Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes
Aniba canelilla (H.B.K.) Mez, popularly known as “casca-preciosa” (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The present...
| Autor principal: | Giongo, Janice Luehring |
|---|---|
| Outros Autores: | Vaucher, Rodrigo de Almeida, Silva, Aleksandro Schafer da, Oliveira, Camila Belmonte, Mattos, Cristiane Bastos de, Baldissera, Matheus Dellaméa, Sagrillo, Michele Rorato, Monteiro, Sílvia González, Custódio, Dayana Lacerda, Souza de Matos, Marcielly, Sampaio, Paulo de Tarso Barbosa, Teixeira, Helder Ferreira, Koester, Letícia Scherer, Veiga-Junior, Valdir F. |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Microbial Pathogenesis
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/17172 |
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oai:repositorio:1-17172 |
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oai:repositorio:1-17172 Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes Giongo, Janice Luehring Vaucher, Rodrigo de Almeida Silva, Aleksandro Schafer da Oliveira, Camila Belmonte Mattos, Cristiane Bastos de Baldissera, Matheus Dellaméa Sagrillo, Michele Rorato Monteiro, Sílvia González Custódio, Dayana Lacerda Souza de Matos, Marcielly Sampaio, Paulo de Tarso Barbosa Teixeira, Helder Ferreira Koester, Letícia Scherer Veiga-Junior, Valdir F. 1-nitro-2-phenylethane Aniba Canelilla Extract Antitrypanosomal Agent Benzene Acetonitrile Diminazene Aceturate Essential Oil Linalool Methyleugenol Neointermedeol Plant Extract Unclassified Drug Antitrypanosomal Agent Essential Oil Plant Extract Vegetable Oil Aniba Canelilla Cell Viability Controlled Study Cytotoxicity Drug Activity Drug Isolation Drug Screening Drug Structure Human Human Cell In Vitro Study Lauraceae Lymphocyte Mass Fragmentography Nonhuman Plant Stem Priority Journal Trypanocidal Activity Trypanosoma Evansi Trypanosomiasis Cell Survival Chemistry Drug Effects Embryophyta Gas Chromatography Lymphocyte Trypanosoma Cell Survival Gas Chromatography Embryophyta Humans Lymphocytes Oils, Volatile Plant Extracts Plant Oils Trypanocidal Agents Trypanosoma Aniba canelilla (H.B.K.) Mez, popularly known as “casca-preciosa” (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The present study aimed to report the chemical characterization of the oil extracted from Aniba canelilla using gas-chromatography/mass spectrometry and to assess its in vitro trypanocidal activity against Trypanosoma evansi, a prevalent haemoflagellate parasite that affects a broad range of mammal species in Africa, Asia and South America. The oil presented 1-nitro-2-phenylethane (83.68%) and methyleugenol (14.83%) as the two major components. The essential oil as well as both major compounds were shown to exert trypanocidal effect. Methyleugenol was slightly more active than 1-nitro-2-phenylethane. In vitro studies showed that the oil extracted from the stems of A. canelilla may be regarded as a potential natural treatment for trypanosomosis, once proven their in vivo action, may be an interesting alternative in the treatment of infected animals with T. evansi. © 2016 Elsevier Ltd 2020-06-15T21:39:38Z 2020-06-15T21:39:38Z 2017 Artigo https://repositorio.inpa.gov.br/handle/1/17172 10.1016/j.micpath.2016.12.006 en Volume 103, Pags. 13-18 Restrito Microbial Pathogenesis |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
1-nitro-2-phenylethane Aniba Canelilla Extract Antitrypanosomal Agent Benzene Acetonitrile Diminazene Aceturate Essential Oil Linalool Methyleugenol Neointermedeol Plant Extract Unclassified Drug Antitrypanosomal Agent Essential Oil Plant Extract Vegetable Oil Aniba Canelilla Cell Viability Controlled Study Cytotoxicity Drug Activity Drug Isolation Drug Screening Drug Structure Human Human Cell In Vitro Study Lauraceae Lymphocyte Mass Fragmentography Nonhuman Plant Stem Priority Journal Trypanocidal Activity Trypanosoma Evansi Trypanosomiasis Cell Survival Chemistry Drug Effects Embryophyta Gas Chromatography Lymphocyte Trypanosoma Cell Survival Gas Chromatography Embryophyta Humans Lymphocytes Oils, Volatile Plant Extracts Plant Oils Trypanocidal Agents Trypanosoma |
