Artigo

Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?

Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microar...

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Autor principal: Almeida, Deise Cibele N. de
Outros Autores: Souza, Michel Platini Caldas de, Amorim, Carolina Koury Nassar, Mau?s, Jersey Heitor da Silva, Sagica, Fernanda do Espirito Santo, Moreira-Nunes, Caroline Aquino, Oliveria, Edivaldo Herculano Corr?a de
Grau: Artigo
Idioma: eng
Publicado em: International Institute of Anticancer Research 2020
Assuntos:
Neoplasias / diagn?stico
Neoplasias da Gl?ndula Tireoide / diagn?stico
C?ncer Papil?fero da Tireoide
Estresse Oxidativo / gen?tica
Idoso / fisiologia
Envelhecimento
Acesso em linha: http://patua.iec.gov.br//handle/iec/4170
id ir-iec-4170
recordtype dspace
spelling ir-iec-41702020-09-15T17:23:27Z Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses? Almeida, Deise Cibele N. de Souza, Michel Platini Caldas de Amorim, Carolina Koury Nassar Mau?s, Jersey Heitor da Silva Sagica, Fernanda do Espirito Santo Moreira-Nunes, Caroline Aquino Oliveria, Edivaldo Herculano Corr?a de Neoplasias / diagn?stico Neoplasias da Gl?ndula Tireoide / diagn?stico C?ncer Papil?fero da Tireoide Estresse Oxidativo / gen?tica Idoso / fisiologia Envelhecimento Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ?45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age. Patients and Methods: In order to search and compare genomic alterations that may be related to age, we evaluated the occurrence of CNAs in the genome of 24 PTC samples, divided in two groups (<45 and ?45 years old). Results: We identified only one region showing a statistically significant difference between the groups (p=0.00357): a deletion of approximately 537 kps in 1p35.3., which was more frequent in patients aged 45 years or older. This is the region where, among others, the gene SESN2 is located, which is activated under oxidative stress and plays an antioxidant role, in addition to protecting the genetic material from damage generated by reactive oxygen species (ROS). Conclusion: This is the first time that a CNA involving the deletion of the SESN2 gene is associated with papillary thyroid carcinomas, particularly in patients aged 45 years and older, indicating that this deletion would lead to a more malignant and prominent tumoral behavior associated to a worst prognosis. This study was partially supported by the Ministry of Health through the Evandro Chagas Institute official budget and by CNPq (process 307382/2019-2) 2020-09-15T16:15:22Z 2020-09-15T16:15:22Z 2020 Artigo ALMEIDA, Deise Cibele N. de et al. Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?. Cancer Genomics and Proteomics, v. 17, n. 5, p. 643-648, Sept./Oct. 2020. 1790-6245 http://patua.iec.gov.br//handle/iec/4170 10.21873/cgp.20220 eng Acesso Aberto application/pdf International Institute of Anticancer Research
institution Instituto Evandro Chagas (IEC)
collection PATUA
language eng
topic Neoplasias / diagn?stico
Neoplasias da Gl?ndula Tireoide / diagn?stico
C?ncer Papil?fero da Tireoide
Estresse Oxidativo / gen?tica
Idoso / fisiologia
Envelhecimento
spellingShingle Neoplasias / diagn?stico
Neoplasias da Gl?ndula Tireoide / diagn?stico
C?ncer Papil?fero da Tireoide
Estresse Oxidativo / gen?tica
Idoso / fisiologia
Envelhecimento
Almeida, Deise Cibele N. de
Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?
topic_facet Neoplasias / diagn?stico
Neoplasias da Gl?ndula Tireoide / diagn?stico
C?ncer Papil?fero da Tireoide
Estresse Oxidativo / gen?tica
Idoso / fisiologia
Envelhecimento
description Background/Aim: Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ?45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age. Patients and Methods: In order to search and compare genomic alterations that may be related to age, we evaluated the occurrence of CNAs in the genome of 24 PTC samples, divided in two groups (<45 and ?45 years old). Results: We identified only one region showing a statistically significant difference between the groups (p=0.00357): a deletion of approximately 537 kps in 1p35.3., which was more frequent in patients aged 45 years or older. This is the region where, among others, the gene SESN2 is located, which is activated under oxidative stress and plays an antioxidant role, in addition to protecting the genetic material from damage generated by reactive oxygen species (ROS). Conclusion: This is the first time that a CNA involving the deletion of the SESN2 gene is associated with papillary thyroid carcinomas, particularly in patients aged 45 years and older, indicating that this deletion would lead to a more malignant and prominent tumoral behavior associated to a worst prognosis.
format Artigo
author Almeida, Deise Cibele N. de
author2 Souza, Michel Platini Caldas de
Amorim, Carolina Koury Nassar
Mau?s, Jersey Heitor da Silva
Sagica, Fernanda do Espirito Santo
Moreira-Nunes, Caroline Aquino
Oliveria, Edivaldo Herculano Corr?a de
author2Str Souza, Michel Platini Caldas de
Amorim, Carolina Koury Nassar
Mau?s, Jersey Heitor da Silva
Sagica, Fernanda do Espirito Santo
Moreira-Nunes, Caroline Aquino
Oliveria, Edivaldo Herculano Corr?a de
title Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?
title_short Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?
title_full Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?
title_fullStr Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?
title_full_unstemmed Copy number alterations in papillary thyroid carcinomas: does loss of SESN2 have a role in age-related different prognoses?
title_sort copy number alterations in papillary thyroid carcinomas: does loss of sesn2 have a role in age-related different prognoses?
publisher International Institute of Anticancer Research
publishDate 2020
url http://patua.iec.gov.br//handle/iec/4170
_version_ 1717584538549354496
score 11.755432

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