Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
The immunogenicity and protective efficacy of various antigen-adjuvant fomulations derived either from the merezoite-surface protein-3(MSP-3)or the glutamate-richprotein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These Proteins were selected for immunogenicity studi...
| Autor principal: | Carvalho, Leonardo J. de Moura |
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| Outros Autores: | Oliveira, S. G., Theisen, M., Alves, F. A., Andrade, M. C. R., Zanini, G. M., Br?gido, Maria do Carmo de Oliveira, Oeuvray, C., P?voa, Marinete Marins, Muniz, Jos? Augusto Pereira Carneiro, Druilhe, P., Daniel-Ribeiro, Claudio Tadeu |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Wiley
2019
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| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3736 |
| Resumo: |
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The immunogenicity and protective efficacy of various antigen-adjuvant fomulations derived either from the merezoite-surface protein-3(MSP-3)or the glutamate-richprotein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These Proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S.sciureus monkeys immunized with MSP-3 212-380 - AS02 or GLURP 27-500 - alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) stain] blodd-stage infection, and thisprotection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection usig adjuvants that are aceptable for human use and this sholud trigger further studies with those new antigens. |