The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II
Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen "Neg...
| Autor principal: | Schmidt, Thomas Jürgen |
|---|---|
| Outros Autores: | Khalid, Sami A., Romanha, Álvaro José, Alves, Tânia Maria de Almeida, Biavatti, Maique Weber, Brun, Reto, Costa, Fernando Batista da, De-Castro, Solange Lisboa, Ferreira, V?tor Francisco, Lacerda, Marcus Vinícius Guimarães de, Lago, João Henriqu Ghilardi, Leon, Leonor Laura Pinto, Lopes, Norberto Peporine, Amorim, Rodrigo César das Neves, Niehues, Michael, Ogungbe, Ifedayo Victor, Pohlit, Adrian Martin, Scotti, M. T., Setzer, William N., Soeiro, M. N.C. de, Steindel, Mário R., Tempone, Andre Gustavo |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Current Medicinal Chemistry
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/18054 |
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oai:repositorio:1-18054 The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II Schmidt, Thomas Jürgen Khalid, Sami A. Romanha, Álvaro José Alves, Tânia Maria de Almeida Biavatti, Maique Weber Brun, Reto Costa, Fernando Batista da De-Castro, Solange Lisboa Ferreira, V?tor Francisco Lacerda, Marcus Vinícius Guimarães de Lago, João Henriqu Ghilardi Leon, Leonor Laura Pinto Lopes, Norberto Peporine Amorim, Rodrigo César das Neves Niehues, Michael Ogungbe, Ifedayo Victor Pohlit, Adrian Martin Scotti, M. T. Setzer, William N. Soeiro, M. N.C. de Steindel, Mário R. Tempone, Andre Gustavo Acridone Derivative Alizarin Aloe Emodin Antileishmanial Agent Beta Lapachone Caffeic Acid Derivative Coumarin Diospyrin Diprophylline Emodin Galgravin Juglone Kaempferol Lapachol Lawsone Lignan Luteolin Neolignan Nordihydroguaiaretic Acid Phytomenadione Plant Extract Plastoquinone Plumbagin Purpurin Scopoletin Stibogluconate Sodium Thamnosma Rhodesica Toddalia Asiatica Extract Ubiquinone Unclassified Drug Unindexed Drug African Trypanosomiasis Antiprotozoal Activity Aristolochiaceae Calophyllaceae Chagas Disease Clausena Epimastigote Human In Vitro Study Leishmaniasis Medicinal Plant Nonhuman Rutaceae Tropical Disease Trypomastigote Animal Antiprotozoal Agents Biological Agents Humans Neglected Diseases Phytotherapy Plant Extracts Plants, Medicinal Protozoan Infections Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen "Neglected Tropical Diseases" (NTDs) defined by the WHO. Furthermore, malaria (caused by various Plasmodium species) can be considered a neglected disease in certain countries and with regard to availability and affordability of the antimalarials. Living organisms, especially plants, provide an innumerable number of molecules with potential for the treatment of many serious diseases. The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs. In part I, a general description of the diseases, the current state of therapy and need for new therapeuticals, assay methods and strategies applied in the search for new plant derived natural products against these diseases and an overview on natural products of terpenoid origin with antiprotozoal potential were given. The present part II compiles the current knowledge on natural products with antiprotozoal activity that are derived from the shikimate pathway (lignans, coumarins, caffeic acid derivatives), quinones of various structural classes, compounds formed via the polyketide pathways (flavonoids and related compounds, chromenes and related benzopyrans and benzofurans, xanthones, acetogenins from Annonaceae and polyacetylenes) as well as the diverse classes of alkaloids. In total, both parts compile the literature on almost 900 different plant-derived natural products and their activity data, taken from over 800 references. These data, as the result of enormous efforts of numerous research groups world-wide, illustrate that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs. Only a small percentage, however, of the roughly 200,000 plant species on earth have been studied chemically and only a small percentage of these plants or their constituents has been investigated for antiprotozoal activity. The repository of plant-derived natural products hence deserves to be investigated even more intensely than it has been up to present. © 2012 Bentham Science Publishers. 2020-06-15T21:51:15Z 2020-06-15T21:51:15Z 2012 Artigo https://repositorio.inpa.gov.br/handle/1/18054 en Volume 19, Número 14, Pags. 2176-2228 Restrito Current Medicinal Chemistry |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Acridone Derivative Alizarin Aloe Emodin Antileishmanial Agent Beta Lapachone Caffeic Acid Derivative Coumarin Diospyrin Diprophylline Emodin Galgravin Juglone Kaempferol Lapachol Lawsone Lignan Luteolin Neolignan Nordihydroguaiaretic Acid Phytomenadione Plant Extract Plastoquinone Plumbagin Purpurin Scopoletin Stibogluconate Sodium Thamnosma Rhodesica Toddalia Asiatica Extract Ubiquinone Unclassified Drug Unindexed Drug African Trypanosomiasis Antiprotozoal Activity Aristolochiaceae Calophyllaceae Chagas Disease Clausena Epimastigote Human In Vitro Study Leishmaniasis Medicinal Plant Nonhuman Rutaceae Tropical Disease Trypomastigote Animal Antiprotozoal Agents Biological Agents Humans Neglected Diseases Phytotherapy Plant Extracts Plants, Medicinal Protozoan Infections |
| spellingShingle |
Acridone Derivative Alizarin Aloe Emodin Antileishmanial Agent Beta Lapachone Caffeic Acid Derivative Coumarin Diospyrin Diprophylline Emodin Galgravin Juglone Kaempferol Lapachol Lawsone Lignan Luteolin Neolignan Nordihydroguaiaretic Acid Phytomenadione Plant Extract Plastoquinone Plumbagin Purpurin Scopoletin Stibogluconate Sodium Thamnosma Rhodesica Toddalia Asiatica Extract Ubiquinone Unclassified Drug Unindexed Drug African Trypanosomiasis Antiprotozoal Activity Aristolochiaceae Calophyllaceae Chagas Disease Clausena Epimastigote Human In Vitro Study Leishmaniasis Medicinal Plant Nonhuman Rutaceae Tropical Disease Trypomastigote Animal Antiprotozoal Agents Biological Agents Humans Neglected Diseases Phytotherapy Plant Extracts Plants, Medicinal Protozoan Infections Schmidt, Thomas Jürgen The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II |
| topic_facet |
Acridone Derivative Alizarin Aloe Emodin Antileishmanial Agent Beta Lapachone Caffeic Acid Derivative Coumarin Diospyrin Diprophylline Emodin Galgravin Juglone Kaempferol Lapachol Lawsone Lignan Luteolin Neolignan Nordihydroguaiaretic Acid Phytomenadione Plant Extract Plastoquinone Plumbagin Purpurin Scopoletin Stibogluconate Sodium Thamnosma Rhodesica Toddalia Asiatica Extract Ubiquinone Unclassified Drug Unindexed Drug African Trypanosomiasis Antiprotozoal Activity Aristolochiaceae Calophyllaceae Chagas Disease Clausena Epimastigote Human In Vitro Study Leishmaniasis Medicinal Plant Nonhuman Rutaceae Tropical Disease Trypomastigote Animal Antiprotozoal Agents Biological Agents Humans Neglected Diseases Phytotherapy Plant Extracts Plants, Medicinal Protozoan Infections |
| description |
Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen "Neglected Tropical Diseases" (NTDs) defined by the WHO. Furthermore, malaria (caused by various Plasmodium species) can be considered a neglected disease in certain countries and with regard to availability and affordability of the antimalarials. Living organisms, especially plants, provide an innumerable number of molecules with potential for the treatment of many serious diseases. The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs. In part I, a general description of the diseases, the current state of therapy and need for new therapeuticals, assay methods and strategies applied in the search for new plant derived natural products against these diseases and an overview on natural products of terpenoid origin with antiprotozoal potential were given. The present part II compiles the current knowledge on natural products with antiprotozoal activity that are derived from the shikimate pathway (lignans, coumarins, caffeic acid derivatives), quinones of various structural classes, compounds formed via the polyketide pathways (flavonoids and related compounds, chromenes and related benzopyrans and benzofurans, xanthones, acetogenins from Annonaceae and polyacetylenes) as well as the diverse classes of alkaloids. In total, both parts compile the literature on almost 900 different plant-derived natural products and their activity data, taken from over 800 references. These data, as the result of enormous efforts of numerous research groups world-wide, illustrate that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs. Only a small percentage, however, of the roughly 200,000 plant species on earth have been studied chemically and only a small percentage of these plants or their constituents has been investigated for antiprotozoal activity. The repository of plant-derived natural products hence deserves to be investigated even more intensely than it has been up to present. © 2012 Bentham Science Publishers. |
| format |
Artigo |
| author |
Schmidt, Thomas Jürgen |
| author2 |
Khalid, Sami A. Romanha, Álvaro José Alves, Tânia Maria de Almeida Biavatti, Maique Weber Brun, Reto Costa, Fernando Batista da De-Castro, Solange Lisboa Ferreira, V?tor Francisco Lacerda, Marcus Vinícius Guimarães de Lago, João Henriqu Ghilardi Leon, Leonor Laura Pinto Lopes, Norberto Peporine Amorim, Rodrigo César das Neves Niehues, Michael Ogungbe, Ifedayo Victor Pohlit, Adrian Martin Scotti, M. T. Setzer, William N. Soeiro, M. N.C. de Steindel, Mário R. Tempone, Andre Gustavo |
| author2Str |
Khalid, Sami A. Romanha, Álvaro José Alves, Tânia Maria de Almeida Biavatti, Maique Weber Brun, Reto Costa, Fernando Batista da De-Castro, Solange Lisboa Ferreira, V?tor Francisco Lacerda, Marcus Vinícius Guimarães de Lago, João Henriqu Ghilardi Leon, Leonor Laura Pinto Lopes, Norberto Peporine Amorim, Rodrigo César das Neves Niehues, Michael Ogungbe, Ifedayo Victor Pohlit, Adrian Martin Scotti, M. T. Setzer, William N. Soeiro, M. N.C. de Steindel, Mário R. Tempone, Andre Gustavo |
| title |
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II |
| title_short |
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II |
| title_full |
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II |
| title_fullStr |
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II |
| title_full_unstemmed |
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II |
| title_sort |
potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part ii |
| publisher |
Current Medicinal Chemistry |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/18054 |
| _version_ |
1787141934376026112 |
| score |
11.674684 |