Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon
The prevalence of chloroquine-resistant falciparum malaria was determined for humans living at 28 different sites in the Brazilian Amazon. Blood samples obtained from each patient were defibrinated, placed in vials containing 0.5% glucose and or chloroquine and incubated for 24 hours at 39-40°C with...
| Autor principal: | Ferraroni, JoséJ J. |
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| Outros Autores: | Speer, Clarence A., Hayes, J., Suzuki, Mamoru |
| Grau: | Artigo |
| Idioma: | English |
| Publicado em: |
American Journal of Tropical Medicine and Hygiene
2020
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| Assuntos: | |
| Acesso em linha: |
https://repositorio.inpa.gov.br/handle/1/19727 |
| id |
oai:repositorio:1-19727 |
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dspace |
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oai:repositorio:1-19727 Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon Ferraroni, JoséJ J. Speer, Clarence A. Hayes, J. Suzuki, Mamoru Chloroquine Animals Experiment Brasil Drug Resistance Drug Response Epidemiology Geographic Distribution In Vitro Study Malaria Plasmodium Falciparum Protozoon Animalsia Plasmodium Falciparum Protozoa The prevalence of chloroquine-resistant falciparum malaria was determined for humans living at 28 different sites in the Brazilian Amazon. Blood samples obtained from each patient were defibrinated, placed in vials containing 0.5% glucose and or chloroquine and incubated for 24 hours at 39-40°C without agitation. In vitro sensitivity of the parasite to four different concentrations of chloroquine was determined for each sample. After 24 hours of incubation, trophozoites of Plasmodium falciparum developed to schizonts in all control cultures (no chloroquine) as well as in 80.6, 48.4, 11.8 and 7.5% of the cultures containing 0.5, 1.0, 2.0, and 3.0 nmol chloroquine/ml blood, respectively. Chloroquine-resistant P. falciparum was found in blood samples from all 28 locations, indicating that such resistance is widely spread in the Brazilian Amazon. 2020-06-15T22:12:09Z 2020-06-15T22:12:09Z 1981 Artigo https://repositorio.inpa.gov.br/handle/1/19727 10.4269/ajtmh.1981.30.526 en Volume 30, Número 3, Pags. 526-530 Restrito American Journal of Tropical Medicine and Hygiene |
| institution |
Instituto Nacional de Pesquisas da Amazônia - Repositório Institucional |
| collection |
INPA-RI |
| language |
English |
| topic |
Chloroquine Animals Experiment Brasil Drug Resistance Drug Response Epidemiology Geographic Distribution In Vitro Study Malaria Plasmodium Falciparum Protozoon Animalsia Plasmodium Falciparum Protozoa |
| spellingShingle |
Chloroquine Animals Experiment Brasil Drug Resistance Drug Response Epidemiology Geographic Distribution In Vitro Study Malaria Plasmodium Falciparum Protozoon Animalsia Plasmodium Falciparum Protozoa Ferraroni, JoséJ J. Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon |
| topic_facet |
Chloroquine Animals Experiment Brasil Drug Resistance Drug Response Epidemiology Geographic Distribution In Vitro Study Malaria Plasmodium Falciparum Protozoon Animalsia Plasmodium Falciparum Protozoa |
| description |
The prevalence of chloroquine-resistant falciparum malaria was determined for humans living at 28 different sites in the Brazilian Amazon. Blood samples obtained from each patient were defibrinated, placed in vials containing 0.5% glucose and or chloroquine and incubated for 24 hours at 39-40°C without agitation. In vitro sensitivity of the parasite to four different concentrations of chloroquine was determined for each sample. After 24 hours of incubation, trophozoites of Plasmodium falciparum developed to schizonts in all control cultures (no chloroquine) as well as in 80.6, 48.4, 11.8 and 7.5% of the cultures containing 0.5, 1.0, 2.0, and 3.0 nmol chloroquine/ml blood, respectively. Chloroquine-resistant P. falciparum was found in blood samples from all 28 locations, indicating that such resistance is widely spread in the Brazilian Amazon. |
| format |
Artigo |
| author |
Ferraroni, JoséJ J. |
| author2 |
Speer, Clarence A. Hayes, J. Suzuki, Mamoru |
| author2Str |
Speer, Clarence A. Hayes, J. Suzuki, Mamoru |
| title |
Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon |
| title_short |
Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon |
| title_full |
Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon |
| title_fullStr |
Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon |
| title_full_unstemmed |
Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon |
| title_sort |
prevalence of chloroquine-resistant falciparum malaria in the brazilian amazon |
| publisher |
American Journal of Tropical Medicine and Hygiene |
| publishDate |
2020 |
| url |
https://repositorio.inpa.gov.br/handle/1/19727 |
| _version_ |
1787141072463331328 |
| score |
11.755432 |