Risk of Zika virus-associated birth defects in congenital confirmed cases in the Brazilian Amazon
Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during pregnancy. Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Par...
| Autor principal: | Oliveira, Consuelo Silva de |
|---|---|
| Outros Autores: | Matos, Haroldo Jos? de, Ramos, Francisco L?zio de Paula, Pinto, Ana Yec? das Neves, Graim, Priscila Nathyelly dos S, Guimar?es, Vivianne de Paula R, Gomes, Luna Tha?s S, Serra, Emilene M. F, Cruz, Ana Cec?lia Ribeiro, Leal, Alessandra, Henriques, Daniele Freitas, Lima, Juliana A, Anjos, Maura V, Pinto, Eliana Vieira Pinto da, Souza, Alana W. de, Vasconcelos, Pedro Fernando da Costa |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Pan American Health Organization
2020
|
| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/4177 |
| Resumo: |
|---|
|
Objective. To establish the risk of microcephaly in neonates born to women infected with ZIKV during
pregnancy.
Methods. A cohort of laboratory-confirmed ZIKV cases of congenital infections (109 mothers infected during
pregnancy and 101 newborns) among 308 suspect cases was followed in Belem, Par?, Brazil, from October
2015 to December 2017.
Results. A microcephaly risk of 1.98% (95% CI 0.54-6.93%) was found, or 2 cases among the 101 neonates
infected with ZIKV during pregnancy. 72% of the pregnant women had ZIKV infection confirmed by RT-qPCR
during gestation.
Conclusions. Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage,
which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/
or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection. |