Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
Penicillium janthinellum, isolated as an endophytic fungus from fruits of Melia azedarach, was cultivated over 20 days on ground and autoclaved white corn, where the known polyketides citrinin, emodin, 1,6,8-trihydroxy-3-hydroxymethylanthraquinone, and a new modified anthraquinone, named janthinone,...
| Autor principal: | MARINHO, Andrey Moacir do Rosário |
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| Outros Autores: | RODRIGUES FILHO, Edson, MOITINHO, Maria da Luz Ribeiro, SANTOS, Lourivaldo da Silva |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
2015
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| Acesso em linha: |
http://repositorio.ufpa.br/jspui/handle/2011/6974 |
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ir-2011-6974 |
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ir-2011-69742017-12-22T14:29:48Z Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach MARINHO, Andrey Moacir do Rosário RODRIGUES FILHO, Edson MOITINHO, Maria da Luz Ribeiro SANTOS, Lourivaldo da Silva Espectroscopia Fungo endofítico Melia azedarach Leishmania Policetídeos Penicillium janthinellum, isolated as an endophytic fungus from fruits of Melia azedarach, was cultivated over 20 days on ground and autoclaved white corn, where the known polyketides citrinin, emodin, 1,6,8-trihydroxy-3-hydroxymethylanthraquinone, and a new modified anthraquinone, named janthinone, were produced and isolated by classical chromatographic procedures and identified by MS and 1D and 2D NMR spectroscopic data. The antibacterial properties of these polyketides were investigated. Citrinin inhibited 100% of Leishmania growth after 48h at a concentration of 40 μg mL-1. Penicillium janthinellum, isolado como um fungo endofítico dos frutos de Melia azedarach, foi cultivado por 20 dias em milho branco triturado e autoclavado, onde os policetídeos conhecidos citrinina, emodina, 1,6,8-triidróxi-3-hidroximetilantraquinona, e uma nova antraquinona modificada, denominada janthinona, foram produzidos e isolados por procedimentos cromatográficos clássicos e identificados por extensivos estudos espectroscópicos, principalmente RMN 1D e 2D e EM. Essas substâncias foram ensaiadas contra diversas bactérias. Citrinina foi ensaiada pela primeira vez contra Leishmania e inibiu 100% o crescimento de cepas depois de 48h a uma concentração de 40 μg mL-1. 2015-11-09T16:27:12Z 2015-11-09T16:27:12Z 2005-04 Artigo de Periódico MARINHO, Andrey Moacir do Rosario et al. Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach. Journal of the Brazilian Chemical Society, São Paulo, v. 16, n. 2, p. 280-283, abr. 2005. Disponível em: <http://www.scielo.br/pdf/jbchs/v16n2/en_a23v16n2.pdf>. Acesso em: 6 nov. 2015. <http://dx.doi.org/10.1590/S0103-50532005000200023>. 1678-4790 http://repositorio.ufpa.br/jspui/handle/2011/6974 eng Acesso Aberto application/pdf |
| institution |
Repositório Institucional - Universidade Federal do Pará |
| collection |
RI-UFPA |
| language |
eng |
| topic |
Espectroscopia Fungo endofítico Melia azedarach Leishmania Policetídeos |
| spellingShingle |
Espectroscopia Fungo endofítico Melia azedarach Leishmania Policetídeos MARINHO, Andrey Moacir do Rosário Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach |
| topic_facet |
Espectroscopia Fungo endofítico Melia azedarach Leishmania Policetídeos |
| description |
Penicillium janthinellum, isolated as an endophytic fungus from fruits of Melia azedarach, was cultivated over 20 days on ground and autoclaved white corn, where the known polyketides citrinin, emodin, 1,6,8-trihydroxy-3-hydroxymethylanthraquinone, and a new modified anthraquinone, named janthinone, were produced and isolated by classical chromatographic procedures and identified by MS and 1D and 2D NMR spectroscopic data. The antibacterial properties of these polyketides were investigated. Citrinin inhibited 100% of Leishmania growth after 48h at a concentration of 40 μg mL-1. |
| format |
Artigo |
| author |
MARINHO, Andrey Moacir do Rosário |
| author2 |
RODRIGUES FILHO, Edson MOITINHO, Maria da Luz Ribeiro SANTOS, Lourivaldo da Silva |
| author2Str |
RODRIGUES FILHO, Edson MOITINHO, Maria da Luz Ribeiro SANTOS, Lourivaldo da Silva |
| title |
Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach |
| title_short |
Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach |
| title_full |
Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach |
| title_fullStr |
Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach |
| title_full_unstemmed |
Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach |
| title_sort |
biologically active polyketides produced by penicillium janthinellum isolated as an endophytic fungus from fruits of melia azedarach |
| publishDate |
2015 |
| url |
http://repositorio.ufpa.br/jspui/handle/2011/6974 |
| _version_ |
1832603437760512000 |
| score |
11.755432 |