Chemical constituents from stems of simaba guianensis subesp. ecaudata (cronquist)
Simaba guianensis subesp. ecaudata (Simaroubaceae) is a tree found in the Brazilian Amazon. This work describes for the first time the fractionation of stems of this species that resulted in the isolation of the cytotoxic triterpene piscidinol A, the alkaloid 9-methoxycanthin-6-one, caryophyllene ox...
| Autor principal: | Nunomura, Rita de Cássia Saraiva |
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| Outros Autores: | Pinto, Ângelo da Cunha, Nunomura, Sergio Massayoshi, Pohlit, Adrian Martin, Amaral, Aná Cláudia Fernandes |
| Grau: | Artigo |
| Idioma: | pt_BR |
| Publicado em: |
Química Nova
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/16092 |
| Resumo: |
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Simaba guianensis subesp. ecaudata (Simaroubaceae) is a tree found in the Brazilian Amazon. This work describes for the first time the fractionation of stems of this species that resulted in the isolation of the cytotoxic triterpene piscidinol A, the alkaloid 9-methoxycanthin-6-one, caryophyllene oxide, also isolated for the first time from this species and a new alkaloid (6-methoxy-(9H-β-carbolin-1-il)-(Z)-2-propenoic acid). Quantification of 9-methoxycanthin-6-one in different extracts and fractions of stems of S. guianensis by high performance liquid chromatography was also performed. The concentration of 9-methoxycanthin-6-one in methanolic and aqueous extracts were inferior to the known cytotoxic concentration of this compound. |