Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon highland
Cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis (CL-Lguy) is endemic in the Brazilian Amazon, differing from L. braziliensis infection in clinical, diagnostic, and therapeutic aspects. T-cell reactivity to leishmanial antigens possibly involved in the pathogenesis of CL-Lguy was st...
| Autor principal: | Matta, Nubia E. |
|---|---|
| Outros Autores: | Nogueira, Ricardo S., Franco, A. M., Souza-e-Souza, Ilner de, Mattos, Marise da Silva, Oliveira-Neto, Manoel Paes P., Coutinho, Sérgio G., Leon, Leonor Laura Pinto, Da-Cruz, Alda Maria |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
American Journal of Tropical Medicine and Hygiene
2020
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| Assuntos: | |
| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/18461 |
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oai:repositorio:1-18461 |
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oai:repositorio:1-18461 Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon highland Matta, Nubia E. Nogueira, Ricardo S. Franco, A. M. Souza-e-Souza, Ilner de Mattos, Marise da Silva Oliveira-Neto, Manoel Paes P. Coutinho, Sérgio G. Leon, Leonor Laura Pinto Da-Cruz, Alda Maria Gamma Interferon Interleukin-10 Interleukin 5 Parasite Antigen Tumor Necrosis Factor-alpha Adolescent Adult Brasil Cell Proliferation Clinical Controlled Study Female Human Immune Response Immune System Leishmania Leishmaniasis Male Adolescent Adult Animal Antibodies, Protozoan Brasil Case-control Studies Cytokines Endemic Diseases Female Humans Leishmania Guyanensis Leishmaniasis, Mucocutaneous Lymphocyte Subsets Male Young Adult Leishmania Braziliensis Leishmania Guyanensis Cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis (CL-Lguy) is endemic in the Brazilian Amazon, differing from L. braziliensis infection in clinical, diagnostic, and therapeutic aspects. T-cell reactivity to leishmanial antigens possibly involved in the pathogenesis of CL-Lguy was studied herein. Variable lymphoprolif- erative responses (LPRs) to Leishmania antigens were found among the 23 studied patients, and 50% of them showed low or no response to these antigens. Active disease was associated with an enrichment of leishmanial-reactive T lymphocytes, mainly TCD4+. High and low interferon (IFN)-γ producers were observed.TNF-α,interleukin (IL)-10, and IL-5 were consistently detected. CL-Lguy displayed low antibody response in comparison to L. braziliensis patients. CL caused by L. braziliensis presented positive LPRs and higher IFN-γ production but undetectable IL-5. L. guyanensis seems to induce a down-regulation of the immune system compared with L. braziliensis. This finding could explain some aspects of clinical presentation of CL-Lguy, such as high tissue parasite burden and frequent resistance to therapy. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene. 2020-06-15T21:55:20Z 2020-06-15T21:55:20Z 2009 Artigo https://repositorio.inpa.gov.br/handle/1/18461 en Volume 80, Número 3, Pags. 339-344 Restrito American Journal of Tropical Medicine and Hygiene |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Gamma Interferon Interleukin-10 Interleukin 5 Parasite Antigen Tumor Necrosis Factor-alpha Adolescent Adult Brasil Cell Proliferation Clinical Controlled Study Female Human Immune Response Immune System Leishmania Leishmaniasis Male Adolescent Adult Animal Antibodies, Protozoan Brasil Case-control Studies Cytokines Endemic Diseases Female Humans Leishmania Guyanensis Leishmaniasis, Mucocutaneous Lymphocyte Subsets Male Young Adult Leishmania Braziliensis Leishmania Guyanensis |
| spellingShingle |
Gamma Interferon Interleukin-10 Interleukin 5 Parasite Antigen Tumor Necrosis Factor-alpha Adolescent Adult Brasil Cell Proliferation Clinical Controlled Study Female Human Immune Response Immune System Leishmania Leishmaniasis Male Adolescent Adult Animal Antibodies, Protozoan Brasil Case-control Studies Cytokines Endemic Diseases Female Humans Leishmania Guyanensis Leishmaniasis, Mucocutaneous Lymphocyte Subsets Male Young Adult Leishmania Braziliensis Leishmania Guyanensis Matta, Nubia E. Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon highland |
| topic_facet |
Gamma Interferon Interleukin-10 Interleukin 5 Parasite Antigen Tumor Necrosis Factor-alpha Adolescent Adult Brasil Cell Proliferation Clinical Controlled Study Female Human Immune Response Immune System Leishmania Leishmaniasis Male Adolescent Adult Animal Antibodies, Protozoan Brasil Case-control Studies Cytokines Endemic Diseases Female Humans Leishmania Guyanensis Leishmaniasis, Mucocutaneous Lymphocyte Subsets Male Young Adult Leishmania Braziliensis Leishmania Guyanensis |
| description |
Cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis (CL-Lguy) is endemic in the Brazilian Amazon, differing from L. braziliensis infection in clinical, diagnostic, and therapeutic aspects. T-cell reactivity to leishmanial antigens possibly involved in the pathogenesis of CL-Lguy was studied herein. Variable lymphoprolif- erative responses (LPRs) to Leishmania antigens were found among the 23 studied patients, and 50% of them showed low or no response to these antigens. Active disease was associated with an enrichment of leishmanial-reactive T lymphocytes, mainly TCD4+. High and low interferon (IFN)-γ producers were observed.TNF-α,interleukin (IL)-10, and IL-5 were consistently detected. CL-Lguy displayed low antibody response in comparison to L. braziliensis patients. CL caused by L. braziliensis presented positive LPRs and higher IFN-γ production but undetectable IL-5. L. guyanensis seems to induce a down-regulation of the immune system compared with L. braziliensis. This finding could explain some aspects of clinical presentation of CL-Lguy, such as high tissue parasite burden and frequent resistance to therapy. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene. |
| format |
Artigo |
| author |
Matta, Nubia E. |
| author2 |
Nogueira, Ricardo S. Franco, A. M. Souza-e-Souza, Ilner de Mattos, Marise da Silva Oliveira-Neto, Manoel Paes P. Coutinho, Sérgio G. Leon, Leonor Laura Pinto Da-Cruz, Alda Maria |
| author2Str |
Nogueira, Ricardo S. Franco, A. M. Souza-e-Souza, Ilner de Mattos, Marise da Silva Oliveira-Neto, Manoel Paes P. Coutinho, Sérgio G. Leon, Leonor Laura Pinto Da-Cruz, Alda Maria |
| title |
Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon highland |
| title_short |
Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon highland |
| title_full |
Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon highland |
| title_fullStr |
Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon highland |
| title_full_unstemmed |
Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon highland |
| title_sort |
leishmania (viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the brazilian amazon highland |
| publisher |
American Journal of Tropical Medicine and Hygiene |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/18461 |
| _version_ |
1787142608575791104 |
| score |
11.755432 |