SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria
Aim: The association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. Patients & methods: Totally, 164 Plasmodium vivax malaria infected patients were included. Generalized estimating equations were performed to det...
| Autor principal: | Sortica, Vinicius Albuquerque |
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| Outros Autores: | Lindenau, Juliana D., Cunha, Maristela G., Ohnishi, Maria Deise O., Ventura, Ana Maria Revoredo da Silva, Ribeiro-dos-Santos, ?ndrea K. C., Santos, Sidney E. B., Guimar?es, Luciano S. P., Hutz, Mara H. |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Future Medicine
2017
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| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/2835 |
| Resumo: |
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Aim: The association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. Patients & methods: Totally, 164 Plasmodium vivax malaria infected patients were included. Generalized estimating equations were performed to determine gene influences on parasitemia and/or gametocytemia clearance over treatment time. Results: Significant interaction between SLCO2B1 genotypes and treatment over time for parasitemia clearance rate on day 2 were observed (p FDR = 0.002). SLCO1A2 and SLCO1B1 gene treatment over time interactions were associated with gametocytemia clearance rate (p FDR = 0.018 and p FDR = 0.024). ABCB1, ABCC4 and SLCO1B3 were not associated with treatment response. Conclusion: The present work presents the first pharmacogenetic report of an association between chloroquine/primaquine responses with OATP transporters. |