Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission
In this study, we provide phylogenetic and biogeographic evidence that the Trypanosoma cruzi lineages T. cruzi I (TCI) and T. cruzi IIa (TCIIa) circulate amongst non-human primates in Brazilian Amazonia, and are transmitted by Rhodnius species in overlapping arboreal transmission cycles, sporadicall...
| Autor principal: | Marcili, Arlei |
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| Outros Autores: | Valente, Vera da Costa, Valente, Sebastiäo Aldo S., Junqueira, Ângela Cristina Veríssimo, Silva, Flávia Maia da, Pinto, Ana Yecê das Neves, Naiff, Roberto Daibes, Campaner, Marta, Coura, José Rodrigues, Camargo, Erney Plessmann, Miles, Michael Alexander, Teixeira, Marta Maria Geraldes |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
International Journal for Parasitology
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/18449 |
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oai:repositorio:1-18449 |
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oai:repositorio:1-18449 Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission Marcili, Arlei Valente, Vera da Costa Valente, Sebastiäo Aldo S. Junqueira, Ângela Cristina Veríssimo Silva, Flávia Maia da Pinto, Ana Yecê das Neves Naiff, Roberto Daibes Campaner, Marta Coura, José Rodrigues Camargo, Erney Plessmann Miles, Michael Alexander Teixeira, Marta Maria Geraldes Biogeography Chagas Disease Cytochrome Disease Transmission Dna Hominid Insect Pathology Phylogenetics Phylogeny Primate Protozoan Animal Aotidae Brasil Cebidae Chagas Disease Cytochromes B Dna, Protozoan Genotype Humans Insect Vectors Monkey Diseases Phylogeny Polymorphism, Genetic Primates Random Amplified Polymorphic Dna Technique Rhodnius Saguinus Species Specificity Trypanosoma Cruzi Amazonia South America Cytochrome B Protozoal Dna Animals Aotidae Brasil Cebidae Chagas Disease Classification Disease Carrier Polymorphism, Genetic Genetics Genotype Human Isolation And Purification Monkey Diseases Parasitology Phylogeny Primate Procedures Random Amplified Polymorphic Dna Rhodnius Saguinus Species Difference Transmission Trypanosoma Cruzi Veterinary Animal Aotidae Brasil Cebidae Chagas Disease Cytochromes B Dna, Protozoan Genotype Humans Insect Vectors Monkey Diseases Phylogeny Polymorphism, Genetic Primates Random Amplified Polymorphic Dna Technique Rhodnius Saguinus Species Specificity Trypanosoma Cruzi In this study, we provide phylogenetic and biogeographic evidence that the Trypanosoma cruzi lineages T. cruzi I (TCI) and T. cruzi IIa (TCIIa) circulate amongst non-human primates in Brazilian Amazonia, and are transmitted by Rhodnius species in overlapping arboreal transmission cycles, sporadically infecting humans. TCI presented higher prevalence rates, and no lineages other than TCI and TCIIa were found in this study in wild monkeys and Rhodnius from the Amazonian region. We characterised TCI and TCIIa from wild primates (16 TCI and five TCIIa), Rhodnius spp. (13 TCI and nine TCIIa), and humans with Chagas disease associated with oral transmission (14 TCI and five TCIIa) in Brazilian Amazonia. To our knowledge, TCIIa had not been associated with wild monkeys until now. Polymorphisms of ssrDNA, cytochrome b gene sequences and randomly amplified polymorphic DNA (RAPD) patterns clearly separated TCIIa from TCIIb-e and TCI lineages, and disclosed small intra-lineage polymorphisms amongst isolates from Amazonia. These data are important in understanding the complexity of the transmission cycles, genetic structure, and evolutionary history of T. cruzi populations circulating in Amazonia, and they contribute to both the unravelling of human infection routes and the pathological peculiarities of Chagas disease in this region. © 2008 Australian Society for Parasitology Inc. 2020-06-15T21:55:11Z 2020-06-15T21:55:11Z 2009 Artigo https://repositorio.inpa.gov.br/handle/1/18449 10.1016/j.ijpara.2008.09.015 en Volume 39, Número 5, Pags. 615-623 Restrito International Journal for Parasitology |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Biogeography Chagas Disease Cytochrome Disease Transmission Dna Hominid Insect Pathology Phylogenetics Phylogeny Primate Protozoan Animal Aotidae Brasil Cebidae Chagas Disease Cytochromes B Dna, Protozoan Genotype Humans Insect Vectors Monkey Diseases Phylogeny Polymorphism, Genetic Primates Random Amplified Polymorphic Dna Technique Rhodnius Saguinus Species Specificity Trypanosoma Cruzi Amazonia South America Cytochrome B Protozoal Dna Animals Aotidae Brasil Cebidae Chagas Disease Classification Disease Carrier Polymorphism, Genetic Genetics Genotype Human Isolation And Purification Monkey Diseases Parasitology Phylogeny Primate Procedures Random Amplified Polymorphic Dna Rhodnius Saguinus Species Difference Transmission Trypanosoma Cruzi Veterinary Animal Aotidae Brasil Cebidae Chagas Disease Cytochromes B Dna, Protozoan Genotype Humans Insect Vectors Monkey Diseases Phylogeny Polymorphism, Genetic Primates Random Amplified Polymorphic Dna Technique Rhodnius Saguinus Species Specificity Trypanosoma Cruzi |
