Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil

Silva, George Allan Villarouco da; Ramasawmy, Rajendranath; Boechat, Antonio Luiz; Morais, A. C.; Carvalho, B. K.S.; Sousa, K. B A; Souza, V. C.; Cunha, Maria Coelho Graça Souza; Barletta-Naveca, Raphaela Honorato; Santos, M. P.; Naveca, Felipe Gomes

Artigo

Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil

Polymorphisms present in the TNF promoter region has shown to influence the gene transcription. Leprosy displays different clinical manifestations according to the immune responses of the individual infected with Mycobacterium leprae. In this study, we evaluated the single nucleotide polymorphisms (...

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Autor principal:	Silva, George Allan Villarouco da
Outros Autores:	Ramasawmy, Rajendranath, Boechat, Antonio Luiz, Morais, A. C., Carvalho, B. K.S., Sousa, K. B A, Souza, V. C., Cunha, Maria Coelho Graça Souza, Barletta-Naveca, Raphaela Honorato, Santos, M. P., Naveca, Felipe Gomes
Grau:	Artigo
Idioma:	English
Publicado em:	Human Immunology 2020
Assuntos:	Dna Nucleotide Tumor Necrosis Factor Biological Marker Tumor Necrosis Factor-alpha Amazona Brasil Controlled Study Female Gene Frequency Genetic Association Genotype Host Susceptibility Human Leprosy Major Clinical Study Male Outcome Assessment Priority Journal Promoter Region Polymorphism, Single Nucleotide Disease Course Genetic Association Genetic Predisposition Genetics Genotype Immunology Leprosy Metabolism Mycobacterium Leprae Nucleotide Sequence Predictive Value Promoter Region Biomarkers Brasil Disease Progression Dna Mutational Analysis Gene Frequency Genetic Association Studies Genetic Predisposition To Disease Genotype Humans Leprosy Mycobacterium Leprae Polymorphism, Single Nucleotide Predictive Value Of Tests Promoter Regions, Genetic Tumor Necrosis Factor-alpha
Acesso em linha:	https://repositorio.inpa.gov.br/handle/1/17493

