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Tese
Análise do dano neural em pacientes hansenianos e na coinfecção HIV/ Hanseníase através de duas coortes clínicas
In Brazil where leprosy is endemic and where HIV infection continues to expand and internalizing, if expected to find an increased prevalence of individuals living with both leprosy and HIV / AIDS, but there are few reports on the neurological damage that can cause overlapping. The aim of this stud...
Autor principal: | BATISTA, Keila de Nazaré Madureira |
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Grau: | Tese |
Idioma: | por |
Publicado em: |
Universidade Federal do Pará
2015
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Assuntos: | |
Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/6799 |
Resumo: |
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In Brazil where leprosy is endemic and where HIV infection continues to expand and internalizing, if expected to find an increased prevalence of individuals living with both leprosy and HIV / AIDS, but there are few reports on the neurological damage that can cause
overlapping. The aim of this study was to investigate nerve damage in leprosy leprosy patients
coinfected with human immunodeficiency virus, compared with leprosy coinfected not at the
beginning of treatment and at discharge, through two clinical cohorts. The sample consisted of 99
patients of whom 46 had coinfection MH / HIV and only 53 leprosy, these patients were seen at
the outpatient clinic of the Center for Tropical Medicine and evaluated by the Simplified
Technique. As a result there was a predominance of males, aged between 15 and 45 and the
origin of the Metropolitan Region of Belém In group coinfection MH / HIV were prevalent in
these paucibacillary patients and the presence of neuritis , abnormal sensitivity , motor
abnormalities, presence of disability and neural damage was higher in this group than in the MH.
In group predominated MH multibacillary patients and the presence of these neuritis, abnormal
sensitivity, motor abnormalities, presence of disability and nerve damage was higher in this group
than in coinfected MH / HIV. Monitoring of patients coinfected MH / HIV there was a small
reduction in the presence of failure and nerve damage while in the MH group monitoring the
presence of disability remained increased and nerve damage. In the Kaplan-Meier survival
analysis was found that in patients MH was maintaining the chance of the patient remains without
nerve damage, while in the coinfected patients group, was observed a reduction in the chance of
the patient to keep without nerve damage the end of treatment. Thus it is concluded that the
neural damage behaves differently in the two groups manner, predominantly in the paucibacillary
group coinfected patients coinfected and not in multibacillary patients, but with the same gravity,
which is troubling since diagnosing this damage at the beginning of the appearance of leprosy is
still a problem for public health. |