Genomic and epidemiological surveillance of Zika virus in the Amazon region
Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, littl...
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ir-iec-40672020-03-28T22:10:05Z Genomic and epidemiological surveillance of Zika virus in the Amazon region Giovanetti, Marta Faria, Nuno Rodrigues Louren?o, Jos? Jesus, Jaqueline Goes de Xavier, Joilson Claro, Ingra Morales Kraemer, Moritz U. G Fonseca, Vagner Dellicour, Simon Th?ze, Julien Salles, Flavia da Silva Graf, Tiago Silveira, Paola Paz Nascimento, Valdinete Alves do Souza, Victor Costa de Iani, Felipe Campos de Melo Castilho-Martins, Emerson Augusto Cruz, Laura Nogueira Wallau, Gabriel Fabri, Allison Levy, Fl?via Quick, Joshua Azevedo, Vasco de Aguiar, Renato Santana Oliveira, Tulio de Menezes, Camila B?tto de Castilho, Marcia da Costa Terra, Tirza Matos Silva, Marineide Souza da Filippis, Ana Maria Bispo de Abreu, Andr? Luiz de Oliveira, Wanderson Kleber Croda, Julio Albuquerque, Carlos F. Campelo de Nunes, Marcio Roberto Teixeira Sabino, Ester Cerdeira Loman, Nicholas Naveca, Felipe Gomes Pybus, Oliver G Alcantara, Luiz Carlos Zika virus / patogenicidade Zika virus / isolamento & purifica??o Infec??o por Zika virus / transmiss?o Infec??o por Zika virus / gen?tica Surtos de Doen?as Manaus (AM) Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil. OxfordNanoporeTechnologiesfortechnicalsupportandQIAGENforsupport of the ZIBRA-2 (Zika in Brazil Real Time Analyses-Second Round)project with reagents and equipment. This work was supported by Decit/SCTIE/MoH and CNPq (440685/2016-8 and 440856/2016-7); by CAPES(88887.130716/2016-00, 88881.130825/2016-00, and 88887.130823/2016-00); by the European Union (EU) Horizon 2020 Programme through ZIKAlliance(PRES-005-FEX-17-4-2-33); by the Medical Research Council and FAPESPCADDE partnership award (MR/S0195/1); and by the Oxford Martin School.N.R.F. is supported by a Sir Henry Dale Fellowship (204311/Z/16/Z).M.U.G.K. is supported by The Branco Weiss Fellowship - Society in Science,administered by ETH Zurich, and acknowledges funding from a Google FacultyAward and a Training Grant from the National Institute of Child Health and Hu-man Development (T32HD040128). S.D. is supported by Fonds National de laRecherche Scientifique (FNRS; Belgium). The activities of the A.M.B.F. labora-tory were supported by the Faperj under the grant no. E-26/2002.930/2016, bytheInternational Development Research Centre (IDRC)Canadaunderthe grant108411-001) and the EU Horizon 2020 Programme through ZikaPlan andZikAction (grants 734584 and 734857). M.G. is supported by Fundac ?~ao deAmparo a`Pesquisa do Estado do Rio de Janeiro (FAPERJ) 2020-03-28T18:50:30Z 2020-03-28T18:50:30Z 2020 Artigo GIOVANETTI, Marta et al. Genomic and epidemiological surveillance of Zika virus in the Amazon region. Cell Reports, v. 30, n. 7, p. 2275-2283, Feb. 2020. 2211-1247 http://patua.iec.gov.br//handle/iec/4067 10.1016/j.celrep.2020.01.085 eng Acesso Aberto application/pdf Elsevier |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Zika virus / patogenicidade Zika virus / isolamento & purifica??o Infec??o por Zika virus / transmiss?o Infec??o por Zika virus / gen?tica Surtos de Doen?as Manaus (AM) |
| spellingShingle |
Zika virus / patogenicidade Zika virus / isolamento & purifica??o Infec??o por Zika virus / transmiss?o Infec??o por Zika virus / gen?tica Surtos de Doen?as Manaus (AM) Giovanetti, Marta Genomic and epidemiological surveillance of Zika virus in the Amazon region |
| topic_facet |
Zika virus / patogenicidade Zika virus / isolamento & purifica??o Infec??o por Zika virus / transmiss?o Infec??o por Zika virus / gen?tica Surtos de Doen?as Manaus (AM) |
| description |
Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil. |
| format |
Artigo |
| author |
Giovanetti, Marta |
| author2 |
Faria, Nuno Rodrigues Louren?o, Jos? Jesus, Jaqueline Goes de Xavier, Joilson Claro, Ingra Morales Kraemer, Moritz U. G Fonseca, Vagner Dellicour, Simon Th?ze, Julien Salles, Flavia da Silva Graf, Tiago Silveira, Paola Paz Nascimento, Valdinete Alves do Souza, Victor Costa de Iani, Felipe Campos de Melo Castilho-Martins, Emerson Augusto Cruz, Laura Nogueira Wallau, Gabriel Fabri, Allison Levy, Fl?via Quick, Joshua Azevedo, Vasco de Aguiar, Renato Santana Oliveira, Tulio de Menezes, Camila B?tto de Castilho, Marcia da Costa Terra, Tirza Matos Silva, Marineide Souza da Filippis, Ana Maria Bispo de Abreu, Andr? Luiz de Oliveira, Wanderson Kleber Croda, Julio Albuquerque, Carlos F. Campelo de Nunes, Marcio Roberto Teixeira Sabino, Ester Cerdeira Loman, Nicholas Naveca, Felipe Gomes Pybus, Oliver G Alcantara, Luiz Carlos |
| author2Str |
Faria, Nuno Rodrigues Louren?o, Jos? Jesus, Jaqueline Goes de Xavier, Joilson Claro, Ingra Morales Kraemer, Moritz U. G Fonseca, Vagner Dellicour, Simon Th?ze, Julien Salles, Flavia da Silva Graf, Tiago Silveira, Paola Paz Nascimento, Valdinete Alves do Souza, Victor Costa de Iani, Felipe Campos de Melo Castilho-Martins, Emerson Augusto Cruz, Laura Nogueira Wallau, Gabriel Fabri, Allison Levy, Fl?via Quick, Joshua Azevedo, Vasco de Aguiar, Renato Santana Oliveira, Tulio de Menezes, Camila B?tto de Castilho, Marcia da Costa Terra, Tirza Matos Silva, Marineide Souza da Filippis, Ana Maria Bispo de Abreu, Andr? Luiz de Oliveira, Wanderson Kleber Croda, Julio Albuquerque, Carlos F. Campelo de Nunes, Marcio Roberto Teixeira Sabino, Ester Cerdeira Loman, Nicholas Naveca, Felipe Gomes Pybus, Oliver G Alcantara, Luiz Carlos |
| title |
Genomic and epidemiological surveillance of Zika virus in the Amazon region |
| title_short |
Genomic and epidemiological surveillance of Zika virus in the Amazon region |
| title_full |
Genomic and epidemiological surveillance of Zika virus in the Amazon region |
| title_fullStr |
Genomic and epidemiological surveillance of Zika virus in the Amazon region |
| title_full_unstemmed |
Genomic and epidemiological surveillance of Zika virus in the Amazon region |
| title_sort |
genomic and epidemiological surveillance of zika virus in the amazon region |
| publisher |
Elsevier |
| publishDate |
2020 |
| url |
http://patua.iec.gov.br//handle/iec/4067 |
| _version_ |
1717584332853346304 |
| score |
11.755432 |