Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats
Few genetic markers have been described to analyze populations of Plasmodium vivax . The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These studies of genetic variability have neglected many areas with different e...
| Autor principal: | Rezende, Ant?nio M |
|---|---|
| Outros Autores: | Santos, Eduardo Tarazona, Couto, ?lvaro D'Almeida, Fontes, C?r J?sus F, Souza, Jos? Maria de, Carvalho, Luzia H, Brito, Cristiana F. A |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
American Society of Tropical Medicine and Hygiene
2019
|
| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3571 |
| Resumo: |
|---|
|
Few genetic markers have been described to analyze populations of Plasmodium vivax . The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These
studies of genetic variability have neglected many areas with different epidemiologic profiles. The purpose of this study
was to analyze the genetic variability of P. vivax isolates from four different Brazilian Amazon areas. We chose to study the
five most polymorphic tandem repeats (TRs) identified so far. All TRs studied were polymorphic in at least one studied
population, with a modal allele at nearly all loci. Expected heterozygosity ranged from 0.462 to 0.666 and did not correlate
with the repeat array length. The genetic distances among the populations varied from 0.027 to 0.241, and did not correlate
with their geographic separation. Tandem repeats identified in P. vivax isolates failed to allow geographic clustering. |