Humans Inflammation Mediators Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Leishmania Leishmania Guyanensis Leishmaniasis, Cutaneous Male Middle Aged Species Specificity Tumor Necrosis Factor-alpha Young Adult The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified as Leishmania guyanensis, L. naiffi, and L. amazonensis. Most (64%) of the patients were male ranging in age from 18 to 58 years. Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to the Leishmania species. Infection caused by L. guyanensis accounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection by L. amazonensis. Patients with infection caused by L. naiffi showed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed. © 2014 Thaís Tibery Espir et al. 2020-05-21T20:06:19Z 2020-05-21T20:06:19Z 2014 Artigo https://repositorio.inpa.gov.br/handle/1/15978 10.1155/2014/481750 en Volume 2014 Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Journal of Immunology Research |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Autacoid Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Adult Antiinflammatory Activity Brasil Clinical Comparative Study Controlled Study Female Human Leishmania Leishmania Naiffi Male Nonhuman Protein Blood Level Protein Expression Skin Leishmaniasis Adolescent Blood Classification Flow Cytometry Host Parasite Interaction Immunology Middle Aged Parasitology Physiology Skin Leishmaniasis Species Difference Young Adult Adolescent Adult Brasil Cytokines Female Flow Cytometry Host-parasite Interactions Humans Inflammation Mediators Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Leishmania Leishmania Guyanensis Leishmaniasis, Cutaneous Male Middle Aged Species Specificity Tumor Necrosis Factor-alpha Young Adult |
| spellingShingle |
Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Autacoid Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Adult Antiinflammatory Activity Brasil Clinical Comparative Study Controlled Study Female Human Leishmania Leishmania Naiffi Male Nonhuman Protein Blood Level Protein Expression Skin Leishmaniasis Adolescent Blood Classification Flow Cytometry Host Parasite Interaction Immunology Middle Aged Parasitology Physiology Skin Leishmaniasis Species Difference Young Adult Adolescent Adult Brasil Cytokines Female Flow Cytometry Host-parasite Interactions Humans Inflammation Mediators Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Leishmania Leishmania Guyanensis Leishmaniasis, Cutaneous Male Middle Aged Species Specificity Tumor Necrosis Factor-alpha Young Adult Espir, Thaís Tibery The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
| topic_facet |
Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Autacoid Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Adult Antiinflammatory Activity Brasil Clinical Comparative Study Controlled Study Female Human Leishmania Leishmania Naiffi Male Nonhuman Protein Blood Level Protein Expression Skin Leishmaniasis Adolescent Blood Classification Flow Cytometry Host Parasite Interaction Immunology Middle Aged Parasitology Physiology Skin Leishmaniasis Species Difference Young Adult Adolescent Adult Brasil Cytokines Female Flow Cytometry Host-parasite Interactions Humans Inflammation Mediators Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Leishmania Leishmania Guyanensis Leishmaniasis, Cutaneous Male Middle Aged Species Specificity Tumor Necrosis Factor-alpha Young Adult |
| description |
The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species of Leishmania in Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified as Leishmania guyanensis, L. naiffi, and L. amazonensis. Most (64%) of the patients were male ranging in age from 18 to 58 years. Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to the Leishmania species. Infection caused by L. guyanensis accounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection by L. amazonensis. Patients with infection caused by L. naiffi showed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed. © 2014 Thaís Tibery Espir et al. |
| format |
Artigo |
| author |
Espir, Thaís Tibery |
| author2 |
Figueira, Luanda de Paula Naiff, Maricleide de Farias Costa, Allyson Guimarães da Ramalho-Ortigão, Marcelo Malheiro, Adriana Franco, A. M. |
| author2Str |
Figueira, Luanda de Paula Naiff, Maricleide de Farias Costa, Allyson Guimarães da Ramalho-Ortigão, Marcelo Malheiro, Adriana Franco, A. M. |
| title |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
| title_short |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
| title_full |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
| title_fullStr |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
| title_full_unstemmed |
The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil |
| title_sort |
role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with cutaneous leishmaniasis in amazonas state, brazil |
| publisher |
Journal of Immunology Research |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/15978 |
| _version_ |
1787144888922406912 |
| score |
11.653393 |