Low prevalence of HIV-1 integrase resistance among antiretroviral-naive patients newly diagnosed with HIV-1 from Bel?m, Par?, Amazon region of Brazil
We described the HIV-1 subtypes and the frequency of resistance mutations in HIV-1 integrase region among antiretroviral-naive patients with HIV/AIDS from Bel?m, Par?, Amazon region of Brazil. The partial integrase gene sequence of 59 antiretroviral-naive HIV-1 infected patients was amplified and se...
| Autor principal: | Torres, Maria K. S |
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| Outros Autores: | Avelino, Maria E. S, Irias, Susan F, Barbosa, Mike S, Pereira, Danilo L. A, Lima, Ana B. F, Lemos, Poliana da Silva, Lima, Clayton Pereira Silva de, Oliveira, Renato R. M, Fr?nces, Regiane S. K, Vianez J?nior, Jo?o L?dio da Silva Gon?alves, Machado, Luiz Fernando Almeida |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Mary Ann Liebert
2020
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| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/4053 |
| Resumo: |
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We described the HIV-1 subtypes and the frequency of resistance mutations in HIV-1 integrase region among antiretroviral-naive patients with HIV/AIDS from Bel?m, Par?, Amazon region of Brazil. The partial integrase gene sequence of 59 antiretroviral-naive HIV-1 infected patients was amplified and sequenced. Genotypic analyses revealed the absence of major resistance-associated mutations to integrase but minor polymorphic mutations were present in 44.1% of patients and M50I polymorphism was the more prevalent. |