RESUMO EM OUTRO IDIOMA
OPCIONAL E NÃO REPETITIVO – Inglês: Abstract (dc.description.abstract); Francês: Résumé (dc.description.resume); Espanhol: Resumen (dc.description.resumen); Italiano: Riassunto (dc.description.riassunto); Alemão: Zusammenfassung (dc.description.zusammenfassung); Resumo Indígena (dc.description.indigena). Fonte: PDF
Epilepsy is a neurological disorder characterized by the permanent predisposition of the brain to
generate epileptic seizures, which affects about 1% of the world population. In Brazil, the disease
can reach 2% to 4% of the population. Most patients have a good prognosis for drug treatment,
however 30% of patients are refractory to treatment. Among the epilepsies that do not present a
good prognosis is the Temporal Lobe Epilepsy (ELT). ELT is characterized morphologically by a
selective loss of hippocampal neurons, concomitantly with increased hippocampal neurogenesis. It
is believed that this exacerbated neurogenesis contributes to epileptogenesis (onset of epilepsy);
however, the role of this increased neurogenesis in patients with TLE remains unknown. We used
hippocampus from patients with epilepsy, who underwent a surgical procedure in which unilateral
hippocampal resection was performed. From the analysis of the same, a possible relationship
between neurogenic patterns and the evolution of the disease was investigated. Interviews with
patients who underwent surgery demonstrated that the triggering event (precipitant) of epilepsy
occurred in the first years of life of the patients. In addition, they were high intensity events, and
also presented a high frequency of epileptic seizures and drug refractoriness. Immunohistochemical
analysis of hippocampi showed equivalently that there was a perceptible dispersion of the granule
cell layer, indicating a possible ectopic migration in labeling for neuroblasts (immature neurons),
which are generated in neurogenesis. The results obtained in this work are pioneer, given that they
are based on both clinical and histopathological findings, and the relationship between hippocampal
neurogenesis and clinical history proposes a new research vision. These findings may also help in a
new perspective of differential treatment in temporal lobe epilepsies.
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