First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil
Abstract: Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in t...
| Autor principal: | Santos, Anderson Lineu Siqueira dos |
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| Outros Autores: | Rodrigues, Yan Corr?a, Melo, Marcos Vin?cios Hino de, Santos, Pabllo Antonny Silva dos, Oliveira, Tatyellen Natasha da Costa, Sardinha, Daniele Melo, Lima, Luana Nepomuceno Gondim Costa, Brasiliense, Danielle Murici, Lima, Karla Val?ria Batista |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/4221 |
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ir-iec-4221 |
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ir-iec-42212021-01-26T12:41:55Z First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil Santos, Anderson Lineu Siqueira dos Rodrigues, Yan Corr?a Melo, Marcos Vin?cios Hino de Santos, Pabllo Antonny Silva dos Oliveira, Tatyellen Natasha da Costa Sardinha, Daniele Melo Lima, Luana Nepomuceno Gondim Costa Brasiliense, Danielle Murici Lima, Karla Val?ria Batista Neoplasias / patologia Klebsiella pneumoniae / patogenicidade Infec??es por Klebsiella / microbiologia Resist?ncia a M?ltiplos Medicamentos Abstract: Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of Par?, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital admission. K. pneumoniae isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including two colistin-resistant isolates and seven isolates harboring blaKPC-1 gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Par?, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of K. pneumoniae in the region. This research was supported by funding from the Funda??o de Amparo ? Pesquisa do Par?/Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (FAPESPA/CAPES) [Cooperation grant N?017/2014], Programa Institucional de Bolsas de Inicia??o Cient?fica/Funda??o Amaz?nia Paraense de Amparo ? Pesquisa/Universidade do Estado do Par? (FAPESPA/UEPA) [Cooperation grant N?001/2017/PPGBPA], Funda??o de Amparo ? Pesquisa do Par?/Universidade do Estado do Par? (FAPESPA/UEPA) [Cooperation grant N?004/2019] and the Instituto Evandro Chagas/Minist?rio da Sa?de/Secretaria de Vigil?ncia em Sa?de (IEC/MS/SVS) 2021-01-26T12:22:00Z 2021-01-26T12:22:00Z 2020 Artigo SANTOS, Anderson Lineu Siqueira dos et al. First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil. Infectious Disease Reports, v. 12, n. 3, p. 110-120, Dec. 2020. 2036-7449 http://patua.iec.gov.br//handle/iec/4221 10.3390/idr12030021 eng Acesso Aberto application/pdf MDPI |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Neoplasias / patologia Klebsiella pneumoniae / patogenicidade Infec??es por Klebsiella / microbiologia Resist?ncia a M?ltiplos Medicamentos |
| spellingShingle |
Neoplasias / patologia Klebsiella pneumoniae / patogenicidade Infec??es por Klebsiella / microbiologia Resist?ncia a M?ltiplos Medicamentos Santos, Anderson Lineu Siqueira dos First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil |
| topic_facet |
Neoplasias / patologia Klebsiella pneumoniae / patogenicidade Infec??es por Klebsiella / microbiologia Resist?ncia a M?ltiplos Medicamentos |
| description |
Abstract: Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to
infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state
of Par?, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational,
cross-sectional study, with a descriptive and analytical approach was conducted, including patients
with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital
admission. K. pneumoniae isolates included in the study were obtained from different clinical materials
(blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical
wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding
genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including
two colistin-resistant isolates and seven isolates harboring blaKPC-1 gene. To conclude, our findings
provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Par?,
Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread
of resistance strains of K. pneumoniae in the region. |
| format |
Artigo |
| author |
Santos, Anderson Lineu Siqueira dos |
| author2 |
Rodrigues, Yan Corr?a Melo, Marcos Vin?cios Hino de Santos, Pabllo Antonny Silva dos Oliveira, Tatyellen Natasha da Costa Sardinha, Daniele Melo Lima, Luana Nepomuceno Gondim Costa Brasiliense, Danielle Murici Lima, Karla Val?ria Batista |
| author2Str |
Rodrigues, Yan Corr?a Melo, Marcos Vin?cios Hino de Santos, Pabllo Antonny Silva dos Oliveira, Tatyellen Natasha da Costa Sardinha, Daniele Melo Lima, Luana Nepomuceno Gondim Costa Brasiliense, Danielle Murici Lima, Karla Val?ria Batista |
| title |
First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil |
| title_short |
First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil |
| title_full |
First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil |
| title_fullStr |
First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil |
| title_full_unstemmed |
First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil |
| title_sort |
first insights into clinical and resistance features of infections by klebsiella pneumoniae among oncological patients from a referral center in amazon region, brazil |
| publisher |
MDPI |
| publishDate |
2021 |
| url |
http://patua.iec.gov.br//handle/iec/4221 |
| _version_ |
1717584539666087936 |
| score |
11.755432 |