Prenatal disorders and congenital Zika syndrome in squirrel monkeys
During the Zika virus (ZIKV) outbreak in Brazil (2015?2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this study, we evaluated the prenatal conditions of pregnant female squirrel monkeys...
| Autor principal: | Imbeloni, Aline Amaral |
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| Outros Autores: | Alcantara, Bianca Nascimento de, Coutinho, Leandro Nassar, Scalercio, Sarah Raphaella Rocha de Azevedo, Carneiro, Liliane Almeida, Oliveira, Karol Guimar?es, Martins Filho, Arnaldo Jorge, Durans, Darlene de Brito Simith, Silva, Wellington Bandeira da, Nunes, Bruno Tardelli Diniz, Casseb, Livia Medeiros Neves, Chiang, Jannifer Oliveira, Carvalho, Carlos Alberto Marques de, Machado, Mariana Borges, Quaresma, Juarez Ant?nio Sim?es, Medeiros, Daniele Barbosa de Almeida, Vasconcelos, Pedro Fernando da Costa |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Nature Research
2021
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| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/4248 |
| Resumo: |
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During the Zika virus (ZIKV) outbreak in Brazil (2015?2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this study, we evaluated the prenatal conditions of pregnant female squirrel monkeys (Saimiri collinsi) infected during different gestational thirds (GTs) and assessed all clinical aspects, diagnostic imaging, viremia and the immune response. In our study, 75% of the infected animals in the 1st GT group had significant clinical manifestations, such as miscarriage and prolonged viremia associated with a late immune response. Consequently, their neonates showed fetal neuropathology, such as cerebral hemorrhage, lissencephaly or malformations of the brain grooves, ventriculomegaly, and craniofacial malformations. Thus, our study demonstrated the relevance of pregnant squirrel monkeys as a model for the study of ZIKV infection in neonates due to the broad clinical manifestations presented, including the typical congenital Zika syndrome manifestations described in humans. |