Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy
Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of...
| id |
ir-iec-4310 |
|---|---|
| recordtype |
dspace |
| spelling |
ir-iec-43102021-05-24T15:34:32Z Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy Alecrim, Maria das Gra?as Costa Amorim, Melania Maria Ramos de Ara?jo, Thalia Velho Barreto de Brasil, Patr?cia Brickley, Elizabeth B Castilho, Marcia da Costa Coelho, Bernadete Perez Cunha, Ant?nio Jos? Ledo Alves da Duarte, Geraldo Estofolete, C?ssia Fernanda Gurgel, Ricardo Queiroz Herrero-Silva, Juliana Hofer, Cristina Barroso Lopes, Aline Siqueira Alves Martelli, Celina Maria Turchi Melo, Adriana Suely de Oliveira Miranda Filho, Dem?crito de Barros Montarroyos, Ulisses Ramos Moreira, Maria Elisabeth Mussi-Pinhata, Marisa Marcia Oliveira, Consuelo Silva de Passos, Saulo Duarte Prata-Barbosa, Arnaldo Santos, Darci Neves dos Schuler-Faccini, Lav?nia Silva, Ant?nio Augusto Moura da Siqueira, Isadora Cristina de Sousa, Patr?cia da Silva Turchi, Mar?lia Dalva Ximenes, Ricardo Arraes de Alencar Zara, Ana Laura de Sene Am?ncio Zika virus / patogenicidade Infec??o por Zika virus / gen?tica Microcefalia Gestantes Exantema Metan?lise em Rede Estudos de Coortes Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions. National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico? CNPq) (grant number 404861/2018-0); Wellcome Trust and the United Kingdom?s Department for International Development (grant numbers: 205377/Z/16/Z; 201870/Z/16/Z). European Union?s Horizon 2020 research and innovation programme under ZikaPLAN (grant number 734584). Wellcome Trust - Research Enrichment in Epidemic Situation (grant number 107779/Z/15/Z; with ER1505 & ER1601). Medical Research Council on behalf of the Newton Fund and Wellcome Trust (grant number MC_PC_15088). National Institutes of Health/National Institute of Allergy and Infectious Diseases (grant number RO1/AI140718). Fondation Christophe et Rodolphe M?rieux. National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico?CNPq) (grant numbers 443875/2018-9; 440573/2016-5; 441098/2016-9; 305090/2016-0; 307282/2017-1; 304476/2018- 8; 465549/2014-4; 440763/2016-9; 309722/2017-9; 306708/2014-0; 440577/2016-0). Coordination for the improvement of Higher Education Personnel (Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior-Capes) (grant numbers 88881.130813/2016-01; 88887.116627/2016-01; 88887.136366/2017-00). Ministry of Health of Brazil-Emergency Response in Public Health-Zika virus and Microcephaly (Minist?rio da Sa?de de Brasil-Resposta ? Emerg?ncia em Sa?de P?blica?Zika v?rus e Microcefalia) (grant number 837058/2016). Department of Science and Technology (Departamento de Ci?ncia e TecnologiaDECIT) (grant numbers 25000.072811/2016-19; 440839/2016-5). Foundation of Research Support of the State of S?o Paulo (Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo?FAPESP) (grant numbers 2016/08578-0; 2017/21688-1; 2013/21719-3; 2016/15021-1; 2015/12295-0; 2016/05115-9). Foundation of Research Support of the State of Rio de Janeiro (Funda??o de Amparo ? Pesquisa do Estado do Rio de Janeiro ?FAPERJ) (grant numbers E-26/201.351/2016; E-18/2015TXB; E-26/202.862/2018; E-26/010.002477/2016). Foundation of Support for Research and Scientific and Technological Development of Maranh?o (Funda??o de Amparo ? Pesquisa e ao Desenvolvimento Cient?fico e Tecnol?gico do Maranh?o?FAPEMA) (grant number 008/2016). Brazilian Ministry of Health (Minist?rio da Sa?de?MS) (grant number 929698560001160-02). Evandro Chagas Institute/Brazilian Ministry of Health (Instituto Evandro Chagas/Minist?rio da Sa?de). Foundation of Research Support of the State of Goi?s (Funda??o de Amparo ? Pesquisa do Estado de Goi?s?FAPEG) (number grant 2017/10267000531). Foundation of Research Support of the State of Rio Grande do Sul (Funda??o de Amparo ? Pesquisa do Estado do Rio Grande do Sul?FAPERGS) (grant number 17/2551-0000521-0). Foundation to Support Teaching, Research and Assistance at Hospital das Cl?nicas, Faculty of Medicine of Ribeir?o Preto (Funda??o de Apoio ao Ensino, Pesquisa e Assist?ncia do Hospital das Cl?nicas da Faculdade de Medicina de Ribeir?o Preto) and S?o Paulo State Department of Health (Secretaria de Sa?de do Estado de S?o Paulo). Support Foundation of Pernambuco Science and Technology (Funda??o de Amparo ? Ci?ncia e Tecnologia de Pernambuco?FACEPE) (grant numbers APQ-0172-4.01/16; APQ-0192-4.01/17; APQ-0793-4.01/17). 