Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients
We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C. Serum IL-6, TNF-α, IL-2, IFN-γ, IL-4, IL-10, and IL-17A levels were measured in 67 HCV patients (68.2% genotype 1 [G1]) and 4...
| Autor principal: | Tarragô, Andréa Monteiro |
|---|---|
| Outros Autores: | Costa, Allyson Guimarães da, Pimentel, João Paulo Diniz, Gomes, Samara Tatielle Monteiro, Freitas, Felipe Bonfim, Lalwani, Pritesh, Araújo, Ana Ruth Silva de, Silva Victória, Flamir da, Victória, Marilú Barbieri, Vallinoto, Antônio Carlos Rosário, Sadahiro, Aya, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Malheiro, Adriana |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Human Immunology
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/17759 |
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oai:repositorio:1-17759 |
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oai:repositorio:1-17759 Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients Tarragô, Andréa Monteiro Costa, Allyson Guimarães da Pimentel, João Paulo Diniz Gomes, Samara Tatielle Monteiro Freitas, Felipe Bonfim Lalwani, Pritesh Araújo, Ana Ruth Silva de Silva Victória, Flamir da Victória, Marilú Barbieri Vallinoto, Antônio Carlos Rosário Sadahiro, Aya Teixeira-Carvalho, Andréa Martins-Filho, Olindo Assis Malheiro, Adriana Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Gamma Interferon Il10 Protein, Human Il17a Protein, Human Il4 Protein, Human Il6 Protein, Human Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Blood Donor Brazilian Controlled Study Disease Course Dna Polymorphism Female Flow Cytometry Genetic Association Genotype Hepatitis C Hepatitis C Virus Genotype 1 Human Immunogenetics Major Clinical Study Male Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Adult Blood Case Control Study Hepatitis C, Chronic Polymorphism, Genetic Genetics Growth, Development And Aging Hepacivirus Host-pathogen Interaction Virology Adult Case-control Studies Female Genotype Hepacivirus Hepatitis C, Chronic Host-pathogen Interactions Humans Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Male Polymorphism, Genetic Tumor Necrosis Factor-alpha We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C. Serum IL-6, TNF-α, IL-2, IFN-γ, IL-4, IL-10, and IL-17A levels were measured in 67 HCV patients (68.2% genotype 1 [G1]) and 47 healthy controls. The HCV patients had higher IL-6, IL-2, IFN-γ, IL-10, and IL-17A levels than the controls. HCV G1 patients had higher IL-2 and IFN-γ levels than G2 patients. The -174IL6G>. C, -308TNFαG>. A, and -1082IL10A>. G variants were similarly distributed in both groups. However, HCV patients with the -174IL6GC variant had higher IL-2 and IFN-γ levels than patients with the GG and CC variants. Additionally, HCV patients with the -308TNFαGG genotype had higher IL-17A levels than patients with the AG genotype, whereas patients with the -1082IL10GG variant had higher IL-6 levels than patients with the AA and AG variants. A significant proportion of HCV patients had high levels of both IL-2 and IFN-γ. The subgroup of HCV patients with the G1/IL6CG/TNFαGG association displayed the highest proportions of high producers of IL-2 and IFN-γ whereas the subgroup with the G1/TNFαGG profile showed high proportions of high producers of IL-6 and IL-17A. HCV patients with other HCV/cytokine genotype associations showed no particular cytokine profile. Our results suggest that HCV genotype G1 and IL-6 and TNF-α polymorphisms have a clinically relevant influence on serum pro-inflammatory cytokine profile (IL-2 and IFN-γ) in HCV patients. © 2014 American Society for Histocompatibility and Immunogenetics. 2020-06-15T21:49:08Z 2020-06-15T21:49:08Z 2014 Artigo https://repositorio.inpa.gov.br/handle/1/17759 10.1016/j.humimm.2014.08.198 en Volume 75, Número 11, Pags. 1075-1083 Restrito Human Immunology |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Gamma Interferon Il10 Protein, Human Il17a Protein, Human Il4 Protein, Human Il6 Protein, Human Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Blood Donor Brazilian Controlled Study Disease Course Dna Polymorphism Female Flow Cytometry Genetic Association Genotype Hepatitis C Hepatitis C Virus Genotype 1 Human Immunogenetics Major Clinical Study Male Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Adult Blood Case Control Study Hepatitis C, Chronic Polymorphism, Genetic Genetics Growth, Development And Aging Hepacivirus Host-pathogen Interaction Virology Adult Case-control Studies Female Genotype Hepacivirus Hepatitis C, Chronic Host-pathogen Interactions Humans Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Male Polymorphism, Genetic Tumor Necrosis Factor-alpha |
| spellingShingle |
Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Gamma Interferon Il10 Protein, Human Il17a Protein, Human Il4 Protein, Human Il6 Protein, Human Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Blood Donor Brazilian Controlled Study Disease Course Dna Polymorphism Female Flow Cytometry Genetic Association Genotype Hepatitis C Hepatitis C Virus Genotype 1 Human Immunogenetics Major Clinical Study Male Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Adult Blood Case Control Study Hepatitis C, Chronic Polymorphism, Genetic Genetics Growth, Development And Aging Hepacivirus Host-pathogen Interaction Virology Adult Case-control Studies Female Genotype Hepacivirus Hepatitis C, Chronic Host-pathogen Interactions Humans Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Male Polymorphism, Genetic Tumor Necrosis Factor-alpha Tarragô, Andréa Monteiro Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients |
| topic_facet |
Cytokine Gamma Interferon Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Gamma Interferon Il10 Protein, Human Il17a Protein, Human Il4 Protein, Human Il6 Protein, Human Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Tumor Necrosis Factor-alpha Blood Donor Brazilian Controlled Study Disease Course Dna Polymorphism Female Flow Cytometry Genetic Association Genotype Hepatitis C Hepatitis C Virus Genotype 1 Human Immunogenetics Major Clinical Study Male Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Adult Blood Case Control Study Hepatitis C, Chronic Polymorphism, Genetic Genetics Growth, Development And Aging Hepacivirus Host-pathogen Interaction Virology Adult Case-control Studies Female Genotype Hepacivirus Hepatitis C, Chronic Host-pathogen Interactions Humans Interferon-gamma Interleukin-10 Interleukin-17 Interleukin-2 Interleukin-4 Interleukin-6 Male Polymorphism, Genetic Tumor Necrosis Factor-alpha |
| description |
We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C. Serum IL-6, TNF-α, IL-2, IFN-γ, IL-4, IL-10, and IL-17A levels were measured in 67 HCV patients (68.2% genotype 1 [G1]) and 47 healthy controls. The HCV patients had higher IL-6, IL-2, IFN-γ, IL-10, and IL-17A levels than the controls. HCV G1 patients had higher IL-2 and IFN-γ levels than G2 patients. The -174IL6G>. C, -308TNFαG>. A, and -1082IL10A>. G variants were similarly distributed in both groups. However, HCV patients with the -174IL6GC variant had higher IL-2 and IFN-γ levels than patients with the GG and CC variants. Additionally, HCV patients with the -308TNFαGG genotype had higher IL-17A levels than patients with the AG genotype, whereas patients with the -1082IL10GG variant had higher IL-6 levels than patients with the AA and AG variants. A significant proportion of HCV patients had high levels of both IL-2 and IFN-γ. The subgroup of HCV patients with the G1/IL6CG/TNFαGG association displayed the highest proportions of high producers of IL-2 and IFN-γ whereas the subgroup with the G1/TNFαGG profile showed high proportions of high producers of IL-6 and IL-17A. HCV patients with other HCV/cytokine genotype associations showed no particular cytokine profile. Our results suggest that HCV genotype G1 and IL-6 and TNF-α polymorphisms have a clinically relevant influence on serum pro-inflammatory cytokine profile (IL-2 and IFN-γ) in HCV patients. © 2014 American Society for Histocompatibility and Immunogenetics. |
| format |
Artigo |
| author |
Tarragô, Andréa Monteiro |
| author2 |
Costa, Allyson Guimarães da Pimentel, João Paulo Diniz Gomes, Samara Tatielle Monteiro Freitas, Felipe Bonfim Lalwani, Pritesh Araújo, Ana Ruth Silva de Silva Victória, Flamir da Victória, Marilú Barbieri Vallinoto, Antônio Carlos Rosário Sadahiro, Aya Teixeira-Carvalho, Andréa Martins-Filho, Olindo Assis Malheiro, Adriana |
| author2Str |
Costa, Allyson Guimarães da Pimentel, João Paulo Diniz Gomes, Samara Tatielle Monteiro Freitas, Felipe Bonfim Lalwani, Pritesh Araújo, Ana Ruth Silva de Silva Victória, Flamir da Victória, Marilú Barbieri Vallinoto, Antônio Carlos Rosário Sadahiro, Aya Teixeira-Carvalho, Andréa Martins-Filho, Olindo Assis Malheiro, Adriana |
| title |
Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients |
| title_short |
Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients |
| title_full |
Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients |
| title_fullStr |
Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients |
| title_full_unstemmed |
Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients |
| title_sort |
combined impact of hepatitis c virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in brazilian hcv-infected patients |
| publisher |
Human Immunology |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/17759 |
| _version_ |
1787141488824549376 |
| score |
11.755432 |