Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche
Collared peccaries (Tayassu tajacu) present a unique testis cytoarchitecture, where Leydig cells (LC) are mainly located in cords around the seminiferous tubules (ST) lobes. This peculiar arrangement is very useful to better investigate and understand the role of LC in spermatogonial stem cells (SSC...
| Autor principal: | Lara, Nathália L.M. |
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| Outros Autores: | Costa, Guilherme M.J., Avelar, Gleide Fernandes, Guimarães, D. A.A., França, Luiz Renato de |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
General and Comparative Endocrinology
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/16726 |
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oai:repositorio:1-16726 |
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oai:repositorio:1-16726 Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche Lara, Nathália L.M. Costa, Guilherme M.J. Avelar, Gleide Fernandes Guimarães, D. A.A. França, Luiz Renato de Estradiol Glial Cell Line Derived Neurotrophic Factor Receptor Peptides And Proteins Protein Gfra1 Protein Nanos1 Protein Nanos2 Testosterone Unclassified Drug Biological Marker Hormone Adolescent Adult Animals Cell Cell Proliferation Fetus Development Leydig Cell Male Mammal Newborn Nonhuman Postnatal Development Priority Journal Protein Expression Puberty Sertoli Cell Spermatogonium Stem Cell Niche Tayassu Tajacu Testis Development Anatomy And Histology Animals Artiodactyla Body Weight Cytology Growth, Development And Aging Metabolism Organ Size Phenotype Seminiferous Tubule Spermatogenesis Spermatogonium Stem Cell Stem Cell Niche Testis Animal Artiodactyla Biomarkers Body Weight Hormones Male Organ Size Phenotype Seminiferous Tubules Sertoli Cells Spermatogenesis Spermatogonia Stem Cell Niche Stem Cells Testis Collared peccaries (Tayassu tajacu) present a unique testis cytoarchitecture, where Leydig cells (LC) are mainly located in cords around the seminiferous tubules (ST) lobes. This peculiar arrangement is very useful to better investigate and understand the role of LC in spermatogonial stem cells (SSCs) biology and niche. Recent studies from our laboratory using adult peccaries have shown that the undifferentiated type A spermatogonia (A und or SSCs) are preferentially located in ST regions adjacent to the intertubular compartment without LC. Following these studies, our aims were to investigate the collared peccary postnatal testis development, from birth to adulthood, with emphasis on the establishment of LC cytoarchitecture and the SSCs niche. Our findings demonstrated that the unique LC cytoarchitecture is already present in the neonate peccary's testis, indicating that this arrangement is established during fetal development. Based on the most advanced germ cell type present at each time period evaluated, puberty (the first sperm release in the ST lumen) in this species was reached at around one year of age, being preceded by high levels of estradiol and testosterone and the end of Sertoli cell proliferation. Almost all gonocytes and SSCs expressed Nanos1, Nanos2 and GFRA1. The analysis of SSCs preferential location indicated that the establishment of SSCs niche is coincident with the occurrence of puberty. Taken together, our findings reinforced and extended the importance of the collared peccary as an animal model to investigate testis function in mammals, particularly the aspects related to testis organogenesis and the SSCs biology and niche. © 2018 Elsevier Inc. 2020-06-15T21:35:59Z 2020-06-15T21:35:59Z 2019 Artigo https://repositorio.inpa.gov.br/handle/1/16726 10.1016/j.ygcen.2018.05.013 en Volume 273, Pags. 98-107 Restrito General and Comparative Endocrinology |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Estradiol Glial Cell Line Derived Neurotrophic Factor Receptor Peptides And Proteins Protein Gfra1 Protein Nanos1 Protein Nanos2 Testosterone Unclassified Drug Biological Marker Hormone Adolescent Adult Animals Cell Cell Proliferation Fetus Development Leydig Cell Male Mammal Newborn Nonhuman Postnatal Development Priority Journal Protein Expression Puberty Sertoli Cell Spermatogonium Stem Cell Niche Tayassu Tajacu Testis Development Anatomy And Histology Animals Artiodactyla Body Weight Cytology Growth, Development And Aging Metabolism Organ Size Phenotype Seminiferous Tubule Spermatogenesis Spermatogonium Stem Cell Stem Cell Niche Testis Animal Artiodactyla Biomarkers Body Weight Hormones Male Organ Size Phenotype Seminiferous Tubules Sertoli Cells Spermatogenesis Spermatogonia Stem Cell Niche Stem Cells Testis |
