Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels

Carvalho, Leonardo J. de Moura; Oliveira, S. G.; Theisen, M.; Alves, F. A.; Andrade, M. C. R.; Zanini, G. M.; Br?gido, Maria do Carmo de Oliveira; Oeuvray, C.; P?voa, Marinete Marins; Muniz, Jos? Augusto Pereira Carneiro; Druilhe, P.; Daniel-Ribeiro, Claudio Tadeu

Artigo

Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels

The immunogenicity and protective efficacy of various antigen-adjuvant fomulations derived either from the merezoite-surface protein-3(MSP-3)or the glutamate-richprotein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These Proteins were selected for immunogenicity studi...

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Autor principal:	Carvalho, Leonardo J. de Moura
Outros Autores:	Oliveira, S. G., Theisen, M., Alves, F. A., Andrade, M. C. R., Zanini, G. M., Br?gido, Maria do Carmo de Oliveira, Oeuvray, C., P?voa, Marinete Marins, Muniz, Jos? Augusto Pereira Carneiro, Druilhe, P., Daniel-Ribeiro, Claudio Tadeu
Grau:	Artigo
Idioma:	eng
Publicado em:	Wiley 2019
Assuntos:	Saimiri / imunologia Plasmodium falciparum / imunologia Ant?genos de Protozo?rios Anticorpos Antiprotozo?rios / an?lise
Acesso em linha:	http://patua.iec.gov.br//handle/iec/3736

id	ir-iec-3736
recordtype	dspace
spelling	ir-iec-37362019-06-05T10:59:42Z Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels Carvalho, Leonardo J. de Moura Oliveira, S. G. Theisen, M. Alves, F. A. Andrade, M. C. R. Zanini, G. M. Br?gido, Maria do Carmo de Oliveira Oeuvray, C. P?voa, Marinete Marins Muniz, Jos? Augusto Pereira Carneiro Druilhe, P. Daniel-Ribeiro, Claudio Tadeu Saimiri / imunologia Plasmodium falciparum / imunologia Ant?genos de Protozo?rios Anticorpos Antiprotozo?rios / an?lise The immunogenicity and protective efficacy of various antigen-adjuvant fomulations derived either from the merezoite-surface protein-3(MSP-3)or the glutamate-richprotein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These Proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S.sciureus monkeys immunized with MSP-3 212-380 - AS02 or GLURP 27-500 - alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) stain] blodd-stage infection, and thisprotection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection usig adjuvants that are aceptable for human use and this sholud trigger further studies with those new antigens. 2019-05-31T18:13:12Z 2019-05-31T18:13:12Z 2004 Artigo CARVALHO, L. J. M. et al. Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels. Scandinavian Journal of Immunology, v. 59, n. 4, p. 363-372, Apr. 2004. 0300-9475 http://patua.iec.gov.br//handle/iec/3736 eng Acesso Aberto application/pdf Wiley
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Saimiri / imunologia Plasmodium falciparum / imunologia Ant?genos de Protozo?rios Anticorpos Antiprotozo?rios / an?lise
spellingShingle	Saimiri / imunologia Plasmodium falciparum / imunologia Ant?genos de Protozo?rios Anticorpos Antiprotozo?rios / an?lise Carvalho, Leonardo J. de Moura Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
topic_facet	Saimiri / imunologia Plasmodium falciparum / imunologia Ant?genos de Protozo?rios Anticorpos Antiprotozo?rios / an?lise
description	The immunogenicity and protective efficacy of various antigen-adjuvant fomulations derived either from the merezoite-surface protein-3(MSP-3)or the glutamate-richprotein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These Proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth. Some of the S.sciureus monkeys immunized with MSP-3 212-380 - AS02 or GLURP 27-500 - alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) stain] blodd-stage infection, and thisprotection was related to the prechallenge antibody titres induced. The data are indicative that MSP-3 and GLURP can induce protective immunity against an experimental P. falciparum infection usig adjuvants that are aceptable for human use and this sholud trigger further studies with those new antigens.
format	Artigo
author	Carvalho, Leonardo J. de Moura
author2	Oliveira, S. G. Theisen, M. Alves, F. A. Andrade, M. C. R. Zanini, G. M. Br?gido, Maria do Carmo de Oliveira Oeuvray, C. P?voa, Marinete Marins Muniz, Jos? Augusto Pereira Carneiro Druilhe, P. Daniel-Ribeiro, Claudio Tadeu
author2Str	Oliveira, S. G. Theisen, M. Alves, F. A. Andrade, M. C. R. Zanini, G. M. Br?gido, Maria do Carmo de Oliveira Oeuvray, C. P?voa, Marinete Marins Muniz, Jos? Augusto Pereira Carneiro Druilhe, P. Daniel-Ribeiro, Claudio Tadeu
title	Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title_short	Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title_full	Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title_fullStr	Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title_full_unstemmed	Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
title_sort	immunization of saimiri sciureus monkeys with plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels
publisher	Wiley
publishDate	2019
url	http://patua.iec.gov.br//handle/iec/3736
_version_	1717584510035427328
score	11.755432

Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merezoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels

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