Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states

Carvalho-Paulo, Dario; Torres Neto, Jo?o Bento; Santos Filho, Carlos; Oliveira, Thais Cristina Galdino de; Sousa, Aline Amaral; Reis, Renata Rodrigues dos; Santos, Zaire Alves dos; Lima, Camila Mendes de; Oliveira, Marcus Augusto de; Said, Nivin Mazen; Freitas, Sinara Franco; Sosthenes, Marcia Consentino Kronka; Gomes, Giovanni Freitas; Henrique, Ediely Pereira; Pereira, Patrick Douglas C?rrea; Siqueira, Lucas Silva de; Melo, Mauro Andr? Damasceno de; Diniz, Cristovam Guerreiro; Magalh?es, Nara Gyzely de Morais; Diniz, Jos? Ant?nio Pican?o; Vasconcelos, Pedro Fernando da Costa; Diniz, Daniel Guerreiro; Anthony, Daniel Clive; Sherry, David Francis; Brites, Dora; Diniz, Cristovam Wanderley Pican?o

Artigo

Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states

Microglial immunosurveillance of the brain parenchyma to detect local perturbations in homeostasis, in all species, results in the adoption of a spectrum of morphological changes that reflect functional adaptations. Here, we review the contribution of these changes in microglia morphology in distant...

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Autor principal:	Carvalho-Paulo, Dario
Outros Autores:	Torres Neto, Jo?o Bento, Santos Filho, Carlos, Oliveira, Thais Cristina Galdino de, Sousa, Aline Amaral, Reis, Renata Rodrigues dos, Santos, Zaire Alves dos, Lima, Camila Mendes de, Oliveira, Marcus Augusto de, Said, Nivin Mazen, Freitas, Sinara Franco, Sosthenes, Marcia Consentino Kronka, Gomes, Giovanni Freitas, Henrique, Ediely Pereira, Pereira, Patrick Douglas C?rrea, Siqueira, Lucas Silva de, Melo, Mauro Andr? Damasceno de, Diniz, Cristovam Guerreiro, Magalh?es, Nara Gyzely de Morais, Diniz, Jos? Ant?nio Pican?o, Vasconcelos, Pedro Fernando da Costa, Diniz, Daniel Guerreiro, Anthony, Daniel Clive, Sherry, David Francis, Brites, Dora, Diniz, Cristovam Wanderley Pican?o
Grau:	Artigo
Idioma:	eng
Publicado em:	Frontiers Media 2021
Assuntos:	Microglia / citologia Microglia / virologia Testes Neuropsicol?gicos C?rebro / citologia Homeostase Sistema Nervoso Central
Acesso em linha:	http://patua.iec.gov.br//handle/iec/4341