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spelling	oai:repositorio:1-17493 Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil Silva, George Allan Villarouco da Ramasawmy, Rajendranath Boechat, Antonio Luiz Morais, A. C. Carvalho, B. K.S. Sousa, K. B A Souza, V. C. Cunha, Maria Coelho Graça Souza Barletta-Naveca, Raphaela Honorato Santos, M. P. Naveca, Felipe Gomes Dna Nucleotide Tumor Necrosis Factor Biological Marker Tumor Necrosis Factor-alpha Amazona Brasil Controlled Study Female Gene Frequency Genetic Association Genotype Host Susceptibility Human Leprosy Major Clinical Study Male Outcome Assessment Priority Journal Promoter Region Polymorphism, Single Nucleotide Disease Course Genetic Association Genetic Predisposition Genetics Genotype Immunology Leprosy Metabolism Mycobacterium Leprae Nucleotide Sequence Predictive Value Promoter Region Biomarkers Brasil Disease Progression Dna Mutational Analysis Gene Frequency Genetic Association Studies Genetic Predisposition To Disease Genotype Humans Leprosy Mycobacterium Leprae Polymorphism, Single Nucleotide Predictive Value Of Tests Promoter Regions, Genetic Tumor Necrosis Factor-alpha Polymorphisms present in the TNF promoter region has shown to influence the gene transcription. Leprosy displays different clinical manifestations according to the immune responses of the individual infected with Mycobacterium leprae. In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs361525), -308 G/A (rs1800629), -857 C/T (rs1799724), -863 A/C (rs1800630) and -1031 T/C (rs1799964) in the promoter region of the TNF to see whether these SNPs influence host-susceptibility to leprosy and the different clinical manifestation. Nucleotide sequencing was performed with DNA samples from 108 leprosy patients and 253 control subjects. An association between -1031 C/C genotype and protection from leprosy was observed when leprosy patients were compared to controls (OR 0.11; 95% CI. =. 0.01-0.82; p=. 0.012). The -857 C/T genotype may be associated with susceptibility to leprosy (OR. =. 1.81; 95% CI. =. 1.09-3.00; p=. 0.028). Similar genotype and allele frequencies for the SNPs -308 G/A and -238 G/A were observed between leprosy patients and control subjects. Altogether, TNF polymorphisms in the promoter region may be predictive of leprosy outcome. © 2015 American Society for Histocompatibility and Immunogenetics. 2020-06-15T21:48:05Z 2020-06-15T21:48:05Z 2015 Artigo https://repositorio.inpa.gov.br/handle/1/17493 10.1016/j.humimm.2015.01.011 en Volume 76, Número 2-3, Pags. 137-141 Restrito Human Immunology
institution	Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional
collection	INPA-RI
language	English
topic	Dna Nucleotide Tumor Necrosis Factor Biological Marker Tumor Necrosis Factor-alpha Amazona Brasil Controlled Study Female Gene Frequency Genetic Association Genotype Host Susceptibility Human Leprosy Major Clinical Study Male Outcome Assessment Priority Journal Promoter Region Polymorphism, Single Nucleotide Disease Course Genetic Association Genetic Predisposition Genetics Genotype Immunology Leprosy Metabolism Mycobacterium Leprae Nucleotide Sequence Predictive Value Promoter Region Biomarkers Brasil Disease Progression Dna Mutational Analysis Gene Frequency Genetic Association Studies Genetic Predisposition To Disease Genotype Humans Leprosy Mycobacterium Leprae Polymorphism, Single Nucleotide Predictive Value Of Tests Promoter Regions, Genetic Tumor Necrosis Factor-alpha
spellingShingle	Dna Nucleotide Tumor Necrosis Factor Biological Marker Tumor Necrosis Factor-alpha Amazona Brasil Controlled Study Female Gene Frequency Genetic Association Genotype Host Susceptibility Human Leprosy Major Clinical Study Male Outcome Assessment Priority Journal Promoter Region Polymorphism, Single Nucleotide Disease Course Genetic Association Genetic Predisposition Genetics Genotype Immunology Leprosy Metabolism Mycobacterium Leprae Nucleotide Sequence Predictive Value Promoter Region Biomarkers Brasil Disease Progression Dna Mutational Analysis Gene Frequency Genetic Association Studies Genetic Predisposition To Disease Genotype Humans Leprosy Mycobacterium Leprae Polymorphism, Single Nucleotide Predictive Value Of Tests Promoter Regions, Genetic Tumor Necrosis Factor-alpha Silva, George Allan Villarouco da Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil
topic_facet	Dna Nucleotide Tumor Necrosis Factor Biological Marker Tumor Necrosis Factor-alpha Amazona Brasil Controlled Study Female Gene Frequency Genetic Association Genotype Host Susceptibility Human Leprosy Major Clinical Study Male Outcome Assessment Priority Journal Promoter Region Polymorphism, Single Nucleotide Disease Course Genetic Association Genetic Predisposition Genetics Genotype Immunology Leprosy Metabolism Mycobacterium Leprae Nucleotide Sequence Predictive Value Promoter Region Biomarkers Brasil Disease Progression Dna Mutational Analysis Gene Frequency Genetic Association Studies Genetic Predisposition To Disease Genotype Humans Leprosy Mycobacterium Leprae Polymorphism, Single Nucleotide Predictive Value Of Tests Promoter Regions, Genetic Tumor Necrosis Factor-alpha
description	Polymorphisms present in the TNF promoter region has shown to influence the gene transcription. Leprosy displays different clinical manifestations according to the immune responses of the individual infected with Mycobacterium leprae. In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs361525), -308 G/A (rs1800629), -857 C/T (rs1799724), -863 A/C (rs1800630) and -1031 T/C (rs1799964) in the promoter region of the TNF to see whether these SNPs influence host-susceptibility to leprosy and the different clinical manifestation. Nucleotide sequencing was performed with DNA samples from 108 leprosy patients and 253 control subjects. An association between -1031 C/C genotype and protection from leprosy was observed when leprosy patients were compared to controls (OR 0.11; 95% CI. =. 0.01-0.82; p=. 0.012). The -857 C/T genotype may be associated with susceptibility to leprosy (OR. =. 1.81; 95% CI. =. 1.09-3.00; p=. 0.028). Similar genotype and allele frequencies for the SNPs -308 G/A and -238 G/A were observed between leprosy patients and control subjects. Altogether, TNF polymorphisms in the promoter region may be predictive of leprosy outcome. © 2015 American Society for Histocompatibility and Immunogenetics.
format	Artigo
author	Silva, George Allan Villarouco da
author2	Ramasawmy, Rajendranath Boechat, Antonio Luiz Morais, A. C. Carvalho, B. K.S. Sousa, K. B A Souza, V. C. Cunha, Maria Coelho Graça Souza Barletta-Naveca, Raphaela Honorato Santos, M. P. Naveca, Felipe Gomes
author2Str	Ramasawmy, Rajendranath Boechat, Antonio Luiz Morais, A. C. Carvalho, B. K.S. Sousa, K. B A Souza, V. C. Cunha, Maria Coelho Graça Souza Barletta-Naveca, Raphaela Honorato Santos, M. P. Naveca, Felipe Gomes
title	Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil
title_short	Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil
title_full	Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil
title_fullStr	Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil
title_full_unstemmed	Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil
title_sort	association of tnf -1031 c/c as a potential protection marker for leprosy development in amazonas state patients, brazil
publisher	Human Immunology
publishDate	2020
url	https://repositorio.inpa.gov.br/handle/1/17493
_version_	1787141145513426944
score	11.675088

Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil

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