What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil

Silveira, Fernando Tobias

Artigo

What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil

American cutaneous leishmaniasis (ACL) is a parasitic protozoan disease caused by different Leishmania species widely distributed throughout Latin America. Fifteen Leishmania species belonging to the subgenera Viannia, Leishmania and Mundinia are known to cause ACL. Seven of these species are found...

ver descrição completa

Autor principal:	Silveira, Fernando Tobias
Grau:	Artigo
Idioma:	eng
Publicado em:	Oxford University Press 2019
Assuntos:	Leishmaniose Cut?nea / parasitologia Leishmaniose Mucocut?nea / parasitologia Leishmaniose Cut?nea / imunologia Leishmaniose Mucocut?nea / imunologia Pele / les?es Revis?o
Acesso em linha:	http://patua.iec.gov.br//handle/iec/3970

id	ir-iec-3970
recordtype	dspace
spelling	ir-iec-39702019-11-13T17:53:19Z What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil Silveira, Fernando Tobias Leishmaniose Cut?nea / parasitologia Leishmaniose Mucocut?nea / parasitologia Leishmaniose Cut?nea / imunologia Leishmaniose Mucocut?nea / imunologia Pele / les?es Revis?o American cutaneous leishmaniasis (ACL) is a parasitic protozoan disease caused by different Leishmania species widely distributed throughout Latin America. Fifteen Leishmania species belonging to the subgenera Viannia, Leishmania and Mundinia are known to cause ACL. Seven of these species are found in Brazil, of which Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis have the highest potential to cause mucosal (ML) and anergic diffuse cutaneous leishmaniasis (DCL), respectively, the most severe forms of ACL. The clinical and immunopathological differences between these two clinical forms are reviewed here, taking into account their different physiopathogenic mechanisms of dissemination from cutaneous lesions to mucosal tissues in the case of ML and to almost all body surfaces in the case of anergic DCL. We also discuss some immunopathogenic mechanisms of species-specific Leishmania antigens (from the subgenera Viannia and Leishmania) that are most likely associated with the clinical and immunopathological differences between ML and anergic DCL. Those discussions emphasize the pivotal importance of some surface antigens of L. (V.) braziliensis and L. (L.) amazonensis, such as lipophosphoglycan, phosphatidylserine and CD200 (an immunoregulatory molecule that inhibits macrophage activation), that have been shown to exert strong influences on the clinical and immunopathological differences between ML and anergic DCL. 2019-11-12T19:33:50Z 2019-11-12T19:33:50Z 2019 Artigo SILVEIRA, Fernando Tobias. What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 113, n. 9, p. 505-516, Sept. 2019. 1878-3503 http://patua.iec.gov.br//handle/iec/3970 10.1093/trstmh/trz037 eng Acesso Embargado application/pdf Oxford University Press
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Leishmaniose Cut?nea / parasitologia Leishmaniose Mucocut?nea / parasitologia Leishmaniose Cut?nea / imunologia Leishmaniose Mucocut?nea / imunologia Pele / les?es Revis?o
spellingShingle	Leishmaniose Cut?nea / parasitologia Leishmaniose Mucocut?nea / parasitologia Leishmaniose Cut?nea / imunologia Leishmaniose Mucocut?nea / imunologia Pele / les?es Revis?o Silveira, Fernando Tobias What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil
topic_facet	Leishmaniose Cut?nea / parasitologia Leishmaniose Mucocut?nea / parasitologia Leishmaniose Cut?nea / imunologia Leishmaniose Mucocut?nea / imunologia Pele / les?es Revis?o
description	American cutaneous leishmaniasis (ACL) is a parasitic protozoan disease caused by different Leishmania species widely distributed throughout Latin America. Fifteen Leishmania species belonging to the subgenera Viannia, Leishmania and Mundinia are known to cause ACL. Seven of these species are found in Brazil, of which Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis have the highest potential to cause mucosal (ML) and anergic diffuse cutaneous leishmaniasis (DCL), respectively, the most severe forms of ACL. The clinical and immunopathological differences between these two clinical forms are reviewed here, taking into account their different physiopathogenic mechanisms of dissemination from cutaneous lesions to mucosal tissues in the case of ML and to almost all body surfaces in the case of anergic DCL. We also discuss some immunopathogenic mechanisms of species-specific Leishmania antigens (from the subgenera Viannia and Leishmania) that are most likely associated with the clinical and immunopathological differences between ML and anergic DCL. Those discussions emphasize the pivotal importance of some surface antigens of L. (V.) braziliensis and L. (L.) amazonensis, such as lipophosphoglycan, phosphatidylserine and CD200 (an immunoregulatory molecule that inhibits macrophage activation), that have been shown to exert strong influences on the clinical and immunopathological differences between ML and anergic DCL.
format	Artigo
author	Silveira, Fernando Tobias
title	What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil
title_short	What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil
title_full	What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil
title_fullStr	What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil
title_full_unstemmed	What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil
title_sort	what makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? a review in brazil
publisher	Oxford University Press
publishDate	2019
url	http://patua.iec.gov.br//handle/iec/3970
_version_	1717584332059574272
score	11.653393

What makes mucosal and anergic diffuse cutaneous leishmaniases so clinically and immunopathogically different? A review in Brazil

Registros relacionados