A new antimalarial quassinoid from Simaba guianensis
Two antimalarial quassinoids, gutolactone [1] and simalikalactone D [2], have been characterized by bioactivity-directed fractionation from the bark of Simaba guianensis collected near Manaus, Brazil. Compound 2 was previously isolated from Simaba multiflora and Quassia africana and shown to be an a...
| Autor principal: | Cabral, Jose A. |
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| Outros Autores: | McChesney, James Dewey, Milhous, Wilbur K. |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
Journal of Natural Products
2020
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| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/19509 |
| Resumo: |
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Two antimalarial quassinoids, gutolactone [1] and simalikalactone D [2], have been characterized by bioactivity-directed fractionation from the bark of Simaba guianensis collected near Manaus, Brazil. Compound 2 was previously isolated from Simaba multiflora and Quassia africana and shown to be an active antimalarial in vitro. This is the first occurrence of 1. The structure of the novel quassinoid was established by spectral methods including 2D nmr spectroscopy. © 1993, American Chemical Society. All rights reserved. |