| spellingShingle |
1-nitro-2-phenylethane Aniba Canelilla Extract Antitrypanosomal Agent Benzene Acetonitrile Diminazene Aceturate Essential Oil Linalool Methyleugenol Neointermedeol Plant Extract Unclassified Drug Antitrypanosomal Agent Essential Oil Plant Extract Vegetable Oil Aniba Canelilla Cell Viability Controlled Study Cytotoxicity Drug Activity Drug Isolation Drug Screening Drug Structure Human Human Cell In Vitro Study Lauraceae Lymphocyte Mass Fragmentography Nonhuman Plant Stem Priority Journal Trypanocidal Activity Trypanosoma Evansi Trypanosomiasis Cell Survival Chemistry Drug Effects Embryophyta Gas Chromatography Lymphocyte Trypanosoma Cell Survival Gas Chromatography Embryophyta Humans Lymphocytes Oils, Volatile Plant Extracts Plant Oils Trypanocidal Agents Trypanosoma Giongo, Janice Luehring Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes |
| topic_facet |
1-nitro-2-phenylethane Aniba Canelilla Extract Antitrypanosomal Agent Benzene Acetonitrile Diminazene Aceturate Essential Oil Linalool Methyleugenol Neointermedeol Plant Extract Unclassified Drug Antitrypanosomal Agent Essential Oil Plant Extract Vegetable Oil Aniba Canelilla Cell Viability Controlled Study Cytotoxicity Drug Activity Drug Isolation Drug Screening Drug Structure Human Human Cell In Vitro Study Lauraceae Lymphocyte Mass Fragmentography Nonhuman Plant Stem Priority Journal Trypanocidal Activity Trypanosoma Evansi Trypanosomiasis Cell Survival Chemistry Drug Effects Embryophyta Gas Chromatography Lymphocyte Trypanosoma Cell Survival Gas Chromatography Embryophyta Humans Lymphocytes Oils, Volatile Plant Extracts Plant Oils Trypanocidal Agents Trypanosoma |
| description |
Aniba canelilla (H.B.K.) Mez, popularly known as “casca-preciosa” (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The present study aimed to report the chemical characterization of the oil extracted from Aniba canelilla using gas-chromatography/mass spectrometry and to assess its in vitro trypanocidal activity against Trypanosoma evansi, a prevalent haemoflagellate parasite that affects a broad range of mammal species in Africa, Asia and South America. The oil presented 1-nitro-2-phenylethane (83.68%) and methyleugenol (14.83%) as the two major components. The essential oil as well as both major compounds were shown to exert trypanocidal effect. Methyleugenol was slightly more active than 1-nitro-2-phenylethane. In vitro studies showed that the oil extracted from the stems of A. canelilla may be regarded as a potential natural treatment for trypanosomosis, once proven their in vivo action, may be an interesting alternative in the treatment of infected animals with T. evansi. © 2016 Elsevier Ltd |
| format |
Artigo |
| author |
Giongo, Janice Luehring |
| author2 |
Vaucher, Rodrigo de Almeida Silva, Aleksandro Schafer da Oliveira, Camila Belmonte Mattos, Cristiane Bastos de Baldissera, Matheus Dellaméa Sagrillo, Michele Rorato Monteiro, Sílvia González Custódio, Dayana Lacerda Souza de Matos, Marcielly Sampaio, Paulo de Tarso Barbosa Teixeira, Helder Ferreira Koester, Letícia Scherer Veiga-Junior, Valdir F. |
| author2Str |
Vaucher, Rodrigo de Almeida Silva, Aleksandro Schafer da Oliveira, Camila Belmonte Mattos, Cristiane Bastos de Baldissera, Matheus Dellaméa Sagrillo, Michele Rorato Monteiro, Sílvia González Custódio, Dayana Lacerda Souza de Matos, Marcielly Sampaio, Paulo de Tarso Barbosa Teixeira, Helder Ferreira Koester, Letícia Scherer Veiga-Junior, Valdir F. |
| title |
Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes |
| title_short |
Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes |
| title_full |
Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes |
| title_fullStr |
Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes |
| title_full_unstemmed |
Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes |
| title_sort |
trypanocidal activity of the compounds present in aniba canelilla oil against trypanosoma evansi and its effects on viability of lymphocytes |
| publisher |
Microbial Pathogenesis |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/17172 |
| _version_ |
1787141483100372992 |
| score |
11.755432 |