Artigo

Immediate graft histological assay, post pig's liver transplantation

PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation...

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Autor principal: BRITO, Marcus Vinicius Henriques
Outros Autores: ARAÚJO, Marialva Tereza Ferreira de, CUNHA, Luane Cristine Batista, OLIVEIRA, Antônio Jorge Barbosa de, RODRIGUES, Jacqueline Barreto, BRITO, Nathalya Botelho
Grau: Artigo
Idioma: eng
Publicado em: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2015
Assuntos:
Histologia
Transplante de fígado
Suíno
Liver transplantation
Histology
Swine
Acesso em linha: http://repositorio.ufpa.br/jspui/handle/2011/6346
http://dx.doi.org/10.1590/S0102-86502013000900009
id ir-2011-6346
recordtype dspace
spelling ir-2011-63462020-01-27T16:27:04Z Immediate graft histological assay, post pig's liver transplantation BRITO, Marcus Vinicius Henriques ARAÚJO, Marialva Tereza Ferreira de CUNHA, Luane Cristine Batista OLIVEIRA, Antônio Jorge Barbosa de RODRIGUES, Jacqueline Barreto BRITO, Nathalya Botelho Histologia Transplante de fígado Suíno Liver transplantation Histology Swine PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3. RESULTS: Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7. CONCLUSIONS: The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells. CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico ARAÚJO, M. T. F.; CUNHA, L. C. B. Universidade Federal do Pará 2015-02-25T14:46:28Z 2015-02-25T14:46:28Z 2013-09 Artigo de Periódico BRITO, Marcus Vinicius Henriques et al. Immediate graft histological assay, post pig's liver transplantation. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 9, p. 678-682, Sept. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000900009. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6346. Acesso em:. 1678-2674 http://repositorio.ufpa.br/jspui/handle/2011/6346 http://dx.doi.org/10.1590/S0102-86502013000900009 eng Acta Cirúrgica Brasileira Acesso Aberto application/pdf Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Brasil SOBRADPEC http://ref.scielo.org/hrprb7
institution Repositório Institucional - Universidade Federal do Pará
collection RI-UFPA
language eng
topic Histologia
Transplante de fígado
Suíno
Liver transplantation
Histology
Swine
spellingShingle Histologia
Transplante de fígado
Suíno
Liver transplantation
Histology
Swine
BRITO, Marcus Vinicius Henriques
Immediate graft histological assay, post pig's liver transplantation
topic_facet Histologia
Transplante de fígado
Suíno
Liver transplantation
Histology
Swine
description PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3. RESULTS: Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7. CONCLUSIONS: The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells.
format Artigo
author BRITO, Marcus Vinicius Henriques
author2 ARAÚJO, Marialva Tereza Ferreira de
CUNHA, Luane Cristine Batista
OLIVEIRA, Antônio Jorge Barbosa de
RODRIGUES, Jacqueline Barreto
BRITO, Nathalya Botelho
author2Str ARAÚJO, Marialva Tereza Ferreira de
CUNHA, Luane Cristine Batista
OLIVEIRA, Antônio Jorge Barbosa de
RODRIGUES, Jacqueline Barreto
BRITO, Nathalya Botelho
title Immediate graft histological assay, post pig's liver transplantation
title_short Immediate graft histological assay, post pig's liver transplantation
title_full Immediate graft histological assay, post pig's liver transplantation
title_fullStr Immediate graft histological assay, post pig's liver transplantation
title_full_unstemmed Immediate graft histological assay, post pig's liver transplantation
title_sort immediate graft histological assay, post pig's liver transplantation
publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publishDate 2015
url http://repositorio.ufpa.br/jspui/handle/2011/6346
http://dx.doi.org/10.1590/S0102-86502013000900009
_version_ 1832605272844009472
score 11.755432

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