| spellingShingle |
Estradiol Glial Cell Line Derived Neurotrophic Factor Receptor Peptides And Proteins Protein Gfra1 Protein Nanos1 Protein Nanos2 Testosterone Unclassified Drug Biological Marker Hormone Adolescent Adult Animals Cell Cell Proliferation Fetus Development Leydig Cell Male Mammal Newborn Nonhuman Postnatal Development Priority Journal Protein Expression Puberty Sertoli Cell Spermatogonium Stem Cell Niche Tayassu Tajacu Testis Development Anatomy And Histology Animals Artiodactyla Body Weight Cytology Growth, Development And Aging Metabolism Organ Size Phenotype Seminiferous Tubule Spermatogenesis Spermatogonium Stem Cell Stem Cell Niche Testis Animal Artiodactyla Biomarkers Body Weight Hormones Male Organ Size Phenotype Seminiferous Tubules Sertoli Cells Spermatogenesis Spermatogonia Stem Cell Niche Stem Cells Testis Lara, Nathália L.M. Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche |
| topic_facet |
Estradiol Glial Cell Line Derived Neurotrophic Factor Receptor Peptides And Proteins Protein Gfra1 Protein Nanos1 Protein Nanos2 Testosterone Unclassified Drug Biological Marker Hormone Adolescent Adult Animals Cell Cell Proliferation Fetus Development Leydig Cell Male Mammal Newborn Nonhuman Postnatal Development Priority Journal Protein Expression Puberty Sertoli Cell Spermatogonium Stem Cell Niche Tayassu Tajacu Testis Development Anatomy And Histology Animals Artiodactyla Body Weight Cytology Growth, Development And Aging Metabolism Organ Size Phenotype Seminiferous Tubule Spermatogenesis Spermatogonium Stem Cell Stem Cell Niche Testis Animal Artiodactyla Biomarkers Body Weight Hormones Male Organ Size Phenotype Seminiferous Tubules Sertoli Cells Spermatogenesis Spermatogonia Stem Cell Niche Stem Cells Testis |
| description |
Collared peccaries (Tayassu tajacu) present a unique testis cytoarchitecture, where Leydig cells (LC) are mainly located in cords around the seminiferous tubules (ST) lobes. This peculiar arrangement is very useful to better investigate and understand the role of LC in spermatogonial stem cells (SSCs) biology and niche. Recent studies from our laboratory using adult peccaries have shown that the undifferentiated type A spermatogonia (A und or SSCs) are preferentially located in ST regions adjacent to the intertubular compartment without LC. Following these studies, our aims were to investigate the collared peccary postnatal testis development, from birth to adulthood, with emphasis on the establishment of LC cytoarchitecture and the SSCs niche. Our findings demonstrated that the unique LC cytoarchitecture is already present in the neonate peccary's testis, indicating that this arrangement is established during fetal development. Based on the most advanced germ cell type present at each time period evaluated, puberty (the first sperm release in the ST lumen) in this species was reached at around one year of age, being preceded by high levels of estradiol and testosterone and the end of Sertoli cell proliferation. Almost all gonocytes and SSCs expressed Nanos1, Nanos2 and GFRA1. The analysis of SSCs preferential location indicated that the establishment of SSCs niche is coincident with the occurrence of puberty. Taken together, our findings reinforced and extended the importance of the collared peccary as an animal model to investigate testis function in mammals, particularly the aspects related to testis organogenesis and the SSCs biology and niche. © 2018 Elsevier Inc. |
| format |
Artigo |
| author |
Lara, Nathália L.M. |
| author2 |
Costa, Guilherme M.J. Avelar, Gleide Fernandes Guimarães, D. A.A. França, Luiz Renato de |
| author2Str |
Costa, Guilherme M.J. Avelar, Gleide Fernandes Guimarães, D. A.A. França, Luiz Renato de |
| title |
Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche |
| title_short |
Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche |
| title_full |
Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche |
| title_fullStr |
Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche |
| title_full_unstemmed |
Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche |
| title_sort |
postnatal testis development in the collared peccary (tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche |
| publisher |
General and Comparative Endocrinology |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/16726 |
| _version_ |
1787142423578673152 |
| score |
11.755432 |