Copaiba oil effect on experimental jaw defect in Wistar rats

SILVA, Priscilla Flores; BRITO, Marcus Vinicius Henriques; PONTES, Flávia Sirotheau Corrêa; RAMOS, Suzana Rodrigues; MENDES, Laís Cordeiro; OLIVEIRA, Louize Caroline Marques

Artigo

Copaiba oil effect on experimental jaw defect in Wistar rats

PURPOSE: To evaluate the effects of copaiba oil on jaw defects repair in Wistar rats treated with bioglass or adipose tissue. METHODS: A jaw defect was randomly created in forty-two rats and filled with bioglass or adipose tissue. The two groups (Gbio and Gcell) were subdivided in three subgroups wi...

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Autor principal:	SILVA, Priscilla Flores
Outros Autores:	BRITO, Marcus Vinicius Henriques, PONTES, Flávia Sirotheau Corrêa, RAMOS, Suzana Rodrigues, MENDES, Laís Cordeiro, OLIVEIRA, Louize Caroline Marques
Grau:	Artigo
Idioma:	eng
Publicado em:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2015
Assuntos:	Plantas medicinais Óleo de copaíba Regeneração óssea Anti-inflamatórios Rato como animal de laboratório Plants Medicinal Bone regeneration Anti-Inflammatory agents
Acesso em linha:	http://repositorio.ufpa.br/jspui/handle/2011/6488 http://dx.doi.org/10.1590/S0102-86502015002000006

id	ir-2011-6488
recordtype	dspace
spelling	ir-2011-64882020-01-27T16:27:29Z Copaiba oil effect on experimental jaw defect in Wistar rats SILVA, Priscilla Flores BRITO, Marcus Vinicius Henriques PONTES, Flávia Sirotheau Corrêa RAMOS, Suzana Rodrigues MENDES, Laís Cordeiro OLIVEIRA, Louize Caroline Marques Plantas medicinais Óleo de copaíba Regeneração óssea Anti-inflamatórios Rato como animal de laboratório Plants Medicinal Bone regeneration Anti-Inflammatory agents PURPOSE: To evaluate the effects of copaiba oil on jaw defects repair in Wistar rats treated with bioglass or adipose tissue. METHODS: A jaw defect was randomly created in forty-two rats and filled with bioglass or adipose tissue. The two groups (Gbio and Gcell) were subdivided in three subgroups with seven animals each according to gavage administration: control (distillated water), oil (copaiba oil) and melox (meloxicam). Euthanasia was performed after forty post-operative days. The bone formation was analyzed regarding the histological aspects. RESULTS: The osteoclasts activity was observed only in four subgroups (p=0.78). Regarding the osteoblasts presence, it was very similar between the subgroups, the difference was due to Gcell-melox (p=0.009) that presented less osteoblastic activity. The inflammatory cells were more evident in Gcell-melox subgroup, however, there was no difference in comparison with the other subgroups (p=0.52). Bone formation was observed in all subgroups, just two animals showed no bone formation even after 40 days. More than 50% of bone matrix mineralization was observed in 56% (23 animals) of the analyzed areas. The bone matrix mineralization was not different between subgroups (p=0.60). CONCLUSIONS: The subgroups that received copaiba oil showed bone repair, although not statistically significant in comparison to subgroups treated whit meloxicam or controls. Copaiba oil administered by gavage had no effect on bone repair in this experimental model. SILVA, P. F.; PONTES, F. S. C.; MENDES, L. C.; OLIVEIRA, L. C. M. Universidade Federal do Pará 2015-03-25T13:36:19Z 2015-03-25T13:36:19Z 2015-02 Artigo de Periódico SILVA, Priscilla Flores et al. Copaiba oil effect on experimental jaw defect in Wistar rats. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 2, p. 120-126, Feb. 2015. DOI: http://dx.doi.org/10.1590/S0102-86502015002000006. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6488. Acesso em:. 1678-2674 http://repositorio.ufpa.br/jspui/handle/2011/6488 http://dx.doi.org/10.1590/S0102-86502015002000006 eng Acta Cirúrgica Brasileira Acesso Aberto application/pdf Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia SOBRADPEC http://ref.scielo.org/t7654c
institution	Repositório Institucional - Universidade Federal do Pará
collection	RI-UFPA
language	eng
topic	Plantas medicinais Óleo de copaíba Regeneração óssea Anti-inflamatórios Rato como animal de laboratório Plants Medicinal Bone regeneration Anti-Inflammatory agents
spellingShingle	Plantas medicinais Óleo de copaíba Regeneração óssea Anti-inflamatórios Rato como animal de laboratório Plants Medicinal Bone regeneration Anti-Inflammatory agents SILVA, Priscilla Flores Copaiba oil effect on experimental jaw defect in Wistar rats
topic_facet	Plantas medicinais Óleo de copaíba Regeneração óssea Anti-inflamatórios Rato como animal de laboratório Plants Medicinal Bone regeneration Anti-Inflammatory agents
description	PURPOSE: To evaluate the effects of copaiba oil on jaw defects repair in Wistar rats treated with bioglass or adipose tissue. METHODS: A jaw defect was randomly created in forty-two rats and filled with bioglass or adipose tissue. The two groups (Gbio and Gcell) were subdivided in three subgroups with seven animals each according to gavage administration: control (distillated water), oil (copaiba oil) and melox (meloxicam). Euthanasia was performed after forty post-operative days. The bone formation was analyzed regarding the histological aspects. RESULTS: The osteoclasts activity was observed only in four subgroups (p=0.78). Regarding the osteoblasts presence, it was very similar between the subgroups, the difference was due to Gcell-melox (p=0.009) that presented less osteoblastic activity. The inflammatory cells were more evident in Gcell-melox subgroup, however, there was no difference in comparison with the other subgroups (p=0.52). Bone formation was observed in all subgroups, just two animals showed no bone formation even after 40 days. More than 50% of bone matrix mineralization was observed in 56% (23 animals) of the analyzed areas. The bone matrix mineralization was not different between subgroups (p=0.60). CONCLUSIONS: The subgroups that received copaiba oil showed bone repair, although not statistically significant in comparison to subgroups treated whit meloxicam or controls. Copaiba oil administered by gavage had no effect on bone repair in this experimental model.
format	Artigo
author	SILVA, Priscilla Flores
author2	BRITO, Marcus Vinicius Henriques PONTES, Flávia Sirotheau Corrêa RAMOS, Suzana Rodrigues MENDES, Laís Cordeiro OLIVEIRA, Louize Caroline Marques
author2Str	BRITO, Marcus Vinicius Henriques PONTES, Flávia Sirotheau Corrêa RAMOS, Suzana Rodrigues MENDES, Laís Cordeiro OLIVEIRA, Louize Caroline Marques
title	Copaiba oil effect on experimental jaw defect in Wistar rats
title_short	Copaiba oil effect on experimental jaw defect in Wistar rats
title_full	Copaiba oil effect on experimental jaw defect in Wistar rats
title_fullStr	Copaiba oil effect on experimental jaw defect in Wistar rats
title_full_unstemmed	Copaiba oil effect on experimental jaw defect in Wistar rats
title_sort	copaiba oil effect on experimental jaw defect in wistar rats
publisher	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publishDate	2015
url	http://repositorio.ufpa.br/jspui/handle/2011/6488 http://dx.doi.org/10.1590/S0102-86502015002000006
_version_	1832603378665914368
score	11.755432

Copaiba oil effect on experimental jaw defect in Wistar rats

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