Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats
Few genetic markers have been described to analyze populations of Plasmodium vivax . The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These studies of genetic variability have neglected many areas with different e...
| Autor principal: | Rezende, Ant?nio M |
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| Outros Autores: | Santos, Eduardo Tarazona, Couto, ?lvaro D'Almeida, Fontes, C?r J?sus F, Souza, Jos? Maria de, Carvalho, Luzia H, Brito, Cristiana F. A |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
American Society of Tropical Medicine and Hygiene
2019
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3571 |
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ir-iec-3571 |
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ir-iec-35712019-01-22T18:27:24Z Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats Rezende, Ant?nio M Santos, Eduardo Tarazona Couto, ?lvaro D'Almeida Fontes, C?r J?sus F Souza, Jos? Maria de Carvalho, Luzia H Brito, Cristiana F. A Mal?ria Vivax / parasitologia Plasmodium vivax / gen?tica Varia??o Gen?tica Mal?ria Vivax / epidemiologia Brasil / epidemiologia Few genetic markers have been described to analyze populations of Plasmodium vivax . The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These studies of genetic variability have neglected many areas with different epidemiologic profiles. The purpose of this study was to analyze the genetic variability of P. vivax isolates from four different Brazilian Amazon areas. We chose to study the five most polymorphic tandem repeats (TRs) identified so far. All TRs studied were polymorphic in at least one studied population, with a modal allele at nearly all loci. Expected heterozygosity ranged from 0.462 to 0.666 and did not correlate with the repeat array length. The genetic distances among the populations varied from 0.027 to 0.241, and did not correlate with their geographic separation. Tandem repeats identified in P. vivax isolates failed to allow geographic clustering. This work was supported by the Funda??o de Amparo ? Pesquisa de Minas Gerais (Fapemig), the Conselho Nacional de Pesquisa (CNPq), and PAPES/FIOCRUZ. 2019-01-22T18:06:19Z 2019-01-22T18:06:19Z 2009 Artigo REZENDE, Ant?nio M. et al. Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats. American Journal of Tropical Medicine and Hygiene, v. 80, n. 5, p. 729-733, 2009. 0002-9637 http://patua.iec.gov.br//handle/iec/3571 eng Acesso Aberto application/pdf American Society of Tropical Medicine and Hygiene |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Mal?ria Vivax / parasitologia Plasmodium vivax / gen?tica Varia??o Gen?tica Mal?ria Vivax / epidemiologia Brasil / epidemiologia |
| spellingShingle |
Mal?ria Vivax / parasitologia Plasmodium vivax / gen?tica Varia??o Gen?tica Mal?ria Vivax / epidemiologia Brasil / epidemiologia Rezende, Ant?nio M Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
| topic_facet |
Mal?ria Vivax / parasitologia Plasmodium vivax / gen?tica Varia??o Gen?tica Mal?ria Vivax / epidemiologia Brasil / epidemiologia |
| description |
Few genetic markers have been described to analyze populations of Plasmodium vivax . The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These
studies of genetic variability have neglected many areas with different epidemiologic profiles. The purpose of this study
was to analyze the genetic variability of P. vivax isolates from four different Brazilian Amazon areas. We chose to study the
five most polymorphic tandem repeats (TRs) identified so far. All TRs studied were polymorphic in at least one studied
population, with a modal allele at nearly all loci. Expected heterozygosity ranged from 0.462 to 0.666 and did not correlate
with the repeat array length. The genetic distances among the populations varied from 0.027 to 0.241, and did not correlate
with their geographic separation. Tandem repeats identified in P. vivax isolates failed to allow geographic clustering. |
| format |
Artigo |
| author |
Rezende, Ant?nio M |
| author2 |
Santos, Eduardo Tarazona Couto, ?lvaro D'Almeida Fontes, C?r J?sus F Souza, Jos? Maria de Carvalho, Luzia H Brito, Cristiana F. A |
| author2Str |
Santos, Eduardo Tarazona Couto, ?lvaro D'Almeida Fontes, C?r J?sus F Souza, Jos? Maria de Carvalho, Luzia H Brito, Cristiana F. A |
| title |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
| title_short |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
| title_full |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
| title_fullStr |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
| title_full_unstemmed |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
| title_sort |
analysis of genetic variability of plasmodium vivax isolates from different brazilian amazon areas using tandem repeats |
| publisher |
American Society of Tropical Medicine and Hygiene |
| publishDate |
2019 |
| url |
http://patua.iec.gov.br//handle/iec/3571 |
| _version_ |
1717584375082647552 |
| score |
11.755432 |