Effects of neuroactive drugs in the discharge patterns of microsternarchus (hypopomidae: gymnotiformes) electric organ
Considering the conserved nature of synaptic physiology among vertebrates, we tested the effects of three psychotropics (diazepam, doxapram, and nicotine) on Microsternarchus cf. bilineatus, measuring 10 parameters associated to the electric organ discharges rhythm and waveform before and after the...
| Autor principal: | Jesus, Isac Silva de |
|---|---|
| Outros Autores: | Ferreira, Milena, Silva-Júnior, Urbano Lopes, Alves-Gomes, José Antônio |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Zebrafish
2020
|
| Assuntos: | |
| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/17003 |
| id |
oai:repositorio:1-17003 |
|---|---|
| recordtype |
dspace |
| spelling |
oai:repositorio:1-17003 Effects of neuroactive drugs in the discharge patterns of microsternarchus (hypopomidae: gymnotiformes) electric organ Jesus, Isac Silva de Ferreira, Milena Silva-Júnior, Urbano Lopes Alves-Gomes, José Antônio Anticonvulsive Agent Central Stimulant Agent Diazepam Doxapram Nicotine Nicotinic Agent Animals Behavior, Animals Central Nervous System Drug Effects Electric Organ Gymnotiformes Physiology Animal Anticonvulsants Behavior, Animals Central Nervous System Central Nervous System Stimulants Diazepam Doxapram Electric Organ Gymnotiformes Nicotine Nicotinic Agonists Considering the conserved nature of synaptic physiology among vertebrates, we tested the effects of three psychotropics (diazepam, doxapram, and nicotine) on Microsternarchus cf. bilineatus, measuring 10 parameters associated to the electric organ discharges rhythm and waveform before and after the administration of each drug and a control group. There were statistically significant differences (p < 0.005) among all the experimental groups, F (70, 22619.25) = 77.7, between the two experimental phases within their respective drug treatment, F (80, 24604.51) = 16.0, and among the six experimental hours within their respective phases and groups, F (320, 37124.15) = 4.1. We observed a common general trend of reduction in the electric organ's (EO) firing rate, regardless of the expected stimulant or depressor effect of the drugs on the central nervous system (CNS). The intensity of the response changed with the treatment. The observed changes in the fishes' behavior may be a result of the drugs' direct action on the CNS or a combination of this with systemic effects of each substance tested, also in the EO. © Copyright 2017, Mary Ann Liebert, Inc. 2017. 2020-06-15T21:37:59Z 2020-06-15T21:37:59Z 2017 Artigo https://repositorio.inpa.gov.br/handle/1/17003 10.1089/zeb.2017.1459 en Volume 14, Número 6, Pags. 526-535 Restrito Zebrafish |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Anticonvulsive Agent Central Stimulant Agent Diazepam Doxapram Nicotine Nicotinic Agent Animals Behavior, Animals Central Nervous System Drug Effects Electric Organ Gymnotiformes Physiology Animal Anticonvulsants Behavior, Animals Central Nervous System Central Nervous System Stimulants Diazepam Doxapram Electric Organ Gymnotiformes Nicotine Nicotinic Agonists |
| spellingShingle |
Anticonvulsive Agent Central Stimulant Agent Diazepam Doxapram Nicotine Nicotinic Agent Animals Behavior, Animals Central Nervous System Drug Effects Electric Organ Gymnotiformes Physiology Animal Anticonvulsants Behavior, Animals Central Nervous System Central Nervous System Stimulants Diazepam Doxapram Electric Organ Gymnotiformes Nicotine Nicotinic Agonists Jesus, Isac Silva de Effects of neuroactive drugs in the discharge patterns of microsternarchus (hypopomidae: gymnotiformes) electric organ |
| topic_facet |
Anticonvulsive Agent Central Stimulant Agent Diazepam Doxapram Nicotine Nicotinic Agent Animals Behavior, Animals Central Nervous System Drug Effects Electric Organ Gymnotiformes Physiology Animal Anticonvulsants Behavior, Animals Central Nervous System Central Nervous System Stimulants Diazepam Doxapram Electric Organ Gymnotiformes Nicotine Nicotinic Agonists |
| description |
Considering the conserved nature of synaptic physiology among vertebrates, we tested the effects of three psychotropics (diazepam, doxapram, and nicotine) on Microsternarchus cf. bilineatus, measuring 10 parameters associated to the electric organ discharges rhythm and waveform before and after the administration of each drug and a control group. There were statistically significant differences (p < 0.005) among all the experimental groups, F (70, 22619.25) = 77.7, between the two experimental phases within their respective drug treatment, F (80, 24604.51) = 16.0, and among the six experimental hours within their respective phases and groups, F (320, 37124.15) = 4.1. We observed a common general trend of reduction in the electric organ's (EO) firing rate, regardless of the expected stimulant or depressor effect of the drugs on the central nervous system (CNS). The intensity of the response changed with the treatment. The observed changes in the fishes' behavior may be a result of the drugs' direct action on the CNS or a combination of this with systemic effects of each substance tested, also in the EO. © Copyright 2017, Mary Ann Liebert, Inc. 2017. |
| format |
Artigo |
| author |
Jesus, Isac Silva de |
| author2 |
Ferreira, Milena Silva-Júnior, Urbano Lopes Alves-Gomes, José Antônio |
| author2Str |
Ferreira, Milena Silva-Júnior, Urbano Lopes Alves-Gomes, José Antônio |
| title |
Effects of neuroactive drugs in the discharge patterns of microsternarchus (hypopomidae: gymnotiformes) electric organ |
| title_short |
Effects of neuroactive drugs in the discharge patterns of microsternarchus (hypopomidae: gymnotiformes) electric organ |
| title_full |
Effects of neuroactive drugs in the discharge patterns of microsternarchus (hypopomidae: gymnotiformes) electric organ |
| title_fullStr |
Effects of neuroactive drugs in the discharge patterns of microsternarchus (hypopomidae: gymnotiformes) electric organ |
| title_full_unstemmed |
Effects of neuroactive drugs in the discharge patterns of microsternarchus (hypopomidae: gymnotiformes) electric organ |
| title_sort |
effects of neuroactive drugs in the discharge patterns of microsternarchus (hypopomidae: gymnotiformes) electric organ |
| publisher |
Zebrafish |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/17003 |
| _version_ |
1787141065919168512 |
| score |
11.755432 |