SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria
Aim: The association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. Patients & methods: Totally, 164 Plasmodium vivax malaria infected patients were included. Generalized estimating equations were performed to det...
| Autor principal: | Sortica, Vinicius Albuquerque |
|---|---|
| Outros Autores: | Lindenau, Juliana D., Cunha, Maristela G., Ohnishi, Maria Deise O., Ventura, Ana Maria Revoredo da Silva, Ribeiro-dos-Santos, ?ndrea K. C., Santos, Sidney E. B., Guimar?es, Luciano S. P., Hutz, Mara H. |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Future Medicine
2017
|
| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/2835 |
| id |
ir-iec-2835 |
|---|---|
| recordtype |
dspace |
| spelling |
ir-iec-28352021-04-08T18:16:38Z SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria Sortica, Vinicius Albuquerque Lindenau, Juliana D. Cunha, Maristela G. Ohnishi, Maria Deise O. Ventura, Ana Maria Revoredo da Silva Ribeiro-dos-Santos, ?ndrea K. C. Santos, Sidney E. B. Guimar?es, Luciano S. P. Hutz, Mara H. Cloroquina / administra??o & dosagem Primaquina / administra??o & dosagem Polimorfismo Gen?tico Testes Farmacogen?micos Mal?ria Plasmodium vivax Aim: The association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. Patients & methods: Totally, 164 Plasmodium vivax malaria infected patients were included. Generalized estimating equations were performed to determine gene influences on parasitemia and/or gametocytemia clearance over treatment time. Results: Significant interaction between SLCO2B1 genotypes and treatment over time for parasitemia clearance rate on day 2 were observed (p FDR = 0.002). SLCO1A2 and SLCO1B1 gene treatment over time interactions were associated with gametocytemia clearance rate (p FDR = 0.018 and p FDR = 0.024). ABCB1, ABCC4 and SLCO1B3 were not associated with treatment response. Conclusion: The present work presents the first pharmacogenetic report of an association between chloroquine/primaquine responses with OATP transporters. Financial support was provided by Conselho Nacional de Desenvolvimento Cient??fico e Tecnologico (CNPq, Brazil) 2017-11-07T14:06:13Z 2017-11-07T14:06:13Z 2017 Artigo SORTICA, Vinicius A. et al. SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria. Pharmacogenomics, v. 18, n. 15, p. 1393-1400, Oct. 2017. 1462-2416 http://patua.iec.gov.br//handle/iec/2835 10.2217/pgs-2017-0077 eng Acesso Aberto application/pdf Future Medicine |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Cloroquina / administra??o & dosagem Primaquina / administra??o & dosagem Polimorfismo Gen?tico Testes Farmacogen?micos Mal?ria Plasmodium vivax |
| spellingShingle |
Cloroquina / administra??o & dosagem Primaquina / administra??o & dosagem Polimorfismo Gen?tico Testes Farmacogen?micos Mal?ria Plasmodium vivax Sortica, Vinicius Albuquerque SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria |
| topic_facet |
Cloroquina / administra??o & dosagem Primaquina / administra??o & dosagem Polimorfismo Gen?tico Testes Farmacogen?micos Mal?ria Plasmodium vivax |
| description |
Aim: The association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. Patients & methods: Totally, 164 Plasmodium vivax malaria infected patients were included. Generalized estimating equations were performed to determine gene influences on parasitemia and/or gametocytemia clearance over treatment time. Results: Significant interaction between SLCO2B1 genotypes and treatment over time for parasitemia clearance rate on day 2 were observed (p FDR = 0.002). SLCO1A2 and SLCO1B1 gene treatment over time interactions were associated with gametocytemia clearance rate (p FDR = 0.018 and p FDR = 0.024). ABCB1, ABCC4 and SLCO1B3 were not associated with treatment response. Conclusion: The present work presents the first pharmacogenetic report of an association between chloroquine/primaquine responses with OATP transporters. |
| format |
Artigo |
| author |
Sortica, Vinicius Albuquerque |
| author2 |
Lindenau, Juliana D. Cunha, Maristela G. Ohnishi, Maria Deise O. Ventura, Ana Maria Revoredo da Silva Ribeiro-dos-Santos, ?ndrea K. C. Santos, Sidney E. B. Guimar?es, Luciano S. P. Hutz, Mara H. |
| author2Str |
Lindenau, Juliana D. Cunha, Maristela G. Ohnishi, Maria Deise O. Ventura, Ana Maria Revoredo da Silva Ribeiro-dos-Santos, ?ndrea K. C. Santos, Sidney E. B. Guimar?es, Luciano S. P. Hutz, Mara H. |
| title |
SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria |
| title_short |
SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria |
| title_full |
SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria |
| title_fullStr |
SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria |
| title_full_unstemmed |
SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria |
| title_sort |
slco1a2, slco1b1 and slco2b1 polymorphisms influences chloroquine and primaquine treatment in plasmodium vivax malaria |
| publisher |
Future Medicine |
| publishDate |
2017 |
| url |
http://patua.iec.gov.br//handle/iec/2835 |
| _version_ |
1717584501990752256 |
| score |
11.755432 |