id	ir-iec-4341
recordtype	dspace
spelling	ir-iec-43412021-07-12T13:50:49Z Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states Carvalho-Paulo, Dario Torres Neto, Jo?o Bento Santos Filho, Carlos Oliveira, Thais Cristina Galdino de Sousa, Aline Amaral Reis, Renata Rodrigues dos Santos, Zaire Alves dos Lima, Camila Mendes de Oliveira, Marcus Augusto de Said, Nivin Mazen Freitas, Sinara Franco Sosthenes, Marcia Consentino Kronka Gomes, Giovanni Freitas Henrique, Ediely Pereira Pereira, Patrick Douglas C?rrea Siqueira, Lucas Silva de Melo, Mauro Andr? Damasceno de Diniz, Cristovam Guerreiro Magalh?es, Nara Gyzely de Morais Diniz, Jos? Ant?nio Pican?o Vasconcelos, Pedro Fernando da Costa Diniz, Daniel Guerreiro Anthony, Daniel Clive Sherry, David Francis Brites, Dora Diniz, Cristovam Wanderley Pican?o Microglia / citologia Microglia / virologia Testes Neuropsicol?gicos C?rebro / citologia Homeostase Sistema Nervoso Central Microglial immunosurveillance of the brain parenchyma to detect local perturbations in homeostasis, in all species, results in the adoption of a spectrum of morphological changes that reflect functional adaptations. Here, we review the contribution of these changes in microglia morphology in distantly related species, in homeostatic and non-homeostatic conditions, with three principal goals (1): to review the phylogenetic influences on the morphological diversity of microglia during homeostasis (2); to explore the impact of homeostatic perturbations (Dengue virus challenge) in distantly related species (Mus musculus and Callithrix penicillata) as a proxy for the differential immune response in small and large brains; and (3) to examine the influences of environmental enrichment and aging on the plasticity of the microglial morphological response following an immunological challenge (neurotropic arbovirus infection). Our findings reveal that the differences in microglia morphology across distantly related species under homeostatic condition cannot be attributed to the phylogenetic origin of the species. However, large and small brains, under similar non-homeostatic conditions, display differential microglial morphological responses, and we argue that age and environment interact to affect the microglia morphology after an immunological challenge; in particular, mice living in an enriched environment exhibit a more efficient immune response to the virus resulting in earlier removal of the virus and earlier return to the homeostatic morphological phenotype of microglia than it is observed in sedentary mice. Fundac??o de Amparo ? Pesquisa do Para? ? FADESP/Pro?-Reitoria de Pesquisa e Po?s-Graduac??o da Universidade Federal do Para? ? PROPESP Edital 2020-PIAPA; Coordenac??o de Aperfeic?oamento de Pessoal de N?vel Superior ? ? CAPES ? Pro?-Amazo?nia, Grant No. 3311/2013; Programa Ciencias do Mar II; The Canadian Bureau for ? International Education (CBIE); Brazilian Research Council ? CNPq Grant No. 307749/2004-5 and 471077/2007-0; Fundac??o Amazo?nia de Amparo a Estudos e Pesquisas do Para? ? FAPESPA, ICAAF No. 039/2017; Fundac?o? para a Ciencia e a Tecnologia (PTDC/MED-NEU/31395/2017, ? LISBOA-01-0145-FEDER-031395 and UID/DTP/04138/2018- 2021), as well as by Santa Casa da Miserico?rdia (ALS Research Grant). Brazilian National Research Council - CNPq grants No 573739/2008-0, 457664/2013-4 and 303999/2016-0. 2021-07-12T13:19:56Z 2021-07-12T13:19:56Z 2021 Artigo CARVALHO-PAULO, Dario et al. Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states. Frontiers in Immunology, v. 12, n. 683026, p. 1-19, June 2021. 1664-3224 http://patua.iec.gov.br//handle/iec/4341 10.3389/fimmu.2021.683026 eng Acesso Aberto application/pdf Frontiers Media
institution	Instituto Evandro Chagas (IEC)
collection	PATUA
language	eng
topic	Microglia / citologia Microglia / virologia Testes Neuropsicol?gicos C?rebro / citologia Homeostase Sistema Nervoso Central
spellingShingle	Microglia / citologia Microglia / virologia Testes Neuropsicol?gicos C?rebro / citologia Homeostase Sistema Nervoso Central Carvalho-Paulo, Dario Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states
topic_facet	Microglia / citologia Microglia / virologia Testes Neuropsicol?gicos C?rebro / citologia Homeostase Sistema Nervoso Central
description	Microglial immunosurveillance of the brain parenchyma to detect local perturbations in homeostasis, in all species, results in the adoption of a spectrum of morphological changes that reflect functional adaptations. Here, we review the contribution of these changes in microglia morphology in distantly related species, in homeostatic and non-homeostatic conditions, with three principal goals (1): to review the phylogenetic influences on the morphological diversity of microglia during homeostasis (2); to explore the impact of homeostatic perturbations (Dengue virus challenge) in distantly related species (Mus musculus and Callithrix penicillata) as a proxy for the differential immune response in small and large brains; and (3) to examine the influences of environmental enrichment and aging on the plasticity of the microglial morphological response following an immunological challenge (neurotropic arbovirus infection). Our findings reveal that the differences in microglia morphology across distantly related species under homeostatic condition cannot be attributed to the phylogenetic origin of the species. However, large and small brains, under similar non-homeostatic conditions, display differential microglial morphological responses, and we argue that age and environment interact to affect the microglia morphology after an immunological challenge; in particular, mice living in an enriched environment exhibit a more efficient immune response to the virus resulting in earlier removal of the virus and earlier return to the homeostatic morphological phenotype of microglia than it is observed in sedentary mice.
format	Artigo
author	Carvalho-Paulo, Dario
author2	Torres Neto, Jo?o Bento Santos Filho, Carlos Oliveira, Thais Cristina Galdino de Sousa, Aline Amaral Reis, Renata Rodrigues dos Santos, Zaire Alves dos Lima, Camila Mendes de Oliveira, Marcus Augusto de Said, Nivin Mazen Freitas, Sinara Franco Sosthenes, Marcia Consentino Kronka Gomes, Giovanni Freitas Henrique, Ediely Pereira Pereira, Patrick Douglas C?rrea Siqueira, Lucas Silva de Melo, Mauro Andr? Damasceno de Diniz, Cristovam Guerreiro Magalh?es, Nara Gyzely de Morais Diniz, Jos? Ant?nio Pican?o Vasconcelos, Pedro Fernando da Costa Diniz, Daniel Guerreiro Anthony, Daniel Clive Sherry, David Francis Brites, Dora Diniz, Cristovam Wanderley Pican?o
author2Str	Torres Neto, Jo?o Bento Santos Filho, Carlos Oliveira, Thais Cristina Galdino de Sousa, Aline Amaral Reis, Renata Rodrigues dos Santos, Zaire Alves dos Lima, Camila Mendes de Oliveira, Marcus Augusto de Said, Nivin Mazen Freitas, Sinara Franco Sosthenes, Marcia Consentino Kronka Gomes, Giovanni Freitas Henrique, Ediely Pereira Pereira, Patrick Douglas C?rrea Siqueira, Lucas Silva de Melo, Mauro Andr? Damasceno de Diniz, Cristovam Guerreiro Magalh?es, Nara Gyzely de Morais Diniz, Jos? Ant?nio Pican?o Vasconcelos, Pedro Fernando da Costa Diniz, Daniel Guerreiro Anthony, Daniel Clive Sherry, David Francis Brites, Dora Diniz, Cristovam Wanderley Pican?o
title	Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states
title_short	Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states
title_full	Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states
title_fullStr	Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states
title_full_unstemmed	Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states
title_sort	microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states
publisher	Frontiers Media
publishDate	2021
url	http://patua.iec.gov.br//handle/iec/4341
_version_	1717584431659614208
score	11.687526

Microglial morphology across distantly related species: phylogenetic, environmental and age influences on microglia reactivity and surveillance states

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