Interaction of vitamin A and zinc in lactating rats. Experimental deficiency model
An experimental deficiency model of vitamin A and zinc in lactating rats was developed. The experimental design consisted in a depletion period of 4 weeks immediately after birth where test group animal received a casein based feed, deficient in zinc and vitamin A, and a control feed according to th...
| Autor principal: | Yuyama, Lucia Kiyoko Ozaki |
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| Outros Autores: | Cozzolino, Sílvia Maria Franciscato |
| Grau: | Artigo |
| Idioma: | pt_BR |
| Publicado em: |
Archivos Latinoamericanos de Nutricion
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/19430 |
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oai:repositorio:1-19430 |
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oai:repositorio:1-19430 Interaction of vitamin A and zinc in lactating rats. Experimental deficiency model Interação de zinco e vitamina A em ratos na lactação. Modelo de deficiência experimental. Yuyama, Lucia Kiyoko Ozaki Cozzolino, Sílvia Maria Franciscato Casein Retinol Zinc Animals Blood Body Weight Chemistry Diet Disease Model Drug Interaction Female Male Metabolism Rat Rat Strain Retinol Deficiency Suckling Animal Animal, Suckling Body Weight Caseins Diet Disease Models, Animals Drug Interactions Female Male Rats Rats, Inbred Strains Vitamin A Vitamin A Deficiency Zinc An experimental deficiency model of vitamin A and zinc in lactating rats was developed. The experimental design consisted in a depletion period of 4 weeks immediately after birth where test group animal received a casein based feed, deficient in zinc and vitamin A, and a control feed according to the recommendations of the Committee on Laboratory Animal Diets. Female Rathus norvergicus, var albinus (Rodentia, Mammalia) with 6 young males each were used. These came from the Biotério of the Faculdade de Ciências, Farmacêuticas of USP. At the end of the depletion period it was found that the weight of the males control group (109.1 g +/- 3.9 g) was significantly greater than that of the test group (40.8 g +/- 6.7 g). The same was true for the concentration of zinc in the femurs of these animals, in the control group the concentration was significantly greater (115.7 micrograms/g +/- 5.4 micrograms/g) than in the test group (35.5 micrograms/g +/- 3.3 micrograms). The concentration of vitamin A in the plasma of the control group (31.5 micrograms/dL +/- 2.5 micrograms/dL) also was significantly greater than the test group animals (8.9 micrograms/dL +/- 3.4 micrograms/dL). The concentration of hepatic vitamin A was similar for both groups. We can conclude that there was interaction of zinc and vitamin A, by liver and depletion in zinc. Although the plasmatic concentration of vitamin A indicates a depletion, this cannot be considered as total because of the hepatic reserves. 2020-06-15T22:08:34Z 2020-06-15T22:08:34Z 1995 Artigo https://repositorio.inpa.gov.br/handle/1/19430 pt_BR Volume 45, Número 4, Pags. 305-309 Restrito Archivos Latinoamericanos de Nutricion |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
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INPA-RI |
| language |
pt_BR |
| topic |
Casein Retinol Zinc Animals Blood Body Weight Chemistry Diet Disease Model Drug Interaction Female Male Metabolism Rat Rat Strain Retinol Deficiency Suckling Animal Animal, Suckling Body Weight Caseins Diet Disease Models, Animals Drug Interactions Female Male Rats Rats, Inbred Strains Vitamin A Vitamin A Deficiency Zinc |
| spellingShingle |
Casein Retinol Zinc Animals Blood Body Weight Chemistry Diet Disease Model Drug Interaction Female Male Metabolism Rat Rat Strain Retinol Deficiency Suckling Animal Animal, Suckling Body Weight Caseins Diet Disease Models, Animals Drug Interactions Female Male Rats Rats, Inbred Strains Vitamin A Vitamin A Deficiency Zinc Yuyama, Lucia Kiyoko Ozaki Interaction of vitamin A and zinc in lactating rats. Experimental deficiency model |
| topic_facet |
Casein Retinol Zinc Animals Blood Body Weight Chemistry Diet Disease Model Drug Interaction Female Male Metabolism Rat Rat Strain Retinol Deficiency Suckling Animal Animal, Suckling Body Weight Caseins Diet Disease Models, Animals Drug Interactions Female Male Rats Rats, Inbred Strains Vitamin A Vitamin A Deficiency Zinc |
| description |
An experimental deficiency model of vitamin A and zinc in lactating rats was developed. The experimental design consisted in a depletion period of 4 weeks immediately after birth where test group animal received a casein based feed, deficient in zinc and vitamin A, and a control feed according to the recommendations of the Committee on Laboratory Animal Diets. Female Rathus norvergicus, var albinus (Rodentia, Mammalia) with 6 young males each were used. These came from the Biotério of the Faculdade de Ciências, Farmacêuticas of USP. At the end of the depletion period it was found that the weight of the males control group (109.1 g +/- 3.9 g) was significantly greater than that of the test group (40.8 g +/- 6.7 g). The same was true for the concentration of zinc in the femurs of these animals, in the control group the concentration was significantly greater (115.7 micrograms/g +/- 5.4 micrograms/g) than in the test group (35.5 micrograms/g +/- 3.3 micrograms). The concentration of vitamin A in the plasma of the control group (31.5 micrograms/dL +/- 2.5 micrograms/dL) also was significantly greater than the test group animals (8.9 micrograms/dL +/- 3.4 micrograms/dL). The concentration of hepatic vitamin A was similar for both groups. We can conclude that there was interaction of zinc and vitamin A, by liver and depletion in zinc. Although the plasmatic concentration of vitamin A indicates a depletion, this cannot be considered as total because of the hepatic reserves. |
| format |
Artigo |
| author |
Yuyama, Lucia Kiyoko Ozaki |
| author2 |
Cozzolino, Sílvia Maria Franciscato |
| author2Str |
Cozzolino, Sílvia Maria Franciscato |
| title |
Interaction of vitamin A and zinc in lactating rats. Experimental deficiency model |
| title_short |
Interaction of vitamin A and zinc in lactating rats. Experimental deficiency model |
| title_full |
Interaction of vitamin A and zinc in lactating rats. Experimental deficiency model |
| title_fullStr |
Interaction of vitamin A and zinc in lactating rats. Experimental deficiency model |
| title_full_unstemmed |
Interaction of vitamin A and zinc in lactating rats. Experimental deficiency model |
| title_sort |
interaction of vitamin a and zinc in lactating rats. experimental deficiency model |
| publisher |
Archivos Latinoamericanos de Nutricion |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/19430 |
| _version_ |
1787143377421074432 |
| score |
11.675608 |