2021-05-24T14:49:35Z 2021-05-24T14:49:35Z 2021 Artigo ALECRIM, Maria das Gra?as Costa et al. Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy. Viruses, v. 13, n. 4, p. 1. 13, Apr. 2021. 1999-4915 http://patua.iec.gov.br//handle/iec/4310 10.3390/v13040687 eng Acesso Aberto application/pdf MDPI |
| institution |
Instituto Evandro Chagas (IEC) |
| collection |
PATUA |
| language |
eng |
| topic |
Zika virus / patogenicidade Infec??o por Zika virus / gen?tica Microcefalia Gestantes Exantema Metan?lise em Rede Estudos de Coortes |
| spellingShingle |
Zika virus / patogenicidade Infec??o por Zika virus / gen?tica Microcefalia Gestantes Exantema Metan?lise em Rede Estudos de Coortes Alecrim, Maria das Gra?as Costa Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
| topic_facet |
Zika virus / patogenicidade Infec??o por Zika virus / gen?tica Microcefalia Gestantes Exantema Metan?lise em Rede Estudos de Coortes |
| description |
Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions. |
| format |
Artigo |
| author |
Alecrim, Maria das Gra?as Costa |
| author2 |
Amorim, Melania Maria Ramos de Ara?jo, Thalia Velho Barreto de Brasil, Patr?cia Brickley, Elizabeth B Castilho, Marcia da Costa Coelho, Bernadete Perez Cunha, Ant?nio Jos? Ledo Alves da Duarte, Geraldo Estofolete, C?ssia Fernanda Gurgel, Ricardo Queiroz Herrero-Silva, Juliana Hofer, Cristina Barroso Lopes, Aline Siqueira Alves Martelli, Celina Maria Turchi Melo, Adriana Suely de Oliveira Miranda Filho, Dem?crito de Barros Montarroyos, Ulisses Ramos Moreira, Maria Elisabeth Mussi-Pinhata, Marisa Marcia Oliveira, Consuelo Silva de Passos, Saulo Duarte Prata-Barbosa, Arnaldo Santos, Darci Neves dos Schuler-Faccini, Lav?nia Silva, Ant?nio Augusto Moura da Siqueira, Isadora Cristina de Sousa, Patr?cia da Silva Turchi, Mar?lia Dalva Ximenes, Ricardo Arraes de Alencar Zara, Ana Laura de Sene Am?ncio |
| author2Str |
Amorim, Melania Maria Ramos de Ara?jo, Thalia Velho Barreto de Brasil, Patr?cia Brickley, Elizabeth B Castilho, Marcia da Costa Coelho, Bernadete Perez Cunha, Ant?nio Jos? Ledo Alves da Duarte, Geraldo Estofolete, C?ssia Fernanda Gurgel, Ricardo Queiroz Herrero-Silva, Juliana Hofer, Cristina Barroso Lopes, Aline Siqueira Alves Martelli, Celina Maria Turchi Melo, Adriana Suely de Oliveira Miranda Filho, Dem?crito de Barros Montarroyos, Ulisses Ramos Moreira, Maria Elisabeth Mussi-Pinhata, Marisa Marcia Oliveira, Consuelo Silva de Passos, Saulo Duarte Prata-Barbosa, Arnaldo Santos, Darci Neves dos Schuler-Faccini, Lav?nia Silva, Ant?nio Augusto Moura da Siqueira, Isadora Cristina de Sousa, Patr?cia da Silva Turchi, Mar?lia Dalva Ximenes, Ricardo Arraes de Alencar Zara, Ana Laura de Sene Am?ncio |
| title |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
| title_short |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
| title_full |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
| title_fullStr |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
| title_full_unstemmed |
Zika Brazilian Cohorts (ZBC) Consortium: protocol for an individual participant data meta-analysis of congenital Zika syndrome after maternal exposure during pregnancy |
| title_sort |
zika brazilian cohorts (zbc) consortium: protocol for an individual participant data meta-analysis of congenital zika syndrome after maternal exposure during pregnancy |
| publisher |
MDPI |
| publishDate |
2021 |
| url |
http://patua.iec.gov.br//handle/iec/4310 |
| _version_ |
1717584485077221376 |
| score |
11.674752 |