Detection and molecular epidemiology of human bocavirus in children with acute gastroenteritis from Brazil
Human Bocavirus (HBoV) is a recently discovered virus and was first detected in the nasopharyngeal aspirate samples and after in stool samples, suggesting that HBoV may be a causative agent for human enteric infections. Due to absence of treatment options, there is a need to understand the diseas...
| Autor principal: | Soares, Luana da Silva |
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| Outros Autores: | Lima, A. B, Pantoja, K. C, Lobo, Patr?cia dos Santos, Cruz, J. F, Guerra, Sylvia de F?tima dos Santos, Bezerra, D. A. M, Bandeira, R. S, Mascarenhas, Joana D'Arc Pereira |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Cold Spring Harbor Laboratory
2019
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3639 |
| Resumo: |
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Human Bocavirus (HBoV) is a recently discovered virus and was first detected in the
nasopharyngeal aspirate samples and after in stool samples, suggesting that HBoV may
be a causative agent for human enteric infections. Due to absence of treatment options,
there is a need to understand the disease-causing mechanism of these viruses. The aim
of this was to demonstrate the prevalence of HBoV from children less than 10 years
with acute gastroenteritis in Brazil, during November 2011 to November 2012. Stool
samples from hospitalized children ? 10 years who presented symptoms of acute
gastroenteritis were analyzed for the presence of HBoV DNA by nested-PCR. HBoVpositivity was detected in 24.0% (54/225) of samples. Two peaks of HBoV detection
were observed, during November 2011 and July to September 2012. Co-infections
between HBoV and rotavirus A were identified in 50.0% (27/54) of specimens.
Phylogenetic analysis identified the presence of HBoV-1 (94.8%), HBoV-2 (2.6%) and
HBoV-3 (2.6%) species, with only minor variations among them. Further investigations
are necessary to improve the knowledge on the role of HBoV in gastrointestinal
infections. |