Serological and molecular retrospective analysis of hepatitis E suspected cases from the Eastern Brazilian Amazon 1993-2014
Introduction: We evaluated the anti-hepatitis E virus (HEV) antibody prevalence and HEV-RNA in archived serum samples of non-A?C hepatitis, or suspected cases of HEV infection from the Eastern Brazilian Amazon from 1993 to 2014. Methods: Serum samples (n = 318) were tested using ELISA and immunobl...
| Autor principal: | Souza, Alex Junior Souza de |
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| Outros Autores: | Malheiros, Andreza Pinheiro, Sarmento, V?nia Pinto, Resende, Fabricio de Souza, Alves, Max Moreira, Nunes, Heloisa Marceliano, Soares, Manoel do Carmo Pereira, S?, Lilian Rose Marques de |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Sociedade Brasileira de Medicina Tropical
2019
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3717 |
| Resumo: |
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Introduction: We evaluated the anti-hepatitis E virus (HEV) antibody prevalence and HEV-RNA in archived serum samples of
non-A?C hepatitis, or suspected cases of HEV infection from the Eastern Brazilian Amazon from 1993 to 2014. Methods: Serum
samples (n = 318) were tested using ELISA and immunoblotting, and screened for HEV-RNA by RT-qPCR. Results: Anti-HEV
IgM and IgG were detected in 3.4% (11/318) and 5.9% (19/318) of the samples, respectively. All samples were HEV-RNA
negative. Conclusions: HEV was detected at a low prevalence. Broader serological and molecular evaluation of HEV infection
in the Amazon region should be carried out. |