Layered double hydroxide?indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases
Indomethacin (INDO) demonstrates therapeutic efficacy in the treatment of neuroinflammatory diseases. Despite its importance as a drug, INDO causes gastrointestinal problems and adverse reactions in the central nervous system (CNS). In this study, we prepared nanoparticles of layered double hydroxid...
| Autor principal: | Meneses, Carla Carolina Ferreira |
|---|---|
| Outros Autores: | Sousa, Paulo Robson Monteiro, Pinto, Laine Celestino, Coelho, Gerson Maciel, Silva, Tamires Ferreira da, Ferreira, Luan Oliveira, Gustavo, Kayo Silva, Martins-Filho, Arnaldo Jorge, Faial, Kelson do Carmo Freitas, Yamada, Elizabeth Sumi, Lameira, Jer?nimo, Jouin, Jenny, Thomas, Philippe, Masson, Oliver, Lopes, Dielly Catrina Favacho, Alves, Cl?udio Nahum |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Elsevier
2021
|
| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/4224 |
| id |
ir-iec-4224 |
|---|---|
| recordtype |
dspace |
| spelling |
ir-iec-42242021-01-26T17:01:05Z Layered double hydroxide?indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases Meneses, Carla Carolina Ferreira Sousa, Paulo Robson Monteiro Pinto, Laine Celestino Coelho, Gerson Maciel Silva, Tamires Ferreira da Ferreira, Luan Oliveira Gustavo, Kayo Silva Martins-Filho, Arnaldo Jorge Faial, Kelson do Carmo Freitas Yamada, Elizabeth Sumi Lameira, Jer?nimo Jouin, Jenny Thomas, Philippe Masson, Oliver Lopes, Dielly Catrina Favacho Alves, Cl?udio Nahum Sistema Nervoso Central Indometacina / administra??o & dosagem Indomethacin (INDO) demonstrates therapeutic efficacy in the treatment of neuroinflammatory diseases. Despite its importance as a drug, INDO causes gastrointestinal problems and adverse reactions in the central nervous system (CNS). In this study, we prepared nanoparticles of layered double hydroxide (LDH) loaded with INDO. The structure of the nanohybrid (LDH-INDO) was synthesized via a coprecipitation method, and the nanohybrid was characterized using X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis?differential scanning colorimetry (TGA?DSC), field-emission scanning electron microscopy (FE-SEM), and ultraviolet (UV)?vis spectroscopy. Moreover, the drug release profiles of the nanohybrid were investigated using kinetic models. INDO was incorporated within the LDH interlayer space with 50% intercalation. The release of INDO anions from LDH-INDO after 10?h was 90% at pH 4.8???0.02 and 51% at pH 7.4???0.02. The results show that the release profiles follow a pseudo-second-order model. In addition, lipopolysaccharide (LPS)-induced sickness behavior in animals and treatment with INDO and LDH-INDO suggest recovery of the variables (weight and food intake) used in this study. LDH-INDO did not alter hepatic and renal biomarkers. Moreover, LPS increased the number of Iba1+ cells (microgliosis) and caused morphological alterations in these cells in the hippocampus and somatosensory cortex. However, the LPS effect was attenuated after treatment with INDO, both free and LDH-intercalated, in both regions of the brain. 2021-01-26T14:12:52Z 2021-01-26T14:12:52Z 2020 Artigo MENESES, Carla Carolina Ferreira et al. Layered double hydroxide?indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases. Journal of Drug Delivery Science and Technology, v. xx, 102190, p. xx, Oct. 2020 1773-2247 http://patua.iec.gov.br//handle/iec/4224 10.1016/j.jddst.2020.102190 eng Acesso Embargado application/pdf Elsevier |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Sistema Nervoso Central Indometacina / administra??o & dosagem |
| spellingShingle |
Sistema Nervoso Central Indometacina / administra??o & dosagem Meneses, Carla Carolina Ferreira Layered double hydroxide?indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases |
| topic_facet |
Sistema Nervoso Central Indometacina / administra??o & dosagem |
| description |
Indomethacin (INDO) demonstrates therapeutic efficacy in the treatment of neuroinflammatory diseases. Despite its importance as a drug, INDO causes gastrointestinal problems and adverse reactions in the central nervous system (CNS). In this study, we prepared nanoparticles of layered double hydroxide (LDH) loaded with INDO. The structure of the nanohybrid (LDH-INDO) was synthesized via a coprecipitation method, and the nanohybrid was characterized using X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis?differential scanning colorimetry (TGA?DSC), field-emission scanning electron microscopy (FE-SEM), and ultraviolet (UV)?vis spectroscopy. Moreover, the drug release profiles of the nanohybrid were investigated using kinetic models. INDO was incorporated within the LDH interlayer space with 50% intercalation. The release of INDO anions from LDH-INDO after 10?h was 90% at pH 4.8???0.02 and 51% at pH 7.4???0.02. The results show that the release profiles follow a pseudo-second-order model. In addition, lipopolysaccharide (LPS)-induced sickness behavior in animals and treatment with INDO and LDH-INDO suggest recovery of the variables (weight and food intake) used in this study. LDH-INDO did not alter hepatic and renal biomarkers. Moreover, LPS increased the number of Iba1+ cells (microgliosis) and caused morphological alterations in these cells in the hippocampus and somatosensory cortex. However, the LPS effect was attenuated after treatment with INDO, both free and LDH-intercalated, in both regions of the brain. |
| format |
Artigo |
| author |
Meneses, Carla Carolina Ferreira |
| author2 |
Sousa, Paulo Robson Monteiro Pinto, Laine Celestino Coelho, Gerson Maciel Silva, Tamires Ferreira da Ferreira, Luan Oliveira Gustavo, Kayo Silva Martins-Filho, Arnaldo Jorge Faial, Kelson do Carmo Freitas Yamada, Elizabeth Sumi Lameira, Jer?nimo Jouin, Jenny Thomas, Philippe Masson, Oliver Lopes, Dielly Catrina Favacho Alves, Cl?udio Nahum |
| author2Str |
Sousa, Paulo Robson Monteiro Pinto, Laine Celestino Coelho, Gerson Maciel Silva, Tamires Ferreira da Ferreira, Luan Oliveira Gustavo, Kayo Silva Martins-Filho, Arnaldo Jorge Faial, Kelson do Carmo Freitas Yamada, Elizabeth Sumi Lameira, Jer?nimo Jouin, Jenny Thomas, Philippe Masson, Oliver Lopes, Dielly Catrina Favacho Alves, Cl?udio Nahum |
| title |
Layered double hydroxide?indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases |
| title_short |
Layered double hydroxide?indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases |
| title_full |
Layered double hydroxide?indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases |
| title_fullStr |
Layered double hydroxide?indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases |
| title_full_unstemmed |
Layered double hydroxide?indomethacin hybrid: A promising biocompatible compound for the treatment of neuroinflammatory diseases |
| title_sort |
layered double hydroxide?indomethacin hybrid: a promising biocompatible compound for the treatment of neuroinflammatory diseases |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
http://patua.iec.gov.br//handle/iec/4224 |
| _version_ |
1717584354896510976 |
| score |
11.755432 |