Anti-promastigote activity of the amazon plants
This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was evaluated through the cell viability assessment met...
| Autor principal: | Silva-Silva, Jo?o Victor |
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| Outros Autores: | Monteiro, R. C. S., Brigido, H. P. C., Vale, Valdicley Vieira, Silvestre, J. V., Silva, N. C. S., Silveira, Fernando Tobias, Marinho, A. M. R., Dolabela, Maria Fani |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
David Publishing
2019
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3692 |
| Resumo: |
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This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against
promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was
evaluated through the cell viability assessment method (MTT). The ethanol extract, fractions, and isolated substance from Himatanthus
articulatus and Parahancornia fasciculata were inactive in promastigote of L. amazonensis, as the ethanol extract of Physalis angulata.
The hexane fractions from different parts of Montrichardia linifera showed anti-promastigote activity probably due to the presence of
steroids and terpenes. All species in studies were inactive, except of M. linifera. The few polar constituents can be responsible for the activity. Therefore, the isolation and purification of the active on L. amazonensis promastigotes are urgently required. |