Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil
A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe around late February 2020. Here we investigated in more detail the origin of the major and most widely disseminated SA...
| Autor principal: | Resende, Paola Cristina |
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| Outros Autores: | Delatorre, Edson, Graf, Tiago, Mir, Daiana, Motta, Fernando Couto, Appolinario, Luciana Reis, Paix?o, Anna Carolina Dias da, Mendon?a, Ana Carolina da Fonseca, Ogrzewalska, Maria, Caetano, Braulia, Wallau, Gabriel Luz, Docena, C?ssio, Santos, Mirleide Cordeiro dos, Ferreira, Jessylene de Almeida, Sousa J?nior, Edivaldo Costa, Silva, Sandro Patroca da, Fernandes, Sandra Bianchini, Vianna, Lucas Alves, Souza, Larissa da Costa, Ferro, Jean F. G, Nardy, Vanessa B, Santos, Cliomar A, Riediger, Irina, Debur, Maria do Carmo, Croda, J?lio, Oliveira, Wanderson Kleber, Abreu, Andr?, Bello, Gonzalo, Siqueira, Marilda M |
| Grau: | Artigo |
| Idioma: | eng |
| Publicado em: |
Frontiers Media
2021
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| Acesso em linha: |
http://patua.iec.gov.br//handle/iec/4264 |
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ir-iec-4264 |
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ir-iec-42642021-03-16T13:06:03Z Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil Resende, Paola Cristina Delatorre, Edson Graf, Tiago Mir, Daiana Motta, Fernando Couto Appolinario, Luciana Reis Paix?o, Anna Carolina Dias da Mendon?a, Ana Carolina da Fonseca Ogrzewalska, Maria Caetano, Braulia Wallau, Gabriel Luz Docena, C?ssio Santos, Mirleide Cordeiro dos Ferreira, Jessylene de Almeida Sousa J?nior, Edivaldo Costa Silva, Sandro Patroca da Fernandes, Sandra Bianchini Vianna, Lucas Alves Souza, Larissa da Costa Ferro, Jean F. G Nardy, Vanessa B Santos, Cliomar A Riediger, Irina Debur, Maria do Carmo Croda, J?lio Oliveira, Wanderson Kleber Abreu, Andr? Bello, Gonzalo Siqueira, Marilda M V?rus da SARS / patogenicidade S?ndrome Respirat?ria Aguda Grave / patologia Infec??es por Coronavirus Muta??o / gen?tica Epidemias Linhagem A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe around late February 2020. Here we investigated in more detail the origin of the major and most widely disseminated SARS-CoV-2 Brazilian lineage B.1.1.33. We recovered 190 whole viral genomes collected from 13 Brazilian states from February 29 to April 31, 2020 and combined them with other B.1.1 genomes collected globally. Our genomic survey confirms that lineage B.1.1.33 is responsible for a variable fraction of the community viral transmissions in Brazilian states, ranging from 2% of all SARS-CoV-2 genomes from Pernambuco to 80% of those from Rio de Janeiro. We detected a moderate prevalence (5-18%) of lineage B.1.1.33 in some South American countries and a very low prevalence (<1%) in North America, Europe, and Oceania. Our study reveals that lineage B.1.1.33 evolved from an ancestral clade, here designated B.1.1.33-like, that carries one of the two B.1.1.33 synapomorphic mutations. The B.1.1.33-like lineage may have been introduced from Europe or arose in Brazil in early February 2020 and a few weeks later gave origin to the lineage B.1.1.33. These SARS-CoV-2 lineages probably circulated during February 2020 and reached all Brazilian regions and multiple countries around the world by mid-March, before the implementation of air travel restrictions in Brazil. Our phylodynamic analysis also indicates that public health interventions were partially effective to control the expansion of lineage B.1.1.33 in Rio de Janeiro because its median effective reproductive number (R e ) was drastically reduced by about 66% during March 2020, but failed to bring it to below one. Continuous genomic surveillance of lineage B.1.1.33 might provide valuable information about epidemic dynamics and the effectiveness of public health interventions in some Brazilian states. We would like to thank the funding support from CGLab/MoH (General Laboratories Coordination of Brazilian Ministry of Health), CVSLR/FIOCRUZ (Coordination of Health Surveillance and Reference Laboratories of Oswaldo Cruz Foundation), CNPq COVID-19 MCTI 402457/2020-0, and INOVA VPPCB-005-FIO20-2 2021-03-16T00:21:23Z 2021-03-16T00:21:23Z 2021 Artigo RESENDE, Paola Cristina et al. Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil. Frontiers in Microbiology, v. 11, n. 615280, Feb. 2021. 1664-302X http://patua.iec.gov.br//handle/iec/4264 10.3389/fmicb.2020.615280 eng Acesso Aberto application/pdf Frontiers Media |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
