Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
Phytochemical investigation from roots of Spathelia excelsa yielded the chromones 10(2,3-epoxy-3-methylbutanyl)spatheliachromen and 10(2,3-dihydroxy-3-methylbutanyl) methoxyspatheliacromen (5-methoxyspatheliabischromen); limonoid deacetylspathelin and protolimonoid C-21-epimers 3β-angeloyloxy-7α,24,...
| Autor principal: | Moreira, Wagner Alan dos Santos |
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| Outros Autores: | Lima, Maria da Paz, Ferreira, Antonio Gilberto, Piloto Ferreira, Izabel Cristina, Nakamura, Celso Vataru |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Journal of the Brazilian Chemical Society
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/16300 |
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oai:repositorio:1-16300 |
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oai:repositorio:1-16300 Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity Moreira, Wagner Alan dos Santos Lima, Maria da Paz Ferreira, Antonio Gilberto Piloto Ferreira, Izabel Cristina Nakamura, Celso Vataru Phytochemical investigation from roots of Spathelia excelsa yielded the chromones 10(2,3-epoxy-3-methylbutanyl)spatheliachromen and 10(2,3-dihydroxy-3-methylbutanyl) methoxyspatheliacromen (5-methoxyspatheliabischromen); limonoid deacetylspathelin and protolimonoid C-21-epimers 3β-angeloyloxy-7α,24,25-trihydroxy-21,23-oxide-14,18-cycloapotirucall-21-hemiacetal; the alkaloids 7,8-dimethoxyflindersin, casimiroin and N-methyl-4,7,8-trimethoxyquinolin-2(1H)-one, besides a mixture of β-sitosterol and stigmasterol. Assays on promastigote forms of Leishmania braziliensis, deacetylspathelin showed moderate activity; and on epimastigote forms of Trypanossoma cruzi, 10(2,3-epoxy-3-methylbutanyl)spatheliachromen exhibited strong activity (IC50 = 11 μg mL-1). ©2009 Sociedade Brasileira de Química. 2020-06-03T01:55:49Z 2020-06-03T01:55:49Z 2009 Artigo https://repositorio.inpa.gov.br/handle/1/16300 en Volume 20, Número 6, Pags. 1089-1094 Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ application/pdf Journal of the Brazilian Chemical Society |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| description |
Phytochemical investigation from roots of Spathelia excelsa yielded the chromones 10(2,3-epoxy-3-methylbutanyl)spatheliachromen and 10(2,3-dihydroxy-3-methylbutanyl) methoxyspatheliacromen (5-methoxyspatheliabischromen); limonoid deacetylspathelin and protolimonoid C-21-epimers 3β-angeloyloxy-7α,24,25-trihydroxy-21,23-oxide-14,18-cycloapotirucall-21-hemiacetal; the alkaloids 7,8-dimethoxyflindersin, casimiroin and N-methyl-4,7,8-trimethoxyquinolin-2(1H)-one, besides a mixture of β-sitosterol and stigmasterol. Assays on promastigote forms of Leishmania braziliensis, deacetylspathelin showed moderate activity; and on epimastigote forms of Trypanossoma cruzi, 10(2,3-epoxy-3-methylbutanyl)spatheliachromen exhibited strong activity (IC50 = 11 μg mL-1). ©2009 Sociedade Brasileira de Química. |
| format |
Artigo |
| author |
Moreira, Wagner Alan dos Santos |
| spellingShingle |
Moreira, Wagner Alan dos Santos Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity |
| author2 |
Lima, Maria da Paz Ferreira, Antonio Gilberto Piloto Ferreira, Izabel Cristina Nakamura, Celso Vataru |
| author2Str |
Lima, Maria da Paz Ferreira, Antonio Gilberto Piloto Ferreira, Izabel Cristina Nakamura, Celso Vataru |
| title |
Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity |
| title_short |
Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity |
| title_full |
Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity |
| title_fullStr |
Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity |
| title_full_unstemmed |
Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity |
| title_sort |
chemical constituents from the roots of spathelia excelsa and their antiprotozoal activity |
| publisher |
Journal of the Brazilian Chemical Society |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/16300 |
| _version_ |
1787144117637087232 |
| score |
11.755432 |