In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been proposed as ZIKV congenital syndrome. This study aimed to investigate the in situ...
| Autor principal: | Azevedo, Raimunda do Socorro da Silva |
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| Outros Autores: | Sousa, Jorge R. de, Ara?jo, Marialva Tereza Ferreira de, Martins Filho, Arnaldo J, Alcantara, Bianca Nascimento de, Araujo, Fernanda M. C, Queiroz, Maria G. L., Cruz, Ana Cec?lia Ribeiro, Vasconcelos, Beatriz H Baldez, Chiang, Jannifer Oliveira, Martins, L?via Caricio, Casseb, Livia Medeiros Neves, Silva, Eliana Vieira Pinto da, Carvalho, Val?ria Lima, Vasconcelos, Barbara C. Baldez, Rodrigues, Sueli Guerreiro, Oliveira, Consuelo Silva de, Quaresma, Juarez A. S, Vasconcelos, Pedro Fernando da Costa |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Nature Publishing Group
2018
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| Assuntos: | |
| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/3058 |
| Resumo: |
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Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant
women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which
now has been proposed as ZIKV congenital syndrome. This study aimed to investigate the in situ
immune response profle and mechanisms of neuronal cell damage in fatal Zika microcephaly cases.
Brain tissue samples were collected from 15 cases, including 10 microcephalic ZIKV-positive neonates
with fatal outcome and fve neonatal control favivirus-negative neonates that died due to other
causes, but with preserved central nervous system (CNS) architecture. In microcephaly cases, the
histopathological features of the tissue samples were characterized in three CNS areas (meninges,
perivascular space, and parenchyma). The changes found were mainly calcifcation, necrosis,
neuronophagy, gliosis, microglial nodules, and infammatory infltration of mononuclear cells. The
in situ immune response against ZIKV in the CNS of newborns is complex. Despite the predominant
expression of Th2 cytokines, other cytokines such as Th1, Th17, Treg, Th9, and Th22 are involved to a
lesser extent, but are still likely to participate in the immunopathogenic mechanisms of neural disease
in fatal cases of microcephaly caused by ZIKV. |