| spellingShingle |
Biogeography Chagas Disease Cytochrome Disease Transmission Dna Hominid Insect Pathology Phylogenetics Phylogeny Primate Protozoan Animal Aotidae Brasil Cebidae Chagas Disease Cytochromes B Dna, Protozoan Genotype Humans Insect Vectors Monkey Diseases Phylogeny Polymorphism, Genetic Primates Random Amplified Polymorphic Dna Technique Rhodnius Saguinus Species Specificity Trypanosoma Cruzi Amazonia South America Cytochrome B Protozoal Dna Animals Aotidae Brasil Cebidae Chagas Disease Classification Disease Carrier Polymorphism, Genetic Genetics Genotype Human Isolation And Purification Monkey Diseases Parasitology Phylogeny Primate Procedures Random Amplified Polymorphic Dna Rhodnius Saguinus Species Difference Transmission Trypanosoma Cruzi Veterinary Animal Aotidae Brasil Cebidae Chagas Disease Cytochromes B Dna, Protozoan Genotype Humans Insect Vectors Monkey Diseases Phylogeny Polymorphism, Genetic Primates Random Amplified Polymorphic Dna Technique Rhodnius Saguinus Species Specificity Trypanosoma Cruzi Marcili, Arlei Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission |
| topic_facet |
Biogeography Chagas Disease Cytochrome Disease Transmission Dna Hominid Insect Pathology Phylogenetics Phylogeny Primate Protozoan Animal Aotidae Brasil Cebidae Chagas Disease Cytochromes B Dna, Protozoan Genotype Humans Insect Vectors Monkey Diseases Phylogeny Polymorphism, Genetic Primates Random Amplified Polymorphic Dna Technique Rhodnius Saguinus Species Specificity Trypanosoma Cruzi Amazonia South America Cytochrome B Protozoal Dna Animals Aotidae Brasil Cebidae Chagas Disease Classification Disease Carrier Polymorphism, Genetic Genetics Genotype Human Isolation And Purification Monkey Diseases Parasitology Phylogeny Primate Procedures Random Amplified Polymorphic Dna Rhodnius Saguinus Species Difference Transmission Trypanosoma Cruzi Veterinary Animal Aotidae Brasil Cebidae Chagas Disease Cytochromes B Dna, Protozoan Genotype Humans Insect Vectors Monkey Diseases Phylogeny Polymorphism, Genetic Primates Random Amplified Polymorphic Dna Technique Rhodnius Saguinus Species Specificity Trypanosoma Cruzi |
| description |
In this study, we provide phylogenetic and biogeographic evidence that the Trypanosoma cruzi lineages T. cruzi I (TCI) and T. cruzi IIa (TCIIa) circulate amongst non-human primates in Brazilian Amazonia, and are transmitted by Rhodnius species in overlapping arboreal transmission cycles, sporadically infecting humans. TCI presented higher prevalence rates, and no lineages other than TCI and TCIIa were found in this study in wild monkeys and Rhodnius from the Amazonian region. We characterised TCI and TCIIa from wild primates (16 TCI and five TCIIa), Rhodnius spp. (13 TCI and nine TCIIa), and humans with Chagas disease associated with oral transmission (14 TCI and five TCIIa) in Brazilian Amazonia. To our knowledge, TCIIa had not been associated with wild monkeys until now. Polymorphisms of ssrDNA, cytochrome b gene sequences and randomly amplified polymorphic DNA (RAPD) patterns clearly separated TCIIa from TCIIb-e and TCI lineages, and disclosed small intra-lineage polymorphisms amongst isolates from Amazonia. These data are important in understanding the complexity of the transmission cycles, genetic structure, and evolutionary history of T. cruzi populations circulating in Amazonia, and they contribute to both the unravelling of human infection routes and the pathological peculiarities of Chagas disease in this region. © 2008 Australian Society for Parasitology Inc. |
| format |
Artigo |
| author |
Marcili, Arlei |
| author2 |
Valente, Vera da Costa Valente, Sebastiäo Aldo S. Junqueira, Ângela Cristina Veríssimo Silva, Flávia Maia da Pinto, Ana Yecê das Neves Naiff, Roberto Daibes Campaner, Marta Coura, José Rodrigues Camargo, Erney Plessmann Miles, Michael Alexander Teixeira, Marta Maria Geraldes |
| author2Str |
Valente, Vera da Costa Valente, Sebastiäo Aldo S. Junqueira, Ângela Cristina Veríssimo Silva, Flávia Maia da Pinto, Ana Yecê das Neves Naiff, Roberto Daibes Campaner, Marta Coura, José Rodrigues Camargo, Erney Plessmann Miles, Michael Alexander Teixeira, Marta Maria Geraldes |
| title |
Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission |
| title_short |
Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission |
| title_full |
Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission |
| title_fullStr |
Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission |
| title_full_unstemmed |
Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission |
| title_sort |
trypanosoma cruzi in brazilian amazonia: lineages tci and tciia in wild primates, rhodnius spp. and in humans with chagas disease associated with oral transmission |
| publisher |
International Journal for Parasitology |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/18449 |
| _version_ |
1787145433735233536 |
| score |
11.755432 |