Effect of copaiba oil in hepatic damage induced by acetaminophen in rats
PURPOSE: To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol. METHODS: Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copa...
| Autor principal: | TEIXEIRA, Renan Kleber Costa |
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| Outros Autores: | YAMAKI, Vitor Nagai, YASOJIMA, Edson Yuzur, BRITO, Marcus Vinicius Henriques |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2015
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| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/6338 http://dx.doi.org/10.1590/S0102-86502013000700008 |
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ir-2011-6338 |
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ir-2011-63382020-01-28T05:28:02Z Effect of copaiba oil in hepatic damage induced by acetaminophen in rats TEIXEIRA, Renan Kleber Costa YAMAKI, Vitor Nagai YASOJIMA, Edson Yuzur BRITO, Marcus Vinicius Henriques Planta oleaginosa Óleo de copaíba Doença hepática crônica induzida por droga Hepatite Paracetamol Rato como animal de laboratório PURPOSE: To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol. METHODS: Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase, GT, total bilirubin, direct bilirubin and indirect bilirubin and histological analisis were analized. RESULTS: The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and GT (p>0.05). The therapy copaiba group showed the highest levels of bilirubin and was statistically different from the other groups (p<0.01) and this increased the costs of direct bilirubin. Regarding histopathology, the oil of copaiba administered prophylactic or therapeutic form for 7 days could decrease the amount of necrosis and inflammatory infiltrate. CONCLUSION: Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect. YASOJIMA, E. Y. Universidade Federal do Pará 2015-02-24T17:08:41Z 2015-02-24T17:08:41Z 2013-07 Artigo de Periódico TEIXEIRA, Renan Kleber Costa et al. Effect of copaiba oil in hepatic damage induced by acetaminophen in rats. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 7, p. 526-530, July 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000700008. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6338. Acesso em:. 1678-2674 http://repositorio.ufpa.br/jspui/handle/2011/6338 http://dx.doi.org/10.1590/S0102-86502013000700008 eng Acta Cirúrgica Brasileira Acesso Aberto application/pdf Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Brasil SOBRADPEC http://ref.scielo.org/65wntn |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Planta oleaginosa Óleo de copaíba Doença hepática crônica induzida por droga Hepatite Paracetamol Rato como animal de laboratório |
| spellingShingle |
Planta oleaginosa Óleo de copaíba Doença hepática crônica induzida por droga Hepatite Paracetamol Rato como animal de laboratório TEIXEIRA, Renan Kleber Costa Effect of copaiba oil in hepatic damage induced by acetaminophen in rats |
| topic_facet |
Planta oleaginosa Óleo de copaíba Doença hepática crônica induzida por droga Hepatite Paracetamol Rato como animal de laboratório |
| description |
PURPOSE: To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol.
METHODS: Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase, GT, total bilirubin, direct bilirubin and indirect bilirubin and histological analisis were analized.
RESULTS: The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and GT (p>0.05). The therapy copaiba group showed the highest levels of bilirubin and was statistically different from the other groups (p<0.01) and this increased the costs of direct bilirubin. Regarding histopathology, the oil of copaiba administered prophylactic or therapeutic form for 7 days could decrease the amount of necrosis and inflammatory infiltrate.
CONCLUSION: Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect. |
| format |
Artigo |
| author |
TEIXEIRA, Renan Kleber Costa |
| author2 |
YAMAKI, Vitor Nagai YASOJIMA, Edson Yuzur BRITO, Marcus Vinicius Henriques |
| author2Str |
YAMAKI, Vitor Nagai YASOJIMA, Edson Yuzur BRITO, Marcus Vinicius Henriques |
| title |
Effect of copaiba oil in hepatic damage induced by acetaminophen in rats |
| title_short |
Effect of copaiba oil in hepatic damage induced by acetaminophen in rats |
| title_full |
Effect of copaiba oil in hepatic damage induced by acetaminophen in rats |
| title_fullStr |
Effect of copaiba oil in hepatic damage induced by acetaminophen in rats |
| title_full_unstemmed |
Effect of copaiba oil in hepatic damage induced by acetaminophen in rats |
| title_sort |
effect of copaiba oil in hepatic damage induced by acetaminophen in rats |
| publisher |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| publishDate |
2015 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/6338 http://dx.doi.org/10.1590/S0102-86502013000700008 |
| _version_ |
1832603169825226752 |
| score |
11.755432 |