Isolation and identification of α-glucosidase, α-amylase and lipase inhibitors from Hortia longifolia
Phytochemical investigation from branches of Hortia longifolia (Rutaceae) yielded the amide N-[2-(4-prenyloxyphenyl)ethyl]tigliamide (1), (E)-methyl-O-prenyl ferulate (2), limonin (3), cinnamic acid derivatives [(E)-methyl-5'-hydroxy-O-prenyl cinnamate 4 and integrifoliodiol 7], scopoletin (5) and s...
| Autor principal: | Queiroz, Darlene P.K. |
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| Outros Autores: | Ferreira, Antonio Gilberto, Lima, Arleilson Sousa, Lima, Emerson Silva, Lima, Maria da Paz |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
International Journal of Pharmacy and Pharmaceutical Sciences
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/17843 |
| Resumo: |
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Phytochemical investigation from branches of Hortia longifolia (Rutaceae) yielded the amide N-[2-(4-prenyloxyphenyl)ethyl]tigliamide (1), (E)-methyl-O-prenyl ferulate (2), limonin (3), cinnamic acid derivatives [(E)-methyl-5'-hydroxy-O-prenyl cinnamate 4 and integrifoliodiol 7], scopoletin (5) and skimmianine (6). The compound 4 showed moderate α-amylase inhibitory activity, the coumarin 5 presented strong activity on α-glucosidase (IC50 of 0.89 μg/mL). The compounds 1, 2, 4 and 5 exhibited significant inhibitory activity on lipase with IC50 at 6.91, 8.14, 3.86 and 5.07 μg/mL, respectively. The results demonstrate potential use for these compounds in development of drugs of natural origin in the prevention or treatment of metabolic syndrome. |