V?rus da SARS / patogenicidade S?ndrome Respirat?ria Aguda Grave / patologia Infec??es por Coronavirus Muta??o / gen?tica Epidemias Linhagem |
| spellingShingle |
V?rus da SARS / patogenicidade S?ndrome Respirat?ria Aguda Grave / patologia Infec??es por Coronavirus Muta??o / gen?tica Epidemias Linhagem Resende, Paola Cristina Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil |
| topic_facet |
V?rus da SARS / patogenicidade S?ndrome Respirat?ria Aguda Grave / patologia Infec??es por Coronavirus Muta??o / gen?tica Epidemias Linhagem |
| description |
A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe around late February 2020. Here we investigated in more detail the origin of the major and most widely disseminated SARS-CoV-2 Brazilian lineage B.1.1.33. We recovered 190 whole viral genomes collected from 13 Brazilian states from February 29 to April 31, 2020 and combined them with other B.1.1 genomes collected globally. Our genomic survey confirms that lineage B.1.1.33 is responsible for a variable fraction of the community viral transmissions in Brazilian states, ranging from 2% of all SARS-CoV-2 genomes from Pernambuco to 80% of those from Rio de Janeiro. We detected a moderate prevalence (5-18%) of lineage B.1.1.33 in some South American countries and a very low prevalence (<1%) in North America, Europe, and Oceania. Our study reveals that lineage B.1.1.33 evolved from an ancestral clade, here designated B.1.1.33-like, that carries one of the two B.1.1.33 synapomorphic mutations. The B.1.1.33-like lineage may have been introduced from Europe or arose in Brazil in early February 2020 and a few weeks later gave origin to the lineage B.1.1.33. These SARS-CoV-2 lineages probably circulated during February 2020 and reached all Brazilian regions and multiple countries around the world by mid-March, before the implementation of air travel restrictions in Brazil. Our phylodynamic analysis also indicates that public health interventions were partially effective to control the expansion of lineage B.1.1.33 in Rio de Janeiro because its median effective reproductive number (R e ) was drastically reduced by about 66% during March 2020, but failed to bring it to below one. Continuous genomic surveillance of lineage B.1.1.33 might provide valuable information about epidemic dynamics and the effectiveness of public health interventions in some Brazilian states. |
| format |
Artigo |
| author |
Resende, Paola Cristina |
| author2 |
Delatorre, Edson Graf, Tiago Mir, Daiana Motta, Fernando Couto Appolinario, Luciana Reis Paix?o, Anna Carolina Dias da Mendon?a, Ana Carolina da Fonseca Ogrzewalska, Maria Caetano, Braulia Wallau, Gabriel Luz Docena, C?ssio Santos, Mirleide Cordeiro dos Ferreira, Jessylene de Almeida Sousa J?nior, Edivaldo Costa Silva, Sandro Patroca da Fernandes, Sandra Bianchini Vianna, Lucas Alves Souza, Larissa da Costa Ferro, Jean F. G Nardy, Vanessa B Santos, Cliomar A Riediger, Irina Debur, Maria do Carmo Croda, J?lio Oliveira, Wanderson Kleber Abreu, Andr? Bello, Gonzalo Siqueira, Marilda M |
| author2Str |
Delatorre, Edson Graf, Tiago Mir, Daiana Motta, Fernando Couto Appolinario, Luciana Reis Paix?o, Anna Carolina Dias da Mendon?a, Ana Carolina da Fonseca Ogrzewalska, Maria Caetano, Braulia Wallau, Gabriel Luz Docena, C?ssio Santos, Mirleide Cordeiro dos Ferreira, Jessylene de Almeida Sousa J?nior, Edivaldo Costa Silva, Sandro Patroca da Fernandes, Sandra Bianchini Vianna, Lucas Alves Souza, Larissa da Costa Ferro, Jean F. G Nardy, Vanessa B Santos, Cliomar A Riediger, Irina Debur, Maria do Carmo Croda, J?lio Oliveira, Wanderson Kleber Abreu, Andr? Bello, Gonzalo Siqueira, Marilda M |
| title |
Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil |
| title_short |
Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil |
| title_full |
Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil |
| title_fullStr |
Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil |
| title_full_unstemmed |
Evolutionary dynamics and dissemination pattern of the SARS-CoV-2 lineage B.1.1.33 during the early pandemic phase in Brazil |
| title_sort |
evolutionary dynamics and dissemination pattern of the sars-cov-2 lineage b.1.1.33 during the early pandemic phase in brazil |
| publisher |
Frontiers Media |
| publishDate |
2021 |
| url |
http://patua.iec.gov.br//handle/iec/4264 |
| _version_ |
1717584519122386944 |
| score |
